Baltimore CASCADE Study Site (BaCSS Project)

巴尔的摩 CASCADE 研究基地（BaCSS 项目）

• 批准号: 10757186
• 负责人: Clement Adebayo Adebamowo
• 金额: $ 30.9万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10757186
• 关键词: Address; African American; Age; Age of Onset; Alcohol abuse; Area; Artificial Intelligence; Baltimore; Caring; Cervical; Cervical Cancer Screening; Characteristics; Cities; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Network; Clinical effectiveness; Collaborations; Colposcopy; Communicable Diseases; Communities; Community Outreach; Comprehensive Cancer Center; County; Cytopathology; Data; Data Science; Development; Disadvantaged; Disease; Early Diagnosis; Emerging Technologies; Enrollment; Ethnic Origin; Evaluation; Evidence based intervention; Excision; Failure; Gender; Gynecologic Oncology; HIV; Health; Health Services Accessibility; Heterogeneity; High Prevalence; Home; Housing; Human Papillomavirus; Human Resources; Incidence; Informatics; Infrastructure; Intervention; Laboratories; Leadership; Link; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Maryland; Mental Health; Methods; Neighborhoods; Outcome; Patients; Population; Population Sciences; Poverty; Pragmatic clinical trial; Prevalence; Prevention; Protocols documentation; Race; Recurrent disease; Research; Resources; Risk; Risk Factors; Sampling; Services; Site; Substance abuse problem; Technology; Translational Research; Transportation; Universities; University resources; Viral Load result; Visualization; Woman; cervical cancer prevention; cervicovaginal; chronic infection; clinically significant; community engagement; comorbidity; computerized; data management; economic disparity; effectiveness clinical trial; effectiveness evaluation; ethnic disparity; health care availability; health care service; health illiteracy; high risk; immune reconstitution; implementation science; implementation strategy; improved; inner city; insight; medical schools; molecular diagnostics; mortality; new technology; novel; oncology service; patient navigation; peer support; population based; pragmatic implementation; premalignant; preventive intervention; programs; protocol development; racial disparity; recruit; screening; screening guidelines; sex; social disparities; social health determinants; uptake

Baltimore CASCADE Study Site (BaCSS Project) Project summary Women living with HIV (WLWH) have a higher risk of cervical cancer because of incomplete immune reconstitution and high prevalence of risk factors for cervical cancer. The risk is greater among African American (AA) WLWH in economically and socially disadvantaged areas such as West Baltimore because of intersection with race, gender, social determinants of health (SDOH), and HIV co-morbidities including substance abuse. Despite the widespread availability of population-based cervical cancer screening in the US, AA-WLWH living in disadvantaged areas have lower rates of screening uptake. Strategic evaluations of recently developed and emerging methods and technologies for cervical cancer prevention in intended use settings are urgently needed to address the cervical cancer prevention needs of this population. In the BaCSS project, we engage the clinical and population science resources of the University of Maryland School of Medicine (UMSOM) to establish a clinical study site for the CASCADE network. The site will enroll AA-WLWH into implementation science studies and clinical trials of evidence-based interventions for the prevention and early diagnosis of cervical cancer. The project provides operational leadership and pluripotent infrastructure for these studies in the CASCADE network and supports the development of concepts and protocols for pragmatic clinical trials of the effectiveness of clinically proven interventions to overcome barriers and reduce failures in cervical cancer prevention in WLWH.

巴尔的摩CASCADE研究中心（BaCSS项目） 项目摘要 感染艾滋病毒的妇女（WLWH）由于免疫不完全，患宫颈癌的风险较高。 子宫颈癌的发病率高，是导致宫颈癌的主要原因。非裔美国人的风险更大 (AA)WLWH在经济和社会上处于不利地位的地区，如西巴尔的摩，因为交叉口 种族、性别、健康的社会决定因素（SDOH）和艾滋病毒合并症，包括药物滥用。 尽管在美国广泛开展了基于人群的宫颈癌筛查，但生活在美国的AA-WLWH患者仍然认为， 贫困地区的筛查率较低。对最近制定的战略进行评价， 迫切需要在预期使用环境中预防宫颈癌的新兴方法和技术 以满足这一人群的宫颈癌预防需求。 在BaCSS项目中，我们利用了纽约大学的临床和人口科学资源， 马里兰州医学院（UMSOM）为CASCADE网络建立一个临床研究中心。该网站将 将AA-WLWH纳入循证干预措施的实施科学研究和临床试验， 预防和早期诊断宫颈癌。该项目提供业务领导和多能 CASCADE网络中这些研究的基础设施，并支持概念的发展， 临床验证干预措施有效性的实用临床试验协议，以克服障碍 并减少WLWH宫颈癌预防的失败。