Core D: Clinical Core

核心 D：临床核心

• 批准号: 10247714
• 负责人: Evan Yu
• 金额: $ 5.63万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-19 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10247714
• 关键词: Advocacy; Advocate; Affect; Area; Autopsy; Awareness; Basic Science; Biological Specimen Banks; Biostatistics Core; Blood; British Columbia; Budgets; Caring; Clinical; Clinical Data; Clinical Research; Clinical Trials; Clinical Trials Design; Collection; Communities; Community Outreach; Conduct Clinical Trials; Contracts; Counseling; Data; Data Analyses; Data Reporting; Development; Enrollment; Ensure; Health Sciences; Human; Informed Consent; Institution; Intervention Trial; Link; Malignant neoplasm of prostate; Metastatic Prostate Cancer; Minority; Mission; Monitor; Neoplasm Metastasis; Oregon; Pacific Northwest; Patient Outcomes Assessments; Patient Recruitments; Patients; Population; Population Research; Prevention; Program Development; Protocols documentation; Province; Regulation; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Secure; Site; Specimen; Support Groups; System; Time; Translational Research; Universities; Update; Urine; Washington; Work; anticancer research; base; cancer clinical trial; career; career development; clinical data repository; clinical database; clinical research site; clinical trial participant; community planning; design; follow-up; genomic data; improved; meetings; men; open source; patient oriented; programs; prostate biopsy; prostate cancer risk; prostate lesions; protocol development; recruit; repository; research study; trial design; tumor

PROJECT SUMMARY/ABSTRACT This Clinical Core is specifically designed and supported with the objective of facilitating the translational mission of the Pacific Northwest (PNW) Prostate Cancer SPORE. Each of the five major projects directly utilizes patient- derived materials and attendant clinical data, and most are designed with a patient-directed interventional trial. However, there are major barriers between clinical, basic and population-based research that constrain progress; thus, the Aims of this Core were formulated to assist the major projects, developmental projects, and career development awardees in the rapid advancement of their research objectives. The Clinical Core has the following Specific Aims: Specific Aim 1: To design, execute, accrue to, and otherwise facilitate the conduct and timely completion of human clinical trials relevant to SPORE translational science. The Clinical Core will support major research projects, developmental research studies, and clinical trials related to the Career Enhancement Program. Specific Aim 2: To design, direct, and assist with patient recruitment for biospecimen acquisition. Specific Aim 3: To direct, support, and enhance CAISIS (repository of clinical and patient-reported data) to support clinical and translational prostate cancer research across the SPORE sites. Specific Aim 4: To ensure that SPORE Major and Developmental Projects maintain a patient-centered focus, we will support and engage the SPORE Advocacy Committee in the activities of the SPORE.

项目摘要/摘要 该临床核心是专门设计和支持的，目的是促进转化任务 西北太平洋（PNW）前列腺癌孢子。五个主要项目中的每个项目都直接利用患者 - 派生的材料和随之而来的临床数据，大多数是通过患者指导的介入试验设计的。 但是，限制进步的临床，基本和基于人群的研究之间存在主要障碍。 因此，该核心的目的是为了协助主要项目，发展项目和职业而制定的 发展目标的快速发展。 临床核心具有以下特定目标： 特定目的1：设计，执行，累积并以其他方式促进行为和及时完成 与孢子转化科学相关的人类临床试验。临床核心将支持 主要的研究项目，发展研究和与 职业增强计划。 具体目标2：设计，指导和协助患者招募生物胶囊获取。 特定目的3：指导，支持和增强CAISIS（临床和患者报告的数据存储库） 支持跨孢子部位的临床和转化前列腺癌研究。 特定目标4：确保孢子专业和发展项目保持以患者为中心的重点， 我们将支持并参与孢子倡导委员会参与孢子的活动。