Nfi genes regulate the switch between neurogenesis and gliogenesis during cortical development

Nfi 基因调节皮质发育过程中神经发生和胶质细胞发生之间的转换

• 批准号: nhmrc : 569502
• 负责人: A/Pr Michael Piper
• 金额: $ 25.84万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nfi-genes-regulate-cortical-development/116108
• 关键词: Nfi; genes; regulate; switch; between

Cells within the brain fall into two categories; neurons or glia. Importantly, both derive from a common progenitor population, the radial glia, during development. Early in development radial glia produce neurons, while later they generate glia. The genes which control the switch from neuron production to glia production remain poorly defined. I propose to investigate how this switch is controlled in radial glia, focussing on a family of proteins known to regulate gene transcription.

大脑内的细胞分为两类：神经元或神经胶质细胞。重要的是，在发育过程中，两者都来自共同的祖细胞群体--放射状胶质细胞。在发育的早期，放射状胶质细胞产生神经元，而后来它们产生胶质细胞。控制从神经元产生到神经胶质产生的转换的基因仍然没有明确的定义。我建议研究这种开关是如何在放射状胶质细胞中被控制的，重点放在一个已知的调节基因转录的蛋白质家族上。