UM CFAR SCCC Argentina Consortium for research and training in Virally Induced AIDS Malignancies

UM CFAR SCCC 阿根廷病毒引起的艾滋病恶性肿瘤研究和培训联盟

• 批准号: 9767729
• 负责人: Omar Adrian Coso
• 金额: $ 67.11万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-20 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9767729
• 关键词: AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Affect; Anus; Area; Argentina; Argentine; Award; Basic Science; Bioinformatics; Biological; Cancer Center; Cancer Etiology; Carcinoma; Chemoprevention; Clinical; Clinical Research; Country; Data; Development; Diagnosis; Epidemiology; Epithelial; Galactose Binding Lectin; Galectin 1; Genomic approach; HIV; HIV Infections; Herpesviridae; High Prevalence; Human Herpesvirus 4; Human Herpesvirus 8; Human Papillomavirus; Human Resources; Human papillomavirus 16; Incidence; Individual; Infrastructure; Institution; Integration Host Factors; Kaposi Sarcoma; Knowledge; Latin America; Lectin; Longitudinal cohort; Malignant - descriptor; Malignant Neoplasms; Mediating; Mentors; Molecular; Molecular Epidemiology; Molecular Genetics; Oncogenic; Oncornaviruses; PTGS2 gene; Papillomavirus; Polysaccharides; Population; Premalignant; Prevention; Professional Competence; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resource Development; Resource Sharing; Resources; Risk; Role; Sampling; Scientist; Signal Transduction; Training; Translational Research; Universities; Viral; Viral Cancer; Viral Epidemiology; Virus; Vulnerable Populations; Writing; c new; cancer genomics; cancer type; carcinogenesis; career; career development; genetic epidemiology; high risk; high throughput screening; immunoregulation; infection risk; instrument; low and middle-income countries; men who have sex with men; multidisciplinary; new therapeutic target; oncology; prevent; programs; prospective; repository; social vulnerability; therapeutic target; training opportunity; transgender women; transmission process; tumorigenesis

Around 80% of viral cancers occur in countries with emerging economies such as LMICs. An important subset of virally induced malignancies occurs in the context of HIV/ AIDS (AIDS associated Malignancies/ AM). Latin America have a high prevalence of AIDS-associated Malignancies caused by viruses (including HR-HPV, EBV, KSHV) which tend to disproportionally affect underprivileged and socially vulnerable populations. The current consortium addresses the need of developing research strength in AIDS associated Malignancies while developing a critical mass of independent basic, translational and clinical AIDS-malignancies researchers of Argentina. The current U54 will focus in the career development of junior scientists belonging to an existing consortium of UM CFAR with Argentina Labs through the development of mentored research focusing in the general theme and cancer type of “Basic, translational and Clinical research and training network in virally- induced AIDS-defining malignancies disproportionally affecting Argentina populations with highest risk of HIV/ AIDS”. In the case of Buenos Aires this is both the MSM population with a 11% HIV-infection incidence and the transgender women (TGW) population with an HIV-infection incidence of 37% which are at also the highest risk for infection with oncoviruses KSHV and HR-HPV, and to develop KS and anogenital carcinoma. It will further develop areas emerging from highly complementary and integrated current research of the consortium projects supported by highly tailored Career Enhancement and Shared Resources Cores that will leverage the outstanding research, human resources and infrastructure for HIV/AIDS and viral oncology research available at UM's CFAR, Sylvester Cancer Center, Argentina institutions and the powerful network of Argentine US scientists in USA associated with the consortium. Its components will include an Administrative core, a career enhancement core, a shared resource core and three projects of mentored research that will leverage and enhance the scientific and clinical capacity of the network, generating and leveraging a repository of clinical samples and longitudinal cohort that will enable to correlate clinical findings with molecular/genetic data. Aim 1: To develop research capacity in AM by developing the career of a critical mass of junior researchers in the context of shared resources and scientific networks provided by the consortium institutions. Aim 2: research on “Viral induced AIDS-defining malignancies disproportionally affecting populations in Argentina with the highest risk of HIV/ AIDS” to elucidate molecular and cellular mechanisms of oncogenesis, identify therapeutic targets, prevent cancer, facilitate diagnosis and treatment. P1: Oncogenic signaling networks in AIDS-associated viral cancers as targets of chemoprevention and treatment. P2: Molecular, viral and genetic epidemiology of virally induced AIDS-defining cancers affecting Argentina population with highest risk for HIV infection. P3: Defining the role of lectin-glycan interactions in virally induced AIDS-associated cancers.

大约80%的病毒性癌症发生在中低收入国家等新兴经济体国家。一个重要的子集