Identifying the neurobehavioral signature of individuals with AUD and comorbid PTSD

识别患有 AUD 和共病 PTSD 的个体的神经行为特征

• 批准号: 10245141
• 负责人: Amber Jarnecke
• 金额: $ 20.35万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10245141
• 关键词: Address; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Amber; Amygdaloid structure; Area; Back; Basic Science; Behavior; Behavior Therapy; Behavioral; Behavioral Mechanisms; Behavioral Research; Biomedical Research; Cause of Death; Clinical; Clinical Research; Cognition; Complex; Corpus striatum structure; Data; Data Analyses; Decision Making; Development; Disease; Emotional; Empirical Research; Employment; Ensure; Foundations; Functional Magnetic Resonance Imaging; Future; Goals; Grant; HIV risk; Habits; Human; Impairment; Individual; Institutes; Intervention; Investigation; Knowledge; Laboratories; Legal; Literature; Magnetic Resonance; Maintenance; Medical; Medical Economics; Mental Depression; Mental Health; Mentored Patient-Oriented Research Career Development Award; Mentorship; Methodology; Mission; Motivation; Neurobiology; Pathway interactions; Perception; Personality; Play; Post-Traumatic Stress Disorders; Prefrontal Cortex; Prognosis; Psychologist; Public Health; Relapse; Research; Research Design; Research Personnel; Research Project Grants; Rest; Rewards; Risk Behaviors; Scientist; Series; Sex Differences; Sleep; Solid; South Carolina; Statistical Data Interpretation; Strategic Planning; Symptoms; Techniques; Training; Translating; Treatment outcome; United States; Universities; Ventral Striatum; Withdrawal; Writing; alcohol comorbidity; alcohol cue; alcohol research; alcohol use disorder; base; behavioral disinhibition; behavioral phenotyping; behavioral response; career; career development; comorbidity; cost; craving; design; effective intervention; effective therapy; executive function; experience; high risk; individual response; interest; negative affect; neural circuit; neurobehavioral; neurobiological mechanism; neuroimaging; neuromechanism; novel; patient oriented research; physical conditioning; prevent; programs; psychosocial; reduce symptoms; relating to nervous system; response; responsible research conduct; skills; suicidal risk

The overall aim of the proposed K23 Mentored Patient-Oriented Research Career Development Award is to allow Dr. Amber Jarnecke to develop new knowledge and research skills in (1) alcohol use disorders (AUD) and co-occurring mental health conditions, in particular, posttraumatic stress disorder (PTSD); and (2) the application of neuroimaging and human laboratory paradigms to investigate AUD and PTSD. Research demonstrates that individuals with comorbid AUD and PTSD have a more severe clinical presentation; more psychosocial, legal, medical and economic problems; and poorer treatment outcomes as compared to individuals with either disorder alone. Despite the frequent co-occurrence and deleterious consequences associated with comorbid AUD and PTSD, research on effective treatments for this comorbidity is sparse, and empirical data is critically needed to inform the development of effective interventions. Investigation of the neural circuitry and behavioral responses underlying comorbid AUD and PTSD may help develop a more thorough understanding of this common comorbidity, and identify viable treatment targets for future interventions. The candidate is a clinical psychologist with a strong background in research design, statistical analysis, and behavioral interventions for AUD. Under the proposed K23 award, she aims to obtain new knowledge and research skills in order to advance toward her long-term career goal of becoming an independent investigator conducting patient-oriented research, able to translate findings from basic research into new treatments that target the underlying neurobiological mechanisms of AUD and comorbid conditions, such as PTSD. To that end, the candidate's immediate career goals under the proposed K23 are to: (1) develop a solid foundation in the neurobiology of AUD and PTSD; (2) obtain experience in advanced neuroimaging techniques and data analysis in order to better understand the AUD/PTSD neurobiological interface; (3) become proficient in the conduct of human laboratory paradigms; (4) continue training in the responsible conduct of research, and (5) enhance her scientific and grant writing skills. Under the mentorship of outstanding investigators (Drs. Sudie Back, Jane Joseph, and Kathleen Brady at the Medical University of South Carolina and Dr. Rajita Sinha at Yale University), the candidate will employ task-based functional magnetic resonance imaging (fMRI) to investigate the neurobehavioral responses of individuals with comorbid AUD and PTSD. The mentorship and training afforded by the proposed K23 award will significantly enhance the candidate's career development in the area of patient-oriented research focused on AUD and comorbid PTSD. The combination of outstanding mentorship, hands-on experience, didactics and formal coursework will provide a rich training experience and critical preliminary data to support future R-series applications. This K23 application is directly responsive to the mission of NIAAA and the strategic plan to understand, prevent, and treat AUD and co-occurring mental health conditions.

拟议的K23以患者为导向的研究职业发展奖的总体目标是 允许安珀·雅内克博士在(1)酒精使用障碍(AUD)方面发展新知识和研究技能 和共同发生的精神健康状况，特别是创伤后应激障碍(PTSD)；和(2) 应用神经成像和人体实验室范例研究AUD和PTSD。研究 表明患有AUD和PTSD的人有更严重的临床表现；更多 心理社会、法律、医疗和经济问题；与 单独患有任何一种障碍的人。尽管频繁的共生和有害的后果 与AUD和PTSD共病相关的有效治疗方法的研究很少，而且 为制定有效的干预措施，迫切需要经验数据。对这一事件的调查 共同患有AUD和PTSD的神经回路和行为反应可能有助于发展更多的 彻底了解这种常见的合并症，并确定未来可行的治疗目标 干预措施。应聘者为临床心理学家，在研究设计、统计学方面有很强的背景。 分析，并对澳元病进行行为干预。根据拟议的K23奖项，她的目标是获得新的 知识和研究技能，以便向她成为一名 独立调查员进行以患者为中心的研究，能够将基础研究的结果转化为 转化为针对AUD和共病条件的潜在神经生物学机制的新疗法， 比如创伤后应激障碍。为此，候选人在拟议的K23下的近期职业目标是：(1) 在AUD和创伤后应激障碍的神经生物学方面打下坚实的基础；(2)在 神经影像技术和数据分析，以更好地了解AUD/PTSD的神经生物学 界面；(3)精通人类实验室范例的实施；(4)继续培训 负责任地进行研究，以及(5)提高她的科学和拨款撰写技能。在导师的指导下 杰出研究人员(华盛顿医科大学的苏迪·巴克博士、简·约瑟夫博士和凯瑟琳·布雷迪博士 南卡罗来纳州和耶鲁大学的Rajita Sinha博士)，候选人将采用基于任务的功能 磁共振成像(FMRI)研究共病个体的神经行为反应 澳元和创伤后应激障碍。拟议的K23奖项提供的指导和培训将大大增强 应聘者在以患者为中心的研究领域的职业发展侧重于AUD和共病 创伤后应激障碍。出色的指导、实践经验、教学方法和正规课程将结合在一起 提供丰富的培训经验和关键的初步数据，以支持未来的R系列应用。这个K23 应用直接响应NIAAA的使命和战略计划，以了解、预防和 治疗AUD和共生的精神健康问题。