Sliding vertex behaviors during epithelial morphogenesis and tissue elongation
上皮形态发生和组织伸长期间的滑动顶点行为
基本信息
- 批准号:10245156
- 负责人:
- 金额:$ 29.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-20 至 2022-08-31
- 项目状态:已结题
- 来源:
- 关键词:ActomyosinAddressAdhesionsAdultApicalArchitectureAreaArea AnalysesBehaviorBiologicalBiophysicsCarcinomaCell AdhesionCell AgingCell physiologyCellsCochleaCommunitiesComplexContractile ProteinsContractsCoupledCouplingCytoskeletonDataDevelopmentDevelopmental ProcessDimensionsDrosophila genusE-CadherinEmbryoEmbryonic DevelopmentEnvironmentEpithelialEventF-ActinGoalsIndividualIntentionLeadLengthLinkMaintenanceMechanicsMedialMediatingMethodsModelingMolecularMorphogenesisMorphologyMovementMyosin Type IINeoplasm MetastasisOrganOrganismPalatePhasePhysiologic pulsePopulationProcessProtein AnalysisProteinsRadialRelaxationResearchResolutionShapesSlideStretchingStructureSystemTestingTissuesbasebiophysical analysisbiophysical toolscell motilitycourse developmentintercalationnovelnovel strategiesspatiotemporaltissue repairtool
项目摘要
Project Summary
Epithelial sheets sit at the boundary of the organism and its external environment. The
maintenance of these apical and basolateral domains is essential to the barrier function
of epithelia, and the loss of apical-basal polarity is associated with the metastasis of
many epithelial cancers. While epithelial sheets were once viewed as largely static
assemblies, it is now appreciated that these are dynamic structures that can undergo
significant reorganizing and renewal events. Indeed, cell neighbor exchange can be
harnessed by developmental processes to effect changes in tissue architecture, and cell
intercalation can drive epithelial tissue repair. In the Drosophila embryonic epithelium,
individual cells are able to either consolidate cell-cell contacts or direct neighbor
exchange movements through the contraction of vertical T1 interfaces and the
subsequent resolution of horizontal T3 interfaces. The dominant model in explaining
these behaviors has been one in which line tensions that stretch across interfaces direct
these changes. However, a number of observations have led us to question this
approach. Our central hypothesis is that cell vertices demonstrate radial coupling and
that the best explanation of intercalary behaviors will be through a description of the
radially-directed force events that lead to vertex movements and subsequent dependent
changes in interface lengths. Our data suggests that tricellular vertices slide along cell-
cell interfaces to harness radial forces, and would introduce a new area of research on
the molecular and biophysical contributions of cell vertices to embryogenesis. Pulsed
oscillations in cell area have been found to drive developmental processes in a number
of different systems and tissues, but the mechanisms that link these area oscillations to
productive tissue shaping events have been unclear. Because of this, we believe vertex
sliding through radial force coupling offers a new, fundamental mechanism that may
account for this conservation of oscillatory mechanics. We also will examine the
structure and oscillation of adhesion complexes that are located at cell vertices, as well
as the relationship between actomyosin forces and changes in vertex structure. We
believe the proposed studies will provide a fundamentally new vertex-based mechanism
that directs cell intercalation through junctional sliding driven by radial coupling.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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James Todd Blankenship其他文献
James Todd Blankenship的其他文献
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{{ truncateString('James Todd Blankenship', 18)}}的其他基金
Volumetric analysis of epithelial morphogenesis with high spatiotemporal resolution
高时空分辨率上皮形态发生的体积分析
- 批准号:
10586534 - 财政年份:2023
- 资助金额:
$ 29.49万 - 项目类别:
Control of cell ratcheting engagement during epithelial morphogenesis
上皮形态发生过程中细胞棘轮啮合的控制
- 批准号:
10544507 - 财政年份:2022
- 资助金额:
$ 29.49万 - 项目类别:
Control of cell ratcheting engagement during epithelial morphogenesis
上皮形态发生过程中细胞棘轮啮合的控制
- 批准号:
10366809 - 财政年份:2022
- 资助金额:
$ 29.49万 - 项目类别:
Sliding vertex behaviors during epithelial morphogenesis and tissue elongation
上皮形态发生和组织伸长期间的滑动顶点行为
- 批准号:
9789335 - 财政年份:2018
- 资助金额:
$ 29.49万 - 项目类别:
Mechanisms of membrane ratcheting during cell intercalation
细胞嵌入过程中膜棘轮机制
- 批准号:
9440874 - 财政年份:2017
- 资助金额:
$ 29.49万 - 项目类别:
Dynamics of Epithelial Polarity Proteins and the Control of Tissue Architecture
上皮极性蛋白的动力学和组织结构的控制
- 批准号:
8309149 - 财政年份:2011
- 资助金额:
$ 29.49万 - 项目类别:
Dynamics of Epithelial Polarity Proteins and the Control of Tissue Architecture
上皮极性蛋白的动力学和组织结构的控制
- 批准号:
8042519 - 财政年份:2011
- 资助金额:
$ 29.49万 - 项目类别:
Dynamics of Epithelial Polarity Proteins and the Control of Tissue Architecture
上皮极性蛋白的动力学和组织结构的控制
- 批准号:
8423865 - 财政年份:2011
- 资助金额:
$ 29.49万 - 项目类别:
Dynamics of Epithelial Polarity Proteins and the Control of Tissue Architecture
上皮极性蛋白的动力学和组织结构的控制
- 批准号:
8912482 - 财政年份:2011
- 资助金额:
$ 29.49万 - 项目类别:
Dynamics of Epithelial Polarity Proteins and the Control of Tissue Architecture
上皮极性蛋白的动力学和组织结构的控制
- 批准号:
8535168 - 财政年份:2011
- 资助金额:
$ 29.49万 - 项目类别:
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