Behavioral Core

核心B：行为核心：(韦尔塔导演) 该核心将通过提供集中的资源来增强计划中的各个项目 在小鼠身上进行行为分析，以检验主要证候的主要假说 神经精神性红斑狼疮(NPSLE)是由结合 N-甲基-D-天冬氨酸受体(NMDAR)的NR2A和NR2B亚基。具体地说， 项目1、项目2和项目4中描述的研究关键取决于仔细 检查小鼠的行为表现。老鼠将受到全面的 一系列的行为测试，旨在测量他们的神经反射，感觉运动技能， 认知能力、情绪过程、学习和记忆；然而，我们将重点放在 抗NMDAR抗体对特定认知任务的影响 特定的NMDAR丰富的大脑区域。行为核心将确保所有测试都将是 在类似的环境条件下执行，并遵循相同的议定书指南。 这将允许直接比较不同鼠标组的测试结果 不同时间的自身抗体。另一个明显的优势将是自动化的可用性 跟踪动物和软件驱动的协议，从而最大限度地减少人为错误和主观 得分。最后，数据将以集中方式存储，所有数据都可以轻松访问 该计划中的调查人员。

Core B: Behavioral Core: (Huerta Director) This Core will enhance the individual projects in the Program by providing centralized resources for performing behavioral analysis in mice to test the main hypothesis that key syndromes of neuropsychiatric lupus erythematosus (NPSLE) are caused by autoantibodies that bind the NR2A and NR2B subunits of the N-methyl-D-aspartate receptor (NMDAR). Specifically, the research described in Project 1, Project 2 and Project 4 depends crucially on careful examination of the behavioral performance of mice. Mice will be subjected to a comprehensive battery of behavioral tests, designed to measure their neurological reflexes, sensorimotor skills, cognitive abilities, emotional processes, learning and memory; however, we will focus on the effects of anti-NMDAR antibodies on specific cognitive tasks that depend on the integrity of a specific NMDAR-rich brain area. The Behavioral Core will ensure that all the tests will be executed under similar environmental conditions and following the same protocol guidelines. This will permit a direct comparison of results across mouse groups tested for different autoantibodies on different times. Another clear advantage will be availability of automated tracking of animals and software-driven protocols, thus minimizing human error and subjective scoring. Finally, the data will be stored in a centralized fashion, with simple access to all investigators in the Program.