Novel application of isoxazoline veterinary drugs to streamline reservoir-targeted abatement of tick-borne zoonoses

异恶唑啉兽药在简化针对宿主的蜱传人畜共患病防治中的新应用

基本信息

批准号：
10247046
负责人：
Jefferson Archer Vaughan
金额：
$ 17.46万
依托单位：
UNIVERSITY OF NORTH DAKOTA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10247046
关键词：
Abate Address Animals Appearance Back Black-legged Tick Borrelia Borrelia burgdorferi Borrelia miyamotoi Canis familiaris Centers for Disease Control and Prevention (U.S.)Disease Dose Drug Monitoring Felis catus Fleas Formulation Funding Geography Goals Great Plains Hour Human Incidence Laboratories Lyme Disease Microtus Mission Monitor North Dakota Nymph Oral Order Spirochaetales Peromyscus Pest Control Pharmaceutical Preparations Pharmacotherapy Pilot Projects Property Reporting Research Residual state Rodent Science Scientist Site Speed Spirochaetales Infections Strategic Planning System Technology Tick Control Tick-Borne Diseases Ticks Time Topical application Toxic effect United States National Institutes of Health Vector-transmitted infectious disease Veterinary Medicine White-Footed Mouse Work Zoonoses acaricide cohort design disorder prevention drug market efficacy evaluation efficacy testing field study fipronil improved novel parasitism pathogenic bacteria prophylactic protective effect success tick feeding tick population tick transmission tick-borne tick-borne pathogen transmission process vector control vector tick

项目摘要

Tick-borne diseases are of increasing importance in the USA. The majority (75%) of vector-borne diseases is tick-borne, the number of human tick-borne illnesses is steadily increasing, the geographic range of known tick vectors is expanding, and at least seven new tick-borne pathogens have been shown to infect people in the USA within the last two decades. All tick-borne diseases are zoonotic and perpetuation of tick-borne diseases depends on tick parasitism of non-human vertebrate reservoirs. In the USA, the vertebrate reservoirs for human tick-borne disease are primarily rodents. Effective strategies targeting rodent reservoirs are needed to help break the zoonotic transmission cycles and lower the incidence of tick-borne diseases in the USA. This proposal addresses that need by taking advantage of recent advances in veterinary medicine. A new class of orally-administered veterinary drug marketed for dogs (i.e., isoxazoline drugs) displays fast-acting, long-lasting acaricidal activity against ticks that feed on isoxazoline-treated animals. Because of the speed by which these drugs kill ticks after attaching to treated animals, isoxazoline drugs can also block tick transmission of bacterial pathogens to treated dogs. This pilot project will test the efficacy and transmission-blocking abilities of these drugs when given orally to two species of rodents known to be natural reservoirs of Lyme disease in North Dakota – the white-footed mouse and the red-backed vole. If orally administered isoxazoline drugs work in these rodent reservoir species as well as has been reported in dogs, then the stage will be set to seek funds for a larger R01 project and implement a regional-wide field trial, incorporating isoxazoline drugs in an oral bait formulation to rid rodent reservoirs of their ticks, disrupt zoonotic transmission cycles, and contain the westward spread of Lyme disease across North Dakota.

在美国，tick传播疾病的重要性越来越高。大多数（75％）媒介疾病是 tick传播，人类tick传播疾病的数量正在稳步增加，已知tick的地理范围向量正在扩展，至少有七个新的tick传播病原体已被证明是感染了在过去的二十年中。所有tick传播疾病都是人畜共患病，tick虫疾病的永久性取决于非人类脊椎动物水库的壁虱寄生虫。在美国，脊椎动物的水库人tick虫疾病是主要啮齿动物。需要针对啮齿动物储层的有效策略帮助破坏人畜共患循环，并降低美国tick传播疾病的事件。这提案通过利用兽医医学的最新进展来解决需求。一个新的类口服的兽医药物销售的狗（即，异恶唑啉药物）显示快速效果，持久杀菌活性，反对以异沙唑治疗的动物为食的壁虱。因为这些速度药物在附着在治疗的动物上后杀死壁虱，去唑啉药物也可以阻止细菌的tick虫传播病原体治疗的狗。该试点项目将测试这些试点的效率和传输障碍能力药物在口服两种啮齿动物时，已知是北方莱姆病天然储层的药物达科他州 - 白脚的老鼠和红色的vole。如果口服施用的异恶唑啉药物在这些啮齿动物的水库物种以及狗的报道，然后将阶段寻求资金对于更大的R01项目并实施区域范围的现场试验，将异恶唑啉药物纳入口服诱饵构成以摆脱啮齿动物的滴答，破坏人畜共形传播周期，并包含莱姆病向西传播北达科他州。