ARTERIAL DYSFUNCTION IN PEDIATRIC PATIENTS WITH IMPAIRED FASTING GLUCOSE

空腹血糖受损的儿科患者的动脉功能障碍

• 批准号: 7950753
• 负责人: Henry W Rohrs
• 金额: $ 0.42万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950753
• 关键词: 18 year old; Adult; Arteries; Blood Vessels; Body mass index; Cardiovascular Diseases; Cause of Death; Cessation of life; Child; Childhood; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Data; Documentation; Epidemic; Functional disorder; Funding; Future; Grant; Impaired fasting glycaemia; Incidence; Institution; Intervention; Life; Measurement; Morbidity - disease rate; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Patients; Peripheral; Population; Prediabetes syndrome; Race; Radial; Research; Research Personnel; Resources; Risk; Source; Time; United States National Institutes of Health; arterial stiffness; cardiovascular disorder risk; glucose metabolism; impaired glucose tolerance; mortality; prevent; radial artery; reactive hyperemia; research study; sex; tonometry; type 2 diabetes in children

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiovascular disease (CVD) is the leading cause of death worldwide and Type 2 diabetes mellitus (T2DM) increases the risk of death from CVD by 5 to 7 times. Pre-diabetes, defined as a state of either impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), is associated with an increased risk of CVD. The CVD risk in pre-diabetes remains elevated even in the large percentage of patients who never go on to develop type 2 diabetes. While recent data have largely been generated from adult research studies, the growing pediatric obesity epidemic and increasing incidence of type 2 diabetes in children necessitates research aimed at identifying children at risk for developing CVD early in life. Recent adult data have demonstrated that the highest CVD risk amongst pre-diabetes subjects may be in those with IFG. We hypothesize that pediatric patients with IFG have more vascular dysfunction than sex-, race-, and body mass index (BMI)-matched patients with normal glucose metabolism (NGM). Radial artery tonometry and reactive hyperemia peripheral artery tonometry (RH-PAT) are two noninvasive surrogate measurements of arterial stiffness and endothelial function that have been used to predict future CVD in adults and have been used to demonstrate abnormalities in other pediatric populations with elevated CVD risk. We will obtain radial tonometry and RH-PAT measurements in patients 10-18 years of age with IFG. Documentation of increased arterial stiffness and endothelial dysfunction in children with IFG will support aggressive intervention in pediatric populations with IFG to prevent morbidity and mortality associated with CVD.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 心血管疾病（CVD）是全球死亡的主要原因，2型糖尿病（T2 DM）使CVD死亡风险增加5至7倍。糖尿病前期，定义为空腹血糖受损（IFG）或糖耐量受损（IGT）的状态，与CVD风险增加相关。即使在绝大多数从未发展为2型糖尿病的患者中，糖尿病前期的CVD风险仍然升高。虽然最近的数据主要来自成人研究，但儿童肥胖症的流行和儿童2型糖尿病发病率的增加需要进行旨在确定儿童在生命早期发生CVD风险的研究。 最近的成人数据表明，糖尿病前期受试者中CVD风险最高的可能是IFG患者。 我们假设IFG患儿比性别、种族和体重指数（BMI）匹配的糖代谢正常（NGM）患者有更多的血管功能障碍。 桡动脉张力测定和反应性充血外周动脉张力测定（RH-PAT）是动脉硬度和内皮功能的两种无创替代测量，已用于预测成人未来的CVD，并已用于证明其他CVD风险升高的儿科人群的异常。 我们将获得10-18岁IFG患者的桡动脉眼压和RH-PAT测量结果。 IFG儿童动脉僵硬度增加和内皮功能障碍的记录将支持IFG儿童人群的积极干预，以预防CVD相关的发病率和死亡率。