Nfib regulates glial differentiation during development and disease via repression of the key epigenetic protein, Ezh2

Nfib 通过抑制关键表观遗传蛋白 Ezh2 来调节发育和疾病过程中的神经胶质细胞分化

• 批准号: nhmrc : 1022308
• 负责人: A/Pr Michael Piper
• 金额: $ 38.2万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nfib-regulates-glial-protein-ezh2/110180
• 关键词: Nfib; regulates; glial; differentiation; during

Glial development is critical during development, and unrestrained proliferation of glial stem cells in the adult can lead to deadly brain cancers such as glioma. At present there is no cure for glioma and current treatments do not significantly delay tumour progression. Nfib is a transcription factor that may prevent tumour growth through cellular differentiation. We will investigate the role of Nfib during development and in the pathogenesis of glioma and its potential as a therapeutic target.

神经胶质细胞的发育在发育过程中至关重要，成人神经胶质干细胞的不受限制的增殖可能导致致命的脑癌，例如神经胶质瘤。 At present there is no cure for glioma and current treatments do not significantly delay tumour progression. Nfib 是一种转录因子，可以通过细胞分化阻止肿瘤生长。我们将研究 Nfib 在神经胶质瘤的发育和发病机制中的作用及其作为治疗靶点的潜力。