3T MR Scanner for Translational Research using MRI and MRSI

使用 MRI 和 MRSI 进行转化研究的 3T MR 扫描仪

• 批准号: 7840027
• 负责人: SARAH J. NELSON
• 金额: $ 229.95万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-03 至 2012-06-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7840027
• 关键词: Adoption; Aging; Aging-Related Process; Anatomy; Applications Grants; Area; Automobile Driving; Award; Biological Markers; Biological Models; Clinical Research; Computer software; Data; Development; Disease; Disease Progression; Economics; Employment; Ensure; Environmental Impact; Equipment; Evaluation; FDA approved; Faculty; Functional Imaging; Funding; Grant; Human; Image; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Measurement; Metabolic; Methodology; Molecular; Musculoskeletal; Nuclear; Occupations; Patients; Performance; Physiological; Postdoctoral Fellow; Pre-Clinical Model; Procedures; Process; Protons; Quality of Care; Recovery; Research; Research Personnel; Research Project Grants; Research Proposals; Resolution; San Francisco; Sensitivity and Specificity; Spectrum Analysis; System; Techniques; Technology; Translating; Translational Research; United States; United States National Institutes of Health; Universities; career development; clinically relevant; design; human disease; improved; instrumentation; nervous system disorder; new technology; novel; novel strategies; novel therapeutics; pre-clinical; programs; public health relevance; research study; response; spectroscopic imaging; systems research; technique development; technology development

DESCRIPTION (provided by applicant): The objective of this proposal is to provide support to purchase an advanced 3T whole body MR scanner that includes new high-performance instrumentation for dynamic nuclear polarization (DNP) and specialized components for acquiring cutting edge anatomic, physiological and metabolic imaging data. This is critical for supporting a large number of NIH funded research programs that are developing and translating new imaging strategies with increased sensitivity and specificity for the evaluation of novel therapeutics in pre-clinical and patient studies. The proposed scanner will replace and significantly enhance the capabilities of an existing research system that is unable to keep up with the hardware and software requirements of the new techniques that are being developed. The focus for the research that will use the new scanner is the development of high resolution Magnetic Resonance Imaging (MRI) and spectroscopy (MRS) of patients for translational, clinical- research applications. This is important for the implementation and evaluation of new methodologies, maintaining current funded projects and expanding the large number of highly successful MR research projects at UCSF. The proposed 3T scanner and accompanying hardware will support 21 active and 8 pending NIH research grants and technology development projects from 28 faculty and their collaborators. The specific aims for the research that will be performed on the system are as follows: 1) To provide a platform for translating new MR techniques into clinically relevant, FDA approved procedures that support studies in pre-clinical model systems and in patients. 2) To validate MR parameters that can be used as biomarkers for characterizing disease and assessing response to therapy. 3) To support research projects requiring serial MRI and H-1 MRSI measurements from patients being treated with novel therapies. 4) To investigate the applications of hyperpolarized C-13, P-31 and other multinuclear MRS techniques that use echo planar spatial encoding, parallel imaging strategies and novel rf coil designs. Major focus areas include the development of techniques for studying normal processes such as aging and development, and for translational research associated with cancer, musculoskeletal and a wide range of neurological diseases. PUBLIC HEALTH RELEVANCE: The Center for Molecular and Functional Imaging at UCSF supports a large number of comprehensive and multi-faceted Magnetic Resonance research projects that are applying novel technology to the characterization of human diseases and the normal processes of aging and development. In order to enhance these translational research studies, it is critical that the equipment is kept at the cutting edge of available technology. This proposal is requesting funds to provide a new GE 750MR scanner with a DNP polarizer and advanced capabilities for performing high resolution anatomic, physiological and functional imaging in conjunction with proton MR spectroscopic imaging and MR metabolic imaging with hyperpolarized C-13 agents. These capabilities will allow researchers to obtain significant improvements in sensitivity and specificity for characterizing normal human processes and for evaluating abnormalities associated with disease progression and response to therapy. At UCSF, award of this grant application would ensure the continued employment in research groups, career development of research investigators and new job opportunities by augmenting 21 current and 8 pending grants from 28 Principle Investigators. The selection of the GE Discovery MR750 system in support of the University of San Francisco's research proposal will have a positive impact on the United States economic recovery through: maintaining employment in the United States, driving adoption of new technology to improve quality of care and creation of new jobs; and positive environmental impacts.

描述（由申请人提供）：本提案的目的是为购买先进的3T全身MR扫描仪提供支持，该扫描仪包括用于动态核极化（DNP）的新型高性能仪器和用于获取尖端解剖，生理和代谢成像数据的专用组件。这对于支持大量NIH资助的研究项目是至关重要的，这些项目正在开发和翻译新的成像策略，这些策略具有更高的敏感性和特异性，用于临床前和患者研究中对新疗法的评估。拟议的扫描仪将取代并大大提高现有研究系统的能力，该系统无法跟上正在开发的新技术的硬件和软件要求。研究的重点是将使用新的扫描仪的高分辨率磁共振成像（MRI）和光谱（MRS）的患者转化，临床研究应用的发展。这对于新方法的实施和评估，维持当前资助的项目以及扩大加州大学旧金山分校大量非常成功的MR研究项目非常重要。拟议的3T扫描仪和配套硬件将支持来自28名教师及其合作者的21个活跃和8个未决的NIH研究资助和技术开发项目。将在该系统上进行的研究的具体目标如下：1)提供一个平台，将新的MR技术转化为临床相关的，FDA批准的程序，支持临床前模型系统和患者的研究。2)验证可作为表征疾病和评估治疗反应的生物标志物的MR参数。3)支持需要对接受新疗法治疗的患者进行连续MRI和H-1 MRI测量的研究项目。4)研究超极化C-13、P-31和其他采用回波平面空间编码、并行成像策略和新型射频线圈设计的多核磁共振成像技术的应用。主要重点领域包括研究正常过程的技术发展，如衰老和发育，以及与癌症、肌肉骨骼和广泛的神经系统疾病相关的转化研究。