Reducing risk factors for type 2 diabetes in American Indian youth: Tribal Turning Point

减少美洲印第安青年 2 型糖尿病的危险因素：部落转折点

• 批准号: 10246804
• 负责人: Dana Dabelea
• 金额: $ 54.99万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10246804
• 关键词: 10 year old; Active Learning; Address; Adult; Alaska Native; American Indians; Award; Behavior; Behavior Therapy; Behavioral; Beverages; Body mass index; Childhood; Clinical effectiveness; Collaborations; Communities; Control Groups; Counseling; Data; Diabetes prevention; Diet; Enrollment; Ethnic group; Evidence based intervention; Evidence based program; Eye; Fasting; Future; Glycosylated hemoglobin A; Goals; Health; Health behavior; Hour; Incidence; Individual; Insulin; Insulin Resistance; Intervention; Life Style Modification; Literature; Measures; Mediating; Metabolic; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Parents; Physical activity; Pilot Projects; Population; Population Intervention; Prevalence; Process; Randomized; Randomized Controlled Trials; Research Design; Research Personnel; Resources; Risk Factors; Rural; Rural Community; Safety; Schools; Site; Strenuous Exercise; Training; Translating; United States; United States Indian Health Service; Urban Community; Weight maintenance regimen; Youth; aged; base; community based participatory research; community setting; design; diabetes prevention program; diabetes risk; dietary; follow-up; fruits and vegetables; high risk; implementation efforts; implementation strategy; improved; innovation; meetings; member; motivational enhancement therapy; native youth; non-Native; patient engagement; prevent; primary caregiver; primary outcome; program dissemination; programs; racial and ethnic; secondary outcome; service providers; success; treatment effect; tv watching; waist circumference

Project Summary American Indian (Native) youth have the highest incidence and prevalence of pediatric type 2 diabetes of all racial/ethnic groups in the United States. Lifestyle modification has been shown to prevent type 2 diabetes among high-risk adults by up to 58%, including among Native populations, but similar efforts in Native youth have been largely unsuccessful. We recently developed a behavioral intervention for Native youth-parent dyads called Tribal Turning Point (TTP). In a randomized pilot study, we demonstrated feasibility of program delivery, acceptability by Native stakeholders, and significant treatment effects for multiple obesity measures. We now propose to conduct a randomized controlled trial to rigorously evaluate the effect of TTP on diabetes risk factors in 300 overweight/obese Native youth aged 7-10 years who are living in urban or rural communities served by the Indian Health Services. Within each community, youth will be randomized to the TTP program or a general health and safety control program. The multi-component TTP intervention is a youth-centered adaptation of the Diabetes Prevention Program designed to reduce diabetes risk factors by improving activity and dietary behaviors. The 12-month intervention includes 12 active learning group classes, 7 individual youth/parent motivational interviewing counseling sessions, and community-specific resource toolboxes. In this trial, we will assess the effect of TTP on anthropometric, metabolic, and behavioral risk factors for type 2 diabetes at the end of the intervention (12mo) and after 1 year of follow-up (24mo). With an eye toward widespread dissemination of the program, we will also collect qualitative data on factors related to participant engagement, program delivery, and potential for sustainability throughout the award period, which will guide future implementation efforts. The specific aims of our proposal are: 1) Evaluate the effect of TTP on anthropometric (primary: BMI; secondary: BMI z-score, waist circumference) and metabolic (primary: fasting insulin; secondary: hemoglobin A1c) diabetes risk factors at 12 and 24 months. 2) Examine the effect of TTP on health behaviors (diet, physical activity) and the extent to which improvements in health behaviors mediate the effects of TTP on diabetes risk factors. 3) Explore individual, organizational, and community-level factors related to participant engagement, program implementation, and potential for sustained delivery.

项目摘要 美国印第安人（原住民）青年儿童2型糖尿病的发病率和患病率最高 美国的种族/民族。生活方式的改变已被证明可以预防2型糖尿病 在高风险成年人中高达58%，包括土著人口，但在土著青年中也有类似的努力。 基本上都不成功。我们最近开发了一种行为干预， 部落转折点（TTP）在一项随机试点研究中，我们证明了方案的可行性， 交付，可接受的土著利益相关者，和显着的治疗效果的多种肥胖措施。 我们现在建议进行一项随机对照试验，以严格评估TTP对糖尿病的影响 300名居住在城市或农村社区的7-10岁超重/肥胖土著青年的危险因素 由印度卫生部提供服务。在每个社区内，青年将被随机分配到TTP计划或 一般健康和安全控制计划。多成分TTP干预是一种以青年为中心的 调整糖尿病预防计划，旨在通过改善活动减少糖尿病风险因素 和饮食行为。为期12个月的干预包括12个主动学习小组班，7个独立学习班， 青年/家长动机访谈咨询会议，以及社区特定资源工具箱。在这 在一项试验中，我们将评估TTP对2型糖尿病的人体测量、代谢和行为危险因素的影响。 糖尿病在干预结束时（12个月）和1年随访后（24个月）。并着眼于 为了广泛传播该计划，我们还将收集有关参与者因素的定性数据。 参与，计划交付，以及整个奖励期间的可持续发展潜力，这将指导 今后的执行工作。我们建议的具体目标是：1）评估TTP对 人体测量（主要：BMI;次要：BMI z评分、腰围）和代谢（主要：空腹 胰岛素;次要：血红蛋白A1 c）12个月和24个月时的糖尿病风险因素。2)检查TTP的效果 健康行为（饮食、体力活动）以及健康行为改善的程度 TTP对糖尿病危险因素的影响。3)探索个人、组织和社区层面的因素 与参与者参与、计划实施和持续交付的潜力有关。

项目成果

The Adaptation of a Youth Diabetes Prevention Program for Aboriginal Children in Central Australia: Community Perspectives.

• DOI: 10.3390/ijerph18179173
• 发表时间: 2021-08-31
• 期刊: International journal of environmental research and public health
• 作者: Rohit A;McCarthy L;Mack S;Silver B;Turner S;Baur LA;Canuto K;Boffa J;Dabelea D;Sauder KA;Maple-Brown L;Kirkham R
• 通讯作者: Kirkham R

Lessons on Resilient Research: Adapting the Tribal Turning Point Study to COVID-19.

• DOI: 10.5820/aian.2902.2022.155
• 发表时间: 2022
• 期刊: AMERICAN INDIAN AND ALASKA NATIVE MENTAL HEALTH RESEARCH
• 影响因子: 1.3
• 作者: Steinberg, Rachel, I;Begay, Joel A.;Begay, Paula M.;Goldtooth, Deidra L.;Nelson, Shawna Tm;Yazzie, Debra A.;Delamater, Alan M.;Hockett, Christine W.;Phimphasone-Brady, Phoutdavone;Powell, Jeffrey C.;Dabelea, Dana;Sauder, Katherine A.
• 通讯作者: Sauder, Katherine A.