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A Patient-Oriented Research Mentoring Program in Tobacco Dependence Research

烟草依赖性研究中以患者为导向的研究指导计划

基本信息

批准号：
10094212
负责人：
Robert A Schnoll
金额：
$ 18.7万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-03-01 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10094212
关键词：
Address Adult Advisory Committees Advocacy Advocate Area Award Behavioral Biological Markers Cancer Center Caring Data Educational process of instructing Educational workshop Effectiveness Electronic Health Record Employment Ensure Evaluation Faculty Fostering Funding Goals Grant Individual Industry Leadership Link Medical Mentors Mentorship Metabolic Clearance Rate Methods Modeling National Institute of Drug Abuse Nicotine Nicotine Dependence Paper Patient Recruitments Patients Peer Review Pharmaceutical Preparations Physicians Pilot Projects Positioning Attribute Primary Care Physician Primary Health Care Productivity Professional counselor Public Health Publications Research Research Personnel Research Project Grants Role Safety Schools Science Scientist Secure Services Shapes Smoker Smoking Structure Students Testing Time Tobacco Dependence Tobacco smoking behavior Tobacco use Traineeship Training Training Programs Translational Research Treatment Effectiveness United States National Institutes of Health Universities Use Effectiveness Work Writing base career career development experience implementation science improved next generation nicotine treatment nicotine use patient oriented patient oriented research personalized medicine preventable death programs recruit role model skills student mentoring symposium teacher training opportunity

项目摘要

Despite great progress over the past 50 years in reducing the rate of smoking, tobacco dependence remains a leading public health concern in the US. To ensure the sustained and impactful research effort dedicated to addressing tobacco dependence, rigorous and inter-disciplinary mentoring programs are needed to prepare the next generation of researchers committed to tobacco dependence patient-oriented research (POR). I have led a successful research program focused on the evaluation of methods to improve the use and effectiveness of treatments for nicotine dependence for ~20 years and, during this time, I have mentored 24 students, fellows, or junior faculty. This Mid-Career Investigator Award will be used to support 2 overarching career goals. First, to support my primary mentorship career goal, I will formalize and enhance the mentoring activities that I have been engaged in since 2001 into a structured, comprehensive, and impactful mentoring program in tobacco dependence POR for students, fellows, and junior faculty. This will involve: 1) the implementation of a formal mentoring framework for trainees with different academic levels, which will double the number of mentees vs. the past 5 years and markedly increase mentoring productivity and impact in terms of publications and grants; 2) strengthening a pipeline for mentee recruitment through new mechanisms such as T32s and TCORS; and 3) the recruitment and mentoring of 6 students, 4 fellows, and 3 junior faculty over the next 5 years, in addition to 5 current mentees (for a total of 18). My mentoring program will use NIDA's mentoring framework, and will: 1) focus on students and junior faculty to ensure that training begins early in a mentee's career; 2) provide individualized training based on mentee's goals and abilities; 3) provide short/intensive and long/sustained traineeships depending on the mentee; 4) offer training in inter-disciplinary science; and 5) offer intensive training in patient-oriented research (POR). To facilitate my career development, I will: 1) use a Mentoring Advisory Committee, comprised of faculty experienced with mentoring, 2) complete courses, conferences, and workshops in translational and implementation science and mentoring and leadership; and 3) join a Penn effort to enhance links between behavioral and primary care. Second, to support my primary research career goal, I will broaden my POR program to include translational and implementation science through a pilot study of the use of the nicotine metabolite ratio (NMR) for promoting clinician prescribing and patient use of treatments for nicotine dependence within primary care. Based on our work showing that personalizing nicotine dependence treatment using the NMR improves treatment effectiveness and safety, the pilot will assess the translational potential of this model within primary care, while providing opportunities for mentee training and facilitating a subsequent R01. This mid-career investigator award will markedly improve my past mentoring record, offer new opportunities for mentoring and career development, and enable the expansion of my POR program to include translational and implementation science.

尽管过去50年在降低吸烟率方面取得了很大进展，但烟草依赖仍然是一个问题