SkyScan 1076 In Vivo Micro-Computed Tomography System

SkyScan 1076 体内微型计算机断层扫描系统

• 批准号: 7794594
• 负责人: Timothy M Ryan
• 金额: $ 38.75万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-10 至 2011-07-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794594
• 关键词: Acute; Address; Adult; Animals; Antibodies; Arthritis; Asthma; Atherosclerosis; Biological Sciences; Biomedical Research; Brain; Collagen; Craniosynostosis; Data; Data Collection; Development; Diagnosis; Disease; Epilepsy; Extrinsic asthma; Funding; Future; Gene Expression; Health; Human; Hydrocephalus; Image; Individual; Life; Malignant Neoplasms; Mediating; Metabolic Diseases; Microcomputers; Modeling; Molecular; Mus; Musculoskeletal; Neurons; Obesity; Pattern Formation; Phase; Protocols documentation; Public Health; Rattus; Repression; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resolution; Scanning; Skiing; Structure; Students; System; Techniques; Time; Tissues; United States National Institutes of Health; Universities; Work; X-Ray Computed Tomography; college; cranium; imaging modality; improved; in vivo; innovation; instrument; mouse model; neuronal patterning; public health relevance; receptor; social; tomography

DESCRIPTION (provided by applicant): This proposal seeks funds to purchase a Sky Scan 1076 in vivo microcomputer tomography (microCT) scanner to be installed in the Penn State University (PSU) Social and Life Sciences Imaging Center (SLIC) at the University Park, PA, campus. This system will help several currently- funded NIH investigators as well as other researchers address challenging biomedical questions by allowing non-invasive assessment of anatomical structures, disease states, and treatments. The strength of the Sky Scan 1076 is its ability to acquire high resolution images (down to 9 mm) of live animals ranging in size from mouse to adult rat. This instrument will directly benefit the research of 14 different researchers spanning 8 departments and 5 colleges at PSU. Of these, 5 have current NIH funded projects that would make immediate use of the instrument and 9 others could use the system for pilot work directed toward future proposals. The data collection and experimental protocols of the funded NIH projects would benefit significantly from the acquisition and use of in vivo microCT, allowing more efficient techniques to be developed and more robust data to be collected. The funded NIH projects include: 1) Phenogenetics of Skull and Brain Integration in Craniosynostosis (R01DE018500-02); 2) Molecular Mechanisms of Allergic Asthma Development (R01AI073955-01A2, R01AI065566-04, R01AI051626-07); 3) Ah Receptor-Mediated Repression of Acute Phase Gene Expression in a Collagen Antibody Induced Arthritis Mouse Model (R01ES04869-20); 4) Dynamics and Control of Neuronal Pattern Formation (R01MH50006-15, K02MH01493-10); and 5) CRCNS: Mechanisms of Wave Propagation in Neuronal Tissue (R01MH079502-01). Although high-resolution CT is available elsewhere on campus, no other system at PSU is capable of scanning live animals. In vivo microCT scanning provides many benefits over traditional high-resolution scanning for biomedical research. Principal among these benefits is the ability to track structures, diseases, or treatments longitudinally in the same individuals across extended periods of time. The microCT scanner will be a valuable addition to the imaging infrastructure at PSU that will allow for expanded biomedical research using both mouse and rat models. The integration of multiple imaging modalities offers significant opportunities for innovative and transformational research of relevance to many human health issues such as cancer, musculoskeletal, and metabolic diseases. In addition, together with the other imaging capabilities on campus, this instrument will allow for significant training and research opportunities for students. PUBLIC HEALTH RELEVANCE: This project proposes to install a high-resolution live animal imaging system at Penn State University to support current and future biomedical research projects on topics of significant importance to public health including asthma, arthritis, craniosynostosis, epilepsy, hydrocephalus, atherosclerosis, and obesity. The new imaging system will allow more accurate and powerful analyses to be conducted which will help improve diagnosis and treatment of these and other important health issues.

描述（由申请人提供）：本提案寻求资金购买Sky Scan 1076体内微型计算机断层扫描（microCT）扫描仪，安装在宾夕法尼亚州立大学（PSU）位于宾夕法尼亚州大学公园的社会和生命科学成像中心（SLIC）。该系统将帮助一些目前资助的NIH研究人员以及其他研究人员通过允许对解剖结构、疾病状态和治疗进行非侵入性评估来解决具有挑战性的生物医学问题。Sky Scan 1076的优势在于它能够获得从小鼠到成年大鼠大小的活体动物的高分辨率图像（低至9毫米）。该仪器将直接惠及PSU 8个系和5个学院的14名不同研究人员的研究。其中，5家目前拥有NIH资助的项目，可以立即使用该仪器，另外9家可以将该系统用于针对未来提案的试点工作。美国国立卫生研究院资助项目的数据收集和实验方案将从体内微ct的获取和使用中受益匪浅，从而开发出更有效的技术，收集到更可靠的数据。资助的NIH项目包括：1)颅缝闭合颅骨和脑整合的表型遗传学（R01DE018500-02）；2)过敏性哮喘发生的分子机制（R01AI073955-01A2, R01AI065566-04, R01AI051626-07）；3) Ah受体介导的胶原抗体诱导关节炎小鼠模型急性期基因表达抑制（R01ES04869-20）；4)神经元模式形成的动力学与控制（R01MH50006-15, K02MH01493-10）；5) CRCNS：神经组织中的波传播机制（R01MH079502-01）。虽然高分辨率的CT在校园的其他地方也可用，但在PSU没有其他系统能够扫描活体动物。活体微ct扫描为生物医学研究提供了比传统高分辨率扫描更多的好处。这些好处中最主要的是能够在长时间内对同一个体的结构、疾病或治疗进行纵向跟踪。微型ct扫描仪将是PSU成像基础设施的一个有价值的补充，它将允许使用小鼠和大鼠模型扩展生物医学研究。多种成像模式的整合为与许多人类健康问题（如癌症、肌肉骨骼和代谢疾病）相关的创新和变革性研究提供了重要机会。此外，与校园内的其他成像功能一起，该仪器将为学生提供重要的培训和研究机会。