Core 1: Biostatistics Core

项目总结 胃肠生物统计和生物信息学核心(GI-BBC)的目标是 为GI提供广泛、高质量的统计和生物信息学支持 孢子。GI-BBC的主要目的是协助GI孢子调查人员 本孢子建议的实验室和临床研究的设计、实施和分析 申请。GI-BBC将专注于协助临床和实验室 研究人员通过提供状态-将他们的临床前研究转化为临床研究- 通过统计咨询和分析进行最先进的实验设计和分析 在临床的方法学、可行性、分析和报告方面进行协作 和实验室研究。此外，GI-BBC将作为所有人的持续资源 GI-孢子调查员。核心将由Sugar博士、Scharpf博士和Dr Scharpf博士领导。 雷切尔·卡钦将担任联合调查员。这些GI-BBC的教职员工 专业领域互补：苏格博士擅长生物统计学，擅长翻译 和临床研究的设计和分析，Scharpf博士在高通量分析中 基因组分析，卡钦博士在计算遗传学。Amanda Blackford女士，A 癌症中心的生物统计学家，将协助Sugar和Scharpf博士进行统计 分析。David McKean是一位硕士级别的生物信息学专家，他将协助Dr。 沙尔夫。GI-BBC核心内部统计需求的集中将提供孢子 调查人员可以接触到一支拥有必要技能的统计学家团队 以具有成本效益的方式满足孢子的当前和未来目标。此外, 它将促进孢子项目之间的交流，帮助研究成果的翻译 将这一发现转化为临床环境。

PROJECT SUMMARY The goal of the GastroIntestinal Biostatistics and Bioinformatics Core (GI-BBC) is to provide wide-ranging, high-quality statistical and bioinformatics support to the GI SPORE. The primary aim of the GI-BBC is to assist GI SPORE investigators in the design, conduct and analysis of laboratory and clinical studies proposed in this SPORE application. The GI-BBC will focus its efforts on assisting both the clinical and laboratory investigators in translating their pre-clinic studies into clinical studies by providing state- of-the-art experimental designs and analyses through statistical consultation and in collaboration with respect to methodology, feasibility, analysis, and reporting of clinical and laboratory studies. In addition, the GI-BBC will serve as an ongoing resource for all GI-SPORE investigators. The Core will be led by Dr. Sugar and Dr. Scharpf and Dr. Rachel Karchin will act as a co-investigator. These GI-BBC faculty members have complementary areas of expertise: Dr. Sugar in biostatistics specializing in translation and clinical study design and analysis, Dr. Scharpf in the analysis of high-throughput genomic assays, Dr. Karchin in computational genetics. Ms. Amanda Blackford, a biostatistician in the Cancer Center, will assist Drs. Sugar and Scharpf in statistical analyses. David McKean, a Master's level bioinformatics specialist will assist Dr. Scharpf. Centralization of statistical needs within the GI-BBC core will provide SPORE investigators with open access to a team of statisticians with the skill set necessary to meet the current and future goals of the SPORE in a cost-effective manner. In addition, it will facilitate communication across SPORE projects, aiding the translation of research findings into the clinical setting.