SBIR Phase I Topic 407 - Cloud-Based Software for the Cancer Research Data Commons.

SBIR 第一阶段主题 407 - 用于癌症研究数据共享的基于云的软件。

• 批准号: 10248279
• 负责人: PAUL DAVE
• 金额: $ 25.19万
• 依托单位: NAVIPOINT GENOMICS, LLC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-16 至 2021-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10248279
• 关键词: Adoption; Area; Bioinformatics; Computer software; Data Commons; Development Plans; Diagnosis; Malignant Neoplasms; Phase; Prevention; Resources; Small Business Innovation Research Grant; System; Systems Development; analytical tool; anticancer research; cloud based; data resource; improved; precision oncology; prototype; tool; usability

Precision oncology offers great potential in improving cancer-related diagnosis and treatment. The Navipoint Platform provides state of the art tools, pipelines, and cloud-based resources, which will be extended and integrated with CRDC data and resources in order to enable “Collaborate in the Cloud” capabilities to help realize this promise. The product of this SBIR will be a prototype system demonstrating the integration between Navipoint and CRDC. The proposed approach includes the following: To develop, leverage and disseminate commercial analytical tools in the Navipoint bioinformatics analysis platform that can seamlessly integrate with, and fully leverage, CRDC resources in order to help drive new cancer discoveries for improved prevention, diagnosis and treatment. To build a prototype system that extends and integrates the Navipoint Platform with CRDC through adoption of the Data Commons Framework to support several cancer-specific analysis and multi-domain use-cases. And to perform a usability study with a cross-section of users to validate capabilities of the prototype system and document areas of improvement.

精准肿瘤学在改善癌症相关诊断和治疗方面具有巨大潜力。Navipoint平台提供最先进的工具、管道和基于云的资源，这些资源将与CRDC数据和资源进行扩展和集成，以实现“云中协作”功能，帮助实现这一承诺。该SBIR的产品将是一个原型系统，演示Navipoint和CRDC之间的集成。建议的方法包括：在Navipoint生物信息学分析平台中开发、利用和传播商业分析工具，这些工具可以与CRDC资源无缝集成并充分利用CRDC资源，以帮助推动新的癌症发现，从而改善预防、诊断和治疗。建立一个原型系统，通过采用数据共享框架扩展和集成Navipoint平台与CRDC，以支持多个癌症特异性分析和多领域用例。并对用户进行可用性研究，以验证原型系统的功能，并记录改进的领域。