Baltimore CASCADE Study Site (BaCSS Project)

巴尔的摩梯级研究站点(Bacss项目) 项目总结 艾滋病毒携带者(WLWH)由于免疫不全，患宫颈癌的风险更高 宫颈癌危险因素的重建性和高发率。在非裔美国人中风险更大 (Aa)西巴尔的摩等经济和社会不利地区的WLWH，因为交叉路口 与种族、性别、健康的社会决定因素(SDOH)以及包括药物滥用在内的艾滋病毒共病有关。 尽管基于人群的宫颈癌筛查在美国得到了广泛的应用，但居住在 贫困地区的筛查接受率较低。对最近开发和开发的 迫切需要用于在预定用途环境中预防宫颈癌的新兴方法和技术 以满足这一人群的宫颈癌预防需求。 在Bacss项目中，我们利用了加州大学的临床和人口科学资源 马里兰州医学院(UMSOM)建立了一个级联网络的临床研究网站。该网站将 将AA-WLWH纳入循证干预的实施科学研究和临床试验 宫颈癌的预防和早期诊断。该项目提供业务领导和多面性 在级联网络中为这些研究提供基础设施，并支持概念和 克服障碍的经临床验证的干预措施的有效性的实用临床试验方案 并减少世界卫生组织在预防宫颈癌方面的失败。

Baltimore CASCADE Study Site (BaCSS Project) Project summary Women living with HIV (WLWH) have a higher risk of cervical cancer because of incomplete immune reconstitution and high prevalence of risk factors for cervical cancer. The risk is greater among African American (AA) WLWH in economically and socially disadvantaged areas such as West Baltimore because of intersection with race, gender, social determinants of health (SDOH), and HIV co-morbidities including substance abuse. Despite the widespread availability of population-based cervical cancer screening in the US, AA-WLWH living in disadvantaged areas have lower rates of screening uptake. Strategic evaluations of recently developed and emerging methods and technologies for cervical cancer prevention in intended use settings are urgently needed to address the cervical cancer prevention needs of this population. In the BaCSS project, we engage the clinical and population science resources of the University of Maryland School of Medicine (UMSOM) to establish a clinical study site for the CASCADE network. The site will enroll AA-WLWH into implementation science studies and clinical trials of evidence-based interventions for the prevention and early diagnosis of cervical cancer. The project provides operational leadership and pluripotent infrastructure for these studies in the CASCADE network and supports the development of concepts and protocols for pragmatic clinical trials of the effectiveness of clinically proven interventions to overcome barriers and reduce failures in cervical cancer prevention in WLWH.