Integrated Biobanking Shared Resource

综合生物样本库共享资源

• 批准号: 10239119
• 负责人: Michael M Ittmann
• 金额: $ 28.8万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10239119
• 关键词: Acquired Immunodeficiency Syndrome; Animal Model; Animals; Basic Science; Biological Assay; Blood; Cancer Center; Cancer Center Support Grant; Cancer Model; Clinical; Clinical Data; Collaborations; Collection; Comprehensive Cancer Center; Consent; Consultations; DNA; Data; Databases; Development; Enrollment; Ensure; Epidemiology; Etiology; Formalin; Frozen Sections; Funding; Future; Genomics; Histology; Histopathology; Hospitals; Human; Human Resources; Image Analysis; Immunohistochemistry; Informed Consent; Investigation; Maintenance; Malignant Neoplasms; Medicine; Metagenomics; National Cancer Institute; Normal tissue morphology; Paraffin Embedding; Pathologic; Pathologist; Pathology; Peripheral Blood Mononuclear Cell; Play; Population Research; Population Sciences; Prevention; Proteomics; Questionnaires; Research; Research Activity; Research Personnel; Resource Sharing; Resources; Risk Factors; Role; Scanning; Science; Secure; Services; Slide; Specimen; Stains; Structure; Technology; Tissue Embedding; Tissue Microarray; Tissues; Training; Translational Research; Urine; Venous blood sampling; anticancer research; base; biobank; cancer specimen resource; cancer therapy; cell preparation; clinical care; college; epidemiologic data; experience; follow-up; histological stains; human tissue; in vivo; laser capture microdissection; metabolomics; microbiome; mouse model; multidisciplinary; multiplexed imaging; operation; optimal treatments; patient derived xenograft model; programs; tissue processing; transcriptomics; translational scientist; tumor

PROJECT SUMMARY: Integrated Biobanking Shared Resource (IBSR) The purpose of the Integrated Biobanking Shared Resource is to provide access to biospecimens by coordinated general and targeted biospecimen acquisition along with relevant expertise and technical resources to enhance basic, translational and clinical cancer biospecimen-based research activities at the Dan L. Duncan Comprehensive Cancer Center. Access to such resources is critical for biospecimen-based cancer investigations. This Shared Resource (SR) is a merger of the prior Human Tissue Acquisition and Pathology (HTAP) and the Population Sciences Biorepository (PSB) SRs into a single Integrated Biobanking SR (IBSR). This is a natural outgrowth of the close working relationship of the HTAP and PSB SRs over many years. Merger of HTAP and PSB SRs will allow us to further integrate our operations within a common management structure. The Shared Resource personnel have extensive experience in pathology, epidemiology, biospecimen acquisition and processing, bank maintenance and distribution. In addition, personnel are trained in the various technical services offered including peripheral blood mononuclear cell preparation, DNA extraction, routine histology services, frozen sections, tissue microarray construction, immunohistochemistry, tissue microarray scanning, and multiplex image analysis. We also provide pathology consultation by expert pathologists for both human tissue specimens and mouse models, and risk factor questionnaire development and collection.

项目总结：综合生物库共享资源（IBSR） 综合生物库共享资源的目的是通过以下方式提供对生物样本的访问 协调一般和有针对性的生物标本采集，沿着相关专业知识和技术 资源，以加强基础，转化和临床癌症生物医学为基础的研究活动，在丹 L.邓肯综合癌症中心。获得这些资源对于生物制药癌症至关重要 调查事务所此共享资源（SR）是先前的人体组织采集和病理学的合并 （HTAP）和人口科学生物储存库（PSB）SR合并为单个综合生物库SR（IBSR）。 这是HTAP和PSB员工代表多年来密切工作关系的自然结果。 HTAP和PSB SR的合并将使我们能够在共同的管理中进一步整合我们的业务 结构共享资源人员在病理学，流行病学， 生物标本的获取和处理、库的维护和分发。此外，还对人员进行培训， 在提供的各种技术服务中，包括外周血单核细胞制备、DNA 提取，常规组织学服务，冷冻切片，组织微阵列构建，免疫组织化学， 组织微阵列扫描和多重图像分析。我们还提供专家病理咨询 病理学家为人类组织标本和小鼠模型，并制定风险因素问卷 和收藏。