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Environmental chemical exposures during pregnancy and women's cardio-metabolic health

怀孕期间的环境化学物质暴露与女性心脏代谢健康

基本信息

批准号：
10659017
负责人：
Dana Dabelea
金额：
$ 42.08万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10659017
关键词：
Address Adult Affect Air Air Pollutants Attention Behavior Behavioral Birth Body Composition Body Weight Body mass index Breast Feeding Cardiometabolic Disease Cardiovascular Diseases Characteristics Chemical Exposure Child Child Health Chronic Disease Cohort Studies Collaborations Data Data Collection Diabetes Mellitus Diet Enrollment Environment Environmental Exposure Environmental Impact Evaluation Event Exposure to Fatty acid glycerol esters Flame Retardants Funding Gestational Diabetes Glucose Health Hepatic Infant Health Joints Life Life Cycle Stages Link Longevity Longitudinal Studies Magnetic Resonance Imaging Maternal Health Measurement Medical Records Metabolic Metal exposure Metals Modeling Morbidity - disease rate Mothers National Institute of Environmental Health Sciences OGTT Obesity Organophosphates Outcome Parabens Participant Persons Phenols Plethysmography Poly-fluoroalkyl substances Population Postpartum Period Pre-Eclampsia Predisposition Pregnancy Pregnancy Outcome Pregnant Women Productivity Records Research Research Personnel Risk Risk Factors Role Serum Statistical Methods Sturnus vulgaris Time Unhealthy Diet Visit Weight Weight Gain Woman Women&apos s Group Women&apos s Health ambient air pollution cardiometabolism cardiovascular disorder risk cohort diabetes risk disorder risk environmental chemical environmental chemical exposure ethnic diversity experience fatty liver disease follow-up gestational weight gain improved lipid metabolism maternal outcome mortality novel obesity risk offspring phenotypic data phthalates pollutant post pregnancy postpartum weight pregnancy hypertension prevent public health intervention recruit residence risk mitigation urinary

项目摘要

Project Summary While much research has been devoted to exploring the impact of environmental chemical exposures during pregnancy on infant and child health, relatively little attention has focused on the potential influence of these exposures on maternal health. Recent evidence suggests that pregnancy may be a sensitive period in the life course, during which chemical exposures may have long-lasting effects on cardio-metabolic disease risk among women. Using a well-characterized existing cohort study that enrolled 1,410 pregnant women in 2009- 2014, we propose the following aims: (1) quantify the relationship between environmental exposures during pregnancy and short-term maternal health outcomes including: postpartum weight retention, reduced breastfeeding initiation and duration, and incident diabetes; (2) quantify the relationship between environmental exposures during pregnancy and long-term maternal health outcomes: body composition, weight trajectories from pregnancy through ~10 years after parturition, hepatic fat, dysglycemia and incident diabetes, and cardiovascular disease; and (3) evaluate the potential role of maternal characteristics and behaviors during pregnancy, specifically obesity and diet quality, in modifying associations between environmental chemical exposures and outcomes. Exposures during pregnancy will include serum per- and polyfluoroalkyl substances (PFAS), urinary phthalate metabolites, phenols and parabens, metals, organophosphate flame retardants, and modeled air pollutants at the maternal residential address during pregnancy. We propose to recruit 700 of the original study participants to return for a follow-up visit at ~10 years postpartum. At this visit, participants will undergo a comprehensive metabolic health evaluation including body composition via air displacement plethysmography (BOD POD), dysglycemia via oral glucose tolerance test, and hepatic fat fraction via MRI. Medical records will be abstracted to document incident diabetes and cardiovascular disease, and to reconstruct body weight trajectories. We will estimate associations between exposures during pregnancy and maternal outcomes using covariate-adjusted multivariable regression models for continuous, binary, or time-to- event data, as appropriate. Exposures will be evaluated as single pollutants and as mixtures using advanced statistical methods including Bayesian Kernel Machine Regression and Bayesian hierarchical Cox survival models. We hypothesize that maternal body mass index prior to pregnancy and diet quality during pregnancy will modify the effects of environmental chemical exposures on cardio-metabolic outcomes, such that associations will be stronger among women with obesity entering pregnancy or with poor diet quality during pregnancy. The results of this study will inform public health interventions to identify women who may be especially susceptible to the effects of environmental chemical exposures during pregnancy, and to improve the environment of pregnancy to promote the long-term health of both the offspring and the mother.

项目总结