INTRANASAL OXYTOCIN CHALLENGE IN BORDERLINE PERSONALITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目前的研究旨在作为一项试点研究，以产生数据，检查催产素管理对患有交界性人格障碍(BPD)的个人的影响。BPD是一种DSM-IV人格障碍，以冲动、愤怒、情感不稳定和身份混淆等慢性普遍症状为特征。我们希望探索是否有初步证据表明催产素对BPD患者的社交和应激相关障碍有调节作用。如果初步数据是有希望的，调查人员计划进行更大规模的研究。 目前的研究将从招募20名患有BPD的成年人和20名正常对照成年人开始。在签署知情同意书后，受试者将接受研究精神病学家的精神病学评估，研究精神病学家将确定初步诊断和资格，这将通过管理DSM-IV轴I障碍的结构化临床面试和DSM-IV人格障碍SIDP-IV的结构化面试来确定。还将进行一系列访谈，以评估包括既往创伤、人际关系风格、压力水平、信任、自尊和冲动等指标在内的指标。基线评估后，受试者将被安排到达临床研究中心，并将接受常规实验室测试。受试者将以双盲方式随机接受第一次挑战时接受催产素或安慰剂的治疗。第二次挑战将安排在第一次挑战之后的一到两周内，每个受试者都将接受另一种情况。挑战任务将包括情绪状态简介、词汇决定任务、囚徒困境游戏任务和特里尔社会压力测试。挑战任务的结果将与实验室样本进行分析和比较。 假设：在健康对照组和BPD组中，假设催产素将导致基于信任的亲社会认知和行为增强，并降低皮质醇对心理社会压力的反应性。预计在催产素挑战下，BPD组在基于信任的亲社会认知和行为方面将显示出比健康对照组更大的好处。相反，我们预测，在安慰剂挑战下，BPD组的亲社会认知和行为比健康对照组更严重。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The current study is intended as a pilot study to generate data that examines the impact of oxytocin administration in individuals with Borderline Personality Disorder (BPD). BPD is a DSM-IV personality disorder characterized by chronic and pervasive symptoms of impulsivity, anger, affective instability and identity confusion. We hope to explore whether there is preliminary evidence of oxytocin modulation of social and stress related disturbances in BPD. If preliminary data are promising, the investigators plan to pursue a larger study. The current study will begin with recruitment of twenty adults with BPD and twenty normal control adults. After signing informed consent, subjects will undergo a psychiatric evaluation by a study psychiatrist who will determine preliminary diagnoses and eligibility, which will be determined by administration of the Structured Clinical Interview for DSM-IV Axis I Disorders and the Structured Interview for DSM-IV Personality Disorders SIDP-IV. A series of interviews will also be conducted to assess measures including past trauma, relationship styles, stress levels, trust, self-esteem and impulsivity among other measures. After the Baseline Evaluation, subjects will be scheduled to arrive at the clinical research center and will receive routine laboratory tests. Subjects will be randomized in a double-blind fashion to receive either oxytocin or placebo on their first challenge. The second challenge will be scheduled within 1 to 2 weeks after the first one, and each subject will receive the alternate condition. Challenge tasks will include the Profile of Mood States, the Lexical Decision Task, The Prisoner's Dilemma Game Task and the Trier Social Stress Test. Results of the challenge tasks and laboratory samples will be analyzed and compared. Hypothesis: It is hypothesized that oxytocin will cause enhanced trust-based prosocial cognitions and behaviors and diminished cortisol reactivity to psychosocial stress in both the healthy controls and the BPD group. It is expected that the BPD group will show greater benefits in trust-based prosocial cognitions and behaviors than the healthy controls under the oxytocin challenge. Conversely, we predict to see greater impairment in prosocial cognitions and behaviors in the BPD group than in the healthy controls under the placebo challenge.