Administrative Core

行政核心

• 批准号: 10247785
• 负责人: Wendy Demark-Wahnefried
• 金额: $ 19.14万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10247785
• 关键词: Accelerometer; Achievement; Adverse event; Advocate; Aging; Amendment; Behavior Therapy; Behavioral; Behavioral Model; Biological Markers; Body Water; Body Weight; Body Weight decreased; Cancer Survivor; Cellular Phone; Certification; Clinical Trials Data Monitoring Committees; Collaborations; Collection; Communication; Computers; Cost Analysis; Data; Data Pooling; Databases; Devices; Diet; Dimensions; Dissemination and Implementation; Doctor of Philosophy; Effectiveness; Ensure; Exercise; Foundations; Goals; Grant; Health; Health Care Costs; Health Food; Health behavior; Health behavior change; Incentives; Inflammation; Infrastructure; Institutional Review Boards; Interferon Type II; Interleukin-6; Internet; Intervention; Lead; Leadership; Link; Measures; Modeling; Monitor; Outcome; Oxidative Stress; Participant; Patients; Personal Satisfaction; Physical Function; Physical Performance; Physical activity; Population; Process; Progress Reports; Protocols documentation; Quality Control; Quality of life; Quality-Adjusted Life Years; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; Resources; Rural Minority; Services; Shipping; Ships; Specialist; Structure; Sum; Survivors; Tablet Computer; Technology; Telomerase; Training; Training Support; Treatment Efficacy; Triage; Weight maintenance regimen; Work; behavior change; cancer type; cost; cost effective; cost effectiveness; driving behavior; efficacious intervention; efficacy testing; experience; human subject; immunological status; implementation science; improved; lean body mass; meetings; multidisciplinary; programs; secondary analysis; social cognitive theory; survivorship; synergism; theories; underserved minority

The primary objective of the Administrative (Admin) Shared Resource Core (SRC) is to provide the foundation for integration, coordination, and management of all components of AMPLIFI, (i.e., the three research projects and three additional SRCs). The Admin SRC also is responsible for all budgetary and regulatory activities (processing incentives, IRB clearance and amendments, coordinating DSMB oversight, etc.) and work required for all program components. In addition, the Admin SRC team will arrange for meetings amongst the investigators, and perform the majority of supply shipment, as well as file progress reports. As part of the supplies, the Admin SRC will provide computer tablets and internet service coverage to any study participants who do have current internet access via computers, smartphones or other devices; the IT specialist within this SRC also will provide training and guidance for participants who require this support in order to participate fully in the 3 projects. This SRC also will maintain the study toll-free number and will track, triage, and report any adverse events, and also will coordinate annual DSMB reviews. The Specific Aims are to: (1) Integrate overarching program aims with project-specific outcomes; (2) Coordinate the activities of the research projects and resource cores to ensure that the AMPLIFI goals and outcomes are achieved; and (3) Lead effective management and scientific integration of AMPLIFI components. Using a comprehensive approach, we will leverage our shared resource cores and infrastructure to accomplish the following: 1) identify how best to reach underserved older, rural, and minority cancer survivors; 2) engage survivors in exercising more and making healthier food choices that result in improved diet quality and weight control; 3) determine whether behavioral interventions in specific domains should be presented sequentially or simultaneously in this population; and assess the cost-effectiveness of the adapted health behavior interventions. Thus, the proposed work is integrated and synergistic across multiple dimensions to leverage research infrastructure, collaborative relationships, and the investigators' expertise to achieve greater outcomes compared to the sum of the differential parts.

管理（Admin）共享资源核心（SRC）的主要目标是提供基础 用于整合、协调和管理 AMPLIFI 的所有组成部分（即三个研究项目 和三个额外的 SRC）。行政 SRC 还负责所有预算和监管活动 （处理激励措施、IRB 许可和修订、协调 DSMB 监督等）和所需工作 对于所有程序组件。此外，SRC 管理团队将安排 SRC 成员之间的会议 调查员，并执行大部分供应运输，并提交进度报告。作为 用品，Admin SRC 将为所有研究参与者提供平板电脑和互联网服务覆盖 目前可以通过计算机、智能手机或其他设备访问互联网的人；该领域的 IT 专家 SRC 还将为需要这种支持才能充分参与的参与者提供培训和指导 在3个项目中。该 SRC 还将维护研究免费电话号码，并将跟踪、分类和报告任何 不良事件，还将协调年度 DSMB 审查。 具体目标是： (1) 将总体计划目标与项目具体成果相结合； (2) 协调研究项目和资源核心的活动，以确保 AMPLIFI 目标和 取得成果； (3) 领导AMPLIFI组件的有效管理和科学集成。 我们将采用综合方法，利用我们共享的资源核心和基础设施来实现 以下内容： 1) 确定如何最好地帮助服务不足的老年人、农村和少数民族癌症幸存者； 2）参与 幸存者进行更多锻炼并选择更健康的食物，从而改善饮食质量和体重 控制; 3）确定特定领域的行为干预是否应按顺序提出或 同时在这个人群中；并评估适应的健康行为的成本效益 干预措施。因此，所提出的工作是跨多个维度的集成和协同作用，以利用 研究基础设施、合作关系和研究人员的专业知识，以实现更大的目标 结果与不同部分的总和进行比较。