ARTERIAL DYSFUNCTION IN PED PATIENTS WITH IMPAIRED FASTING GLUCOSE

空腹血糖受损的 PED 患者的动脉功能障碍

• 批准号: 7717142
• 负责人: Henry W Rohrs
• 金额: $ 0.33万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717142
• 关键词: Adult; Age-Years; Arteries; Blood Vessels; Body mass index; Cardiovascular Diseases; Cause of Death; Cessation of life; Child; Childhood; Computer Retrieval of Information on Scientific Projects Database; Data; Diabetes Mellitus; Documentation; Epidemic; Functional disorder; Funding; Future; Grant; IFNG gene; Impaired fasting glycaemia; Incidence; Institution; Intervention; Life; Measurement; Morbidity - disease rate; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Patients; Peripheral; Population; Race; Radial; Research; Research Personnel; Resources; Risk; Source; Time; United States National Institutes of Health; arterial stiffness; glucose metabolism; mortality; prevent; radial artery; reactive hyperemia; research study; sex; tonometry; type 2 diabetes in children

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiovascular disease is the leading cause of death worldwide and Type 2 diabetes mellitus T2DM increases the risk of death from cardiovascular disease CVD by 5 to 7 times. The CVD risk in pre-diabetes remains elevated in the large percentage of patients who never go on to develop type 2 diabetes. Recent data with regards to pre-diabetes have been generated from adult research studies, the growing pediatric obesity epidemic and increasing incidence of type 2 diabetes in children necessitates research aimed at identifying children at risk for developing CVD early in life. Recent adult data have demonstrated that the highest CVD risk amongst pre-diabetes subjects may be in those with IFG. We hypothesize that pediatric patients with IFG have more vascular dysfunction than sex-, race-, and body mass index BMI matched patients with normal glucose metabolism NGM. Radial artery tonometry and reactive hyperemia peripheral artery tonometry RH-PAT are two noninvasive surrogate measurements of arterial stiffness and endothelial function that have been used to predict future CVD in adults and have been used to demonstrate abnormalities in other pediatric populations with elevated CVD risk. We will obtain radial tonometry and RH-PAT measurements in patients 10-18 years of age with IFG and in sex-, race-, and BMI-matched controls with NGM. Documentation of increased arterial stiffness and endothelial dysfunction in children with IFG will support aggressive intervention in pediatric populations with IFG to prevent morbidity and mortality associated with CVD.

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