UM CFAR SCCC Argentina Consortium for research and training in Virally Induced AIDS Malignancies

UM CFAR SCCC 阿根廷病毒引起的艾滋病恶性肿瘤研究和培训联盟

• 批准号: 10246315
• 负责人: Omar Adrian Coso
• 金额: $ 18.26万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-20 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10246315
• 关键词: AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Affect; Anus; Area; Argentina; Argentine; Award; Basic Science; Bioinformatics; Biological; Cancer Center; Cancer Etiology; Carcinoma; Chemoprevention; Clinical; Clinical Research; Country; Data; Development; Diagnosis; Epidemiology; Epithelial; Galactose Binding Lectin; Galectin 1; Genomic approach; HIV; HIV Infections; Herpesviridae; High Prevalence; Human Herpesvirus 4; Human Herpesvirus 8; Human Papillomavirus; Human Resources; Human papillomavirus 16; Incidence; Individual; Infrastructure; Institution; Integration Host Factors; Kaposi Sarcoma; Knowledge; Latin America; Lectin; Longitudinal cohort; Malignant - descriptor; Malignant Neoplasms; Mediating; Mentors; Molecular; Molecular Epidemiology; Molecular Genetics; Oncogenic; Oncology; Oncornaviruses; PTGS2 gene; Papillomavirus; Polysaccharides; Population; Prevention; Professional Competence; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resource Development; Resource Sharing; Resources; Risk; Role; Sampling; Scientist; Signal Transduction; Training; Translational Research; Universities; Viral; Viral Cancer; Viral Epidemiology; Virus; Vulnerable Populations; Writing; c new; cancer genomics; cancer type; carcinogenesis; career; career development; genetic epidemiology; high risk; high throughput screening; immunoregulation; infection risk; instrument; low and middle-income countries; men who have sex with men; multidisciplinary; new therapeutic target; premalignant; prevent; programs; prospective; repository; social vulnerability; therapeutic target; training opportunity; transgender women; transmission process; tumorigenesis; virus related cancer

Around 80% of viral cancers occur in countries with emerging economies such as LMICs. An important subset of virally induced malignancies occurs in the context of HIV/ AIDS (AIDS associated Malignancies/ AM). Latin America have a high prevalence of AIDS-associated Malignancies caused by viruses (including HR-HPV, EBV, KSHV) which tend to disproportionally affect underprivileged and socially vulnerable populations. The current consortium addresses the need of developing research strength in AIDS associated Malignancies while developing a critical mass of independent basic, translational and clinical AIDS-malignancies researchers of Argentina. The current U54 will focus in the career development of junior scientists belonging to an existing consortium of UM CFAR with Argentina Labs through the development of mentored research focusing in the general theme and cancer type of “Basic, translational and Clinical research and training network in virally- induced AIDS-defining malignancies disproportionally affecting Argentina populations with highest risk of HIV/ AIDS”. In the case of Buenos Aires this is both the MSM population with a 11% HIV-infection incidence and the transgender women (TGW) population with an HIV-infection incidence of 37% which are at also the highest risk for infection with oncoviruses KSHV and HR-HPV, and to develop KS and anogenital carcinoma. It will further develop areas emerging from highly complementary and integrated current research of the consortium projects supported by highly tailored Career Enhancement and Shared Resources Cores that will leverage the outstanding research, human resources and infrastructure for HIV/AIDS and viral oncology research available at UM's CFAR, Sylvester Cancer Center, Argentina institutions and the powerful network of Argentine US scientists in USA associated with the consortium. Its components will include an Administrative core, a career enhancement core, a shared resource core and three projects of mentored research that will leverage and enhance the scientific and clinical capacity of the network, generating and leveraging a repository of clinical samples and longitudinal cohort that will enable to correlate clinical findings with molecular/genetic data. Aim 1: To develop research capacity in AM by developing the career of a critical mass of junior researchers in the context of shared resources and scientific networks provided by the consortium institutions. Aim 2: research on “Viral induced AIDS-defining malignancies disproportionally affecting populations in Argentina with the highest risk of HIV/ AIDS” to elucidate molecular and cellular mechanisms of oncogenesis, identify therapeutic targets, prevent cancer, facilitate diagnosis and treatment. P1: Oncogenic signaling networks in AIDS-associated viral cancers as targets of chemoprevention and treatment. P2: Molecular, viral and genetic epidemiology of virally induced AIDS-defining cancers affecting Argentina population with highest risk for HIV infection. P3: Defining the role of lectin-glycan interactions in virally induced AIDS-associated cancers.

大约 80% 的病毒性癌症发生在中低收入国家等新兴经济体国家。一个重要的子集 病毒诱发的恶性肿瘤发生在 HIV/艾滋病（艾滋病相关恶性肿瘤/AM）的背景下。拉丁 美国由病毒（包括 HR-HPV、EBV、 KSHV），这往往会对弱势群体和社会弱势群体产生不成比例的影响。目前的 联盟解决了发展艾滋病相关恶性肿瘤研究力量的需要，同时 培养一批独立的基础、转化和临床艾滋病恶性肿瘤研究人员 阿根廷。目前的 U54 将重点关注属于现有机构的初级科学家的职业发展 UM CFAR 与阿根廷实验室组成的联盟，通过开展重点研究领域的指导研究 “病毒性基础、转化和临床研究与培训网络”的一般主题和癌症类型 引起的艾滋病定义的恶性肿瘤对艾滋病毒/艾滋病风险最高的阿根廷人口造成了不成比例的影响 艾滋病”。就布宜诺斯艾利斯而言，这既是 HIV 感染率 11% 的 MSM 人群，也是 跨性别女性 (TGW) 人群的 HIV 感染率为 37%，也是最高的 感染肿瘤病毒 KSHV 和 HR-HPV 以及发生 KS 和肛门生殖器癌的风险。它将 进一步发展联盟当前研究的高度互补和综合的新兴领域 由高度定制的职业提升和共享资源核心支持的项目，将利用 艾滋病毒/艾滋病和病毒肿瘤学研究方面拥有出色的研究、人力资源和基础设施 在 UM 的 CFAR、西尔维斯特癌症中心、阿根廷机构和阿根廷美国的强大网络 美国科学家与该联盟有联系。其组成部分将包括行政核心、职业 增强核心、共享资源核心和三个指导研究项目，这些项目将利用和 增强网络的科学和临床能力，生成和利用临床数据库 样本和纵向队列能够将临床发现与分子/遗传数据相关联。 目标 1：通过发展关键数量的初级研究人员的职业生涯来发展增材制造的研究能力 联盟机构提供的共享资源和科学网络的背景。目标 2： 关于“病毒引起的艾滋病定义的恶性肿瘤对阿根廷人口的影响不成比例”的研究 艾滋病毒/艾滋病的最高风险”阐明肿瘤发生的分子和细胞机制，确定 治疗目标，预防癌症，促进诊断和治疗。 P1：致癌信号网络 与艾滋病相关的病毒性癌症作为化学预防和治疗的目标。 P2：分子、病毒和遗传 病毒诱发的艾滋病定义癌症影响阿根廷艾滋病毒高危人群的流行病学 感染。 P3：定义凝集素-聚糖相互作用在病毒诱导的艾滋病相关癌症中的作用。