UM CFAR SCCC Argentina Consortium for research and training in Virally Induced AIDS Malignancies

UM CFAR SCCC 阿根廷病毒引起的艾滋病恶性肿瘤研究和培训联盟

• 批准号: 10488063
• 负责人: Omar Adrian Coso
• 金额: $ 48.84万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10488063
• 关键词: AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Affect; Anus; Area; Argentina; Argentine; Award; Basic Science; Bioinformatics; Biological; Cancer Center; Cancer Etiology; Carcinoma; Chemoprevention; Clinical; Clinical Research; Country; Data; Development; Diagnosis; Epidemiology; Epithelial; Galactose Binding Lectin; Galectin 1; Genomic approach; HIV; HIV Infections; Herpesviridae; High Prevalence; Human Herpesvirus 4; Human Herpesvirus 8; Human Papillomavirus; Human Resources; Human papillomavirus 16; Incidence; Individual; Infrastructure; Institution; Integration Host Factors; Kaposi Sarcoma; Knowledge; Latin America; Lectin; Longitudinal cohort; Malignant - descriptor; Malignant Neoplasms; Mediating; Mentors; Molecular; Molecular Epidemiology; Molecular Genetics; Oncogenic; Oncology; Oncornaviruses; PTGS2 gene; Papillomavirus; Polysaccharides; Population; Prevention; Professional Competence; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resource Development; Resource Sharing; Resources; Risk; Role; Sampling; Scientist; Signal Transduction; Training; Translational Research; Universities; Viral; Viral Cancer; Viral Epidemiology; Virus; Vulnerable Populations; Writing; cancer genomics; cancer type; carcinogenesis; career; career development; genetic epidemiology; high risk; high throughput screening; immunoregulation; infection risk; instrument; low and middle-income countries; men who have sex with men; multidisciplinary; new therapeutic target; premalignant; prevent; programs; prospective; repository; social vulnerability; therapeutic target; training opportunity; transgender women; transmission process; tumorigenesis; virus related cancer

Around 80% of viral cancers occur in countries with emerging economies such as LMICs. An important subset of virally induced malignancies occurs in the context of HIV/ AIDS (AIDS associated Malignancies/ AM). Latin America have a high prevalence of AIDS-associated Malignancies caused by viruses (including HR-HPV, EBV, KSHV) which tend to disproportionally affect underprivileged and socially vulnerable populations. The current consortium addresses the need of developing research strength in AIDS associated Malignancies while developing a critical mass of independent basic, translational and clinical AIDS-malignancies researchers of Argentina. The current U54 will focus in the career development of junior scientists belonging to an existing consortium of UM CFAR with Argentina Labs through the development of mentored research focusing in the general theme and cancer type of “Basic, translational and Clinical research and training network in virally- induced AIDS-defining malignancies disproportionally affecting Argentina populations with highest risk of HIV/ AIDS”. In the case of Buenos Aires this is both the MSM population with a 11% HIV-infection incidence and the transgender women (TGW) population with an HIV-infection incidence of 37% which are at also the highest risk for infection with oncoviruses KSHV and HR-HPV, and to develop KS and anogenital carcinoma. It will further develop areas emerging from highly complementary and integrated current research of the consortium projects supported by highly tailored Career Enhancement and Shared Resources Cores that will leverage the outstanding research, human resources and infrastructure for HIV/AIDS and viral oncology research available at UM's CFAR, Sylvester Cancer Center, Argentina institutions and the powerful network of Argentine US scientists in USA associated with the consortium. Its components will include an Administrative core, a career enhancement core, a shared resource core and three projects of mentored research that will leverage and enhance the scientific and clinical capacity of the network, generating and leveraging a repository of clinical samples and longitudinal cohort that will enable to correlate clinical findings with molecular/genetic data. Aim 1: To develop research capacity in AM by developing the career of a critical mass of junior researchers in the context of shared resources and scientific networks provided by the consortium institutions. Aim 2: research on “Viral induced AIDS-defining malignancies disproportionally affecting populations in Argentina with the highest risk of HIV/ AIDS” to elucidate molecular and cellular mechanisms of oncogenesis, identify therapeutic targets, prevent cancer, facilitate diagnosis and treatment. P1: Oncogenic signaling networks in AIDS-associated viral cancers as targets of chemoprevention and treatment. P2: Molecular, viral and genetic epidemiology of virally induced AIDS-defining cancers affecting Argentina population with highest risk for HIV infection. P3: Defining the role of lectin-glycan interactions in virally induced AIDS-associated cancers.

大约80%的病毒性癌症发生在新兴经济体国家，如中低收入国家。一个重要子集 病毒诱导的恶性肿瘤发生在HIV/ AIDS的背景下（AIDS相关的恶性肿瘤/ AM）。拉丁 在美国，由病毒（包括HR-HPV，EBV， KSHV），这往往会对贫困和社会弱势群体产生不利影响。当前 该联盟致力于发展艾滋病相关肿瘤的研究力量， 培养一批独立的基础、转化和临床艾滋病-恶性肿瘤研究人员， Argentina.目前的U 54将侧重于属于现有的初级科学家的职业发展。 UM CFAR与阿根廷实验室的联盟，通过开发指导研究，重点是 “病毒学基础、转化和临床研究和培训网络”的总主题和癌症类型- 导致艾滋病定义的恶性肿瘤，对阿根廷艾滋病毒/艾滋病高危人群造成不良影响 艾滋病”。在布宜诺斯艾利斯，这既是男男性行为者，艾滋病毒感染率为11%， 艾滋病毒感染率为37%的变性妇女人口也是最高的 感染肿瘤病毒KSHV和HR-HPV的风险，并发展KS和肛门生殖器癌。它将 进一步开发该联盟当前高度互补和综合的研究领域 由高度定制的职业提升和共享资源核心支持的项目，将利用 为艾滋病毒/艾滋病和病毒肿瘤学研究提供杰出的研究、人力资源和基础设施 在UM的CFAR，西尔维斯特癌症中心，阿根廷机构和阿根廷美国强大的网络 与该联盟有联系的美国科学家。其组成部分将包括一个行政核心，一个职业生涯， 增强核心，一个共享资源核心和三个指导研究项目， 提高网络的科学和临床能力，生成和利用临床 样本和纵向队列，这将使临床发现与分子/遗传数据相关联。 目标1：通过发展关键质量的初级研究人员的职业生涯， 合作体各机构提供的共享资源和科学网络。目标二： 关于“病毒引起的艾滋病定义的恶性肿瘤对阿根廷人口的预防性影响， 艾滋病毒/艾滋病的最高风险”，以阐明肿瘤发生的分子和细胞机制， 治疗靶点，预防癌症，方便诊断和治疗。P1：致癌信号网络 艾滋病相关的病毒性癌症作为化学预防和治疗的目标。P2：分子、病毒和遗传 影响阿根廷艾滋病毒高危人群的病毒引起的艾滋病定义癌症的流行病学 感染P3：确定凝集素-聚糖相互作用在病毒诱导的艾滋病相关癌症中的作用。

项目成果

Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells.

缺氧支持最终耗尽的 CD8 T 细胞的分化。

• DOI: 10.3389/fimmu.2021.660944
• 发表时间: 2021
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Bannoud N;Dalotto-Moreno T;Kindgard L;García PA;Blidner AG;Mariño KV;Rabinovich GA;Croci DO
• 通讯作者: Croci DO

Untangling Galectin-Mediated Circuits that Control Hypoxia-Driven Angiogenesis.

• DOI: 10.1007/978-1-0716-2055-7_34
• 发表时间: 2022-01-01
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Bannoud, Nadia;Garcia, P Alfredo;Croci, Diego O
• 通讯作者: Croci, Diego O

Autophagy in Viral Development and Progression of Cancer.

• DOI: 10.3389/fonc.2021.603224
• 发表时间: 2021
• 期刊: Frontiers in oncology
• 影响因子: 4.7
• 作者: Suares A;Medina MV;Coso O
• 通讯作者: Coso O

A clinical and molecular portrait of non-metastatic anal squamous cell carcinoma.

• DOI: 10.1016/j.tranon.2021.101084
• 发表时间: 2021-06
• 期刊: Translational oncology
• 影响因子: 5
• 作者: Iseas S;Golubicki M;Robbio J;Ruiz G;Guerra F;Mariani J;Salanova R;Cabanne A;Eleta M;Gonzalez JV;Basiletti J;Picconi MA;Masciangioli G;Carballido M;Roca E;Mendez G;Coraglio M;Abba MC
• 通讯作者: Abba MC

The universe of galectin-binding partners and their functions in health and disease.

• DOI: 10.1016/j.jbc.2023.105400
• 发表时间: 2023-12
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Troncoso, Maria F.;Elola, Maria T.;Blidner, Ada G.;Sarrias, Luciana;Espelt, Maria, V;Rabinovich, Gabriel A.
• 通讯作者: Rabinovich, Gabriel A.