Internet-Based Lifestyle Intervention to Eradicate Obese Frailty in Prostate Cancer Survivors (iLIVE)

基于互联网的生活方式干预,消除前列腺癌幸存者的肥胖虚弱 (iLIVE)

基本信息

项目摘要

Over 1 million men in the U.S. are receiving androgen deprivation therapy (ADT) to prevent prostate cancer progression. Although a critical therapeutic strategy, ADT increases the risk of frailty, weight gain and obesity in prostate cancer survivors (PCS). In our recent study, the odds of PCS having both obesity plus frailty, i.e., obese frailty, were 19x higher in ADT users compared to non-users and obese frailty was a significant and stronger predictor of recurrent falls than frailty alone. Thus, interventions are urgently needed to mitigate the obese frailty in PCS that threatens independence and quality of life and which multiplies health care costs. However, there are currently no effective interventions in clinical practice for PCS that target obese frailty as a clinical endpoint. Given that the number of PCS on ADT is growing by over 30,000 each year, there is a critical need to develop scalable interventions with high reach potential to address this urgent practice gap and rising public health issue. The co-principal investigators for this application each have strong prior work demonstrating efficacy for reducing obesity via online dietary intervention and frailty via online supervised resistance training, respectively. The urgent need to address obese frailty in PCS on ADT now supports combining these interventions into a single, scalable online program. To advance this work toward clinical practice, our strong multidisciplinary team of experts in nutrition, exercise science, urology, oncology, behavioral theory, health economics, and implementation science, proposes a 2-arm parallel group randomized Type I hybrid effectiveness-implementation trial focused on obese frailty in PCS on ADT. This design allows formal testing of the effectiveness of a combined online, self-directed weight loss + group-based resistance training program (Internet-Based Lifestyle Intervention to Eradicate Obese Frailty in Prostate Cancer Survivors: iLIVE) against usual care with obese frailty as a primary endpoint. Our Primary Aim is to compare iLIVE to UC on obese frailty in 250 PCS on ADT over a 6-month period. Secondary Aims are to: a) Compare the effect of iLIVE to UC on secondary outcomes, e.g., individual frailty criterion, dietary quality, physical function, quality of life; b) Assess the durability of iLIVE to UC by comparing groups at 12-month follow-up; and c) Explore potential moderators (e.g., age, race, BMI) associated with intervention effectiveness. Finally, our Tertiary Aim is to: Assess key implementation outcomes (e.g., cost, acceptability) to guide future research regarding the implementation of iLIVE into the clinical care pathway. iLIVE builds on a solid foundation of diet and exercise interventions in cancer survivors with proven efficacy, and the proposed Type I hybrid effectiveness-implementation trial is designed to speed effectiveness testing and optimization and ultimately enable reductions in morbidity and mortality for over 1 million older PCS across the nation.
在美国,超过100万男性正在接受雄激素剥夺治疗(ADT)以预防前列腺癌。 进展虽然ADT是一种关键的治疗策略,但它会增加虚弱、体重增加和肥胖的风险 前列腺癌幸存者(PCS)。在我们最近的研究中,PCS同时具有肥胖和虚弱的几率,即, ADT使用者的肥胖虚弱,是非使用者的19倍,肥胖虚弱是一个显著的, 比单纯虚弱更能预测复发性福尔斯。因此,迫切需要采取干预措施, PCS中的肥胖虚弱,威胁独立性和生活质量,并使医疗保健费用成倍增加。 然而,在临床实践中,目前还没有针对肥胖虚弱的PCS的有效干预措施, 临床终点鉴于ADT上的PCS数量每年增长超过30,000, 需要制定具有高覆盖潜力的可扩展干预措施,以解决这一紧迫的实践差距, 公共卫生问题。该应用程序的共同主要研究者都有很强的前期工作 通过在线饮食干预证明减少肥胖的有效性,通过在线监督 分别进行阻力训练。现在迫切需要解决ADT上PCS中的肥胖脆弱性, 将这些干预措施整合到一个单一的、可扩展的在线项目中。为了将这项工作推向临床 实践,我们强大的多学科专家团队在营养,运动科学,泌尿科,肿瘤学, 行为理论,卫生经济学和实施科学,提出了一个双臂平行组 随机I型混合有效性-实施试验,重点关注ADT治疗PCS中的肥胖虚弱。这 设计允许正式测试的有效性相结合的在线,自我导向的减肥+基于组 抵抗力训练计划(基于互联网的生活方式干预,以消除前列腺肥胖脆弱 癌症幸存者:iLIVE)与以肥胖虚弱作为主要终点的常规护理相比。我们的主要目标是 比较iLIVE与UC在6个月内接受ADT治疗的250例肥胖虚弱患者中的疗效。第二个目标是:a) 比较iLIVE与UC对次要结局的影响,例如,个体虚弱标准,膳食质量, 身体功能、生活质量; B)通过比较12个月时的组,评估iLIVE对UC的持久性 跟进;以及c)探索潜在的主持人(例如,年龄、种族、BMI)与干预效果相关。 最后,我们的第三个目标是:评估关键的实施成果(例如,成本,可接受性),以指导未来 关于将iLIVE应用于临床护理路径的研究。iLIVE建立在一个坚实的 在癌症幸存者中建立饮食和运动干预的基础,并证明其有效性,以及拟议的I型 混合有效性-实施试验旨在加速有效性测试和优化, 最终能够降低全国100多万老年PCS的发病率和死亡率。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Wendy Demark-Wahnefried其他文献

Wendy Demark-Wahnefried的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Wendy Demark-Wahnefried', 18)}}的其他基金

Adapting MultiPLe behavior Interventions that eFfectively Improve (AMPLIFI) Cancer Survivor Health
适应多种行为有效改善 (AMPLIFI) 癌症幸存者健康的干预措施
  • 批准号:
    10318887
  • 财政年份:
    2021
  • 资助金额:
    $ 58.76万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10247785
  • 财政年份:
    2018
  • 资助金额:
    $ 58.76万
  • 项目类别:
Adapting MultiPLe behavior Interventions that eFfectively Improve (AMPLIFI) Cancer Survivor Health
适应多种行为有效改善 (AMPLIFI) 癌症幸存者健康的干预措施
  • 批准号:
    10247730
  • 财政年份:
    2018
  • 资助金额:
    $ 58.76万
  • 项目类别:
Project 1: RENEWeb: Reaching-out to ENhance diet and Weight Control via the Web in Cancer Survivors
项目 1:RENEWeb:通过网络加强癌症幸存者的饮食和体重控制
  • 批准号:
    10247779
  • 财政年份:
    2018
  • 资助金额:
    $ 58.76万
  • 项目类别:
Adapting MultiPLe behavior Interventions that eFfectively Improve (AMPLIFI) Cancer Survivor Health
适应多种行为有效改善 (AMPLIFI) 癌症幸存者健康的干预措施
  • 批准号:
    9581203
  • 财政年份:
    2018
  • 资助金额:
    $ 58.76万
  • 项目类别:
Adapting MultiPLe behavior Interventions that eFfectively Improve (AMPLIFI) Cancer Survivor Health
适应多种行为有效改善 (AMPLIFI) 癌症幸存者健康的干预措施
  • 批准号:
    10679027
  • 财政年份:
    2018
  • 资助金额:
    $ 58.76万
  • 项目类别:
Harvest for Health in Older Cancer Survivors
老年癌症幸存者的健康收获
  • 批准号:
    10197801
  • 财政年份:
    2016
  • 资助金额:
    $ 58.76万
  • 项目类别:
Vegetable garden feasibility trial to promote function in older cancer survivors
菜园可行性试验促进老年癌症幸存者的功能
  • 批准号:
    8619527
  • 财政年份:
    2014
  • 资助金额:
    $ 58.76万
  • 项目类别:
Exploring Effects of Weight Loss on Ductal Carcinoma In Situ
探索减肥对导管原位癌的影响
  • 批准号:
    8701513
  • 财政年份:
    2014
  • 资助金额:
    $ 58.76万
  • 项目类别:
Exploring Effects of Weight Loss on Ductal Carcinoma In Situ
探索减肥对导管原位癌的影响
  • 批准号:
    8827301
  • 财政年份:
    2014
  • 资助金额:
    $ 58.76万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 58.76万
  • 项目类别:
    Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 58.76万
  • 项目类别:
    Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 58.76万
  • 项目类别:
    Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 58.76万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 58.76万
  • 项目类别:
    Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 58.76万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 58.76万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 58.76万
  • 项目类别:
    EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 58.76万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 58.76万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了