Model-guided design of next-generation bacterial therapeutics to treat cardiovascular disease

模型引导设计下一代治疗心血管疾病的细菌疗法

基本信息

  • 批准号:
    10249177
  • 负责人:
  • 金额:
    $ 66.72万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-01 至 2024-05-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT It is becoming increasingly evident that the composition and metabolites produced by the human gut microbiome influence the progression of cardiovascular diseases. While we are continuing to discover important associations between the gut microbiome and human physiology and diseases, we lack the tools and methodology to precisely manipulate gut microbiota to benefit human health. We propose to develop computational models and optimization frameworks to predict community dynamics and functions and design interventions to shift the gut microbiome to desired states. We will design novel bacterial therapeutics that operate autonomously in the mammalian gastrointestinal tract to steer the microbiome towards healthy states. These next-generation bacterial therapeutics will sense important gut microbiome metabolites, process information, and deliver species- specific antimicrobial proteins to reshape the dynamics and functions of this ecosystem. The performance of these bacterial therapeutics will be characterized in vitro using synthetic human gut microbiome communities and in gnotobiotic mouse models of cardiovascular disease. Model-guided microbiome engineering has the potential to transform human medicine and is becoming increasingly important as scientists continue to discover connections between the microbiome and human health and disease.
项目摘要/摘要 越来越明显的是,人类肠道微生物组产生的成分和代谢产物 影响心血管疾病的进展。当我们继续发现 肠道微生物组与人体生理和疾病之间的联系,我们缺乏工具和方法, 精确地操纵肠道微生物群以有益于人类健康。我们建议开发计算模型, 优化框架来预测社区动态和功能,并设计干预措施来改变肠道 微生物群达到所需状态。我们将设计新的细菌治疗方法, 哺乳动物的胃肠道,以引导微生物组向健康状态。这些下一代 细菌疗法将感知重要的肠道微生物代谢物,处理信息,并提供物种- 特定的抗微生物蛋白来重塑这个生态系统的动态和功能。的性能 这些细菌治疗剂将使用合成的人类肠道微生物群落在体外表征 以及在心血管疾病的无菌小鼠模型中。模型引导的微生物组工程具有 随着科学家们不断发现, 微生物组与人类健康和疾病之间的联系。

项目成果

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Federico E Rey其他文献

Federico E Rey的其他文献

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{{ truncateString('Federico E Rey', 18)}}的其他基金

Model-guided design of next-generation bacterial therapeutics to treat cardiovascular disease
模型引导设计下一代治疗心血管疾病的细菌疗法
  • 批准号:
    10044931
  • 财政年份:
    2020
  • 资助金额:
    $ 66.72万
  • 项目类别:
Model-guided design of next-generation bacterial therapeutics to treat cardiovascular disease
模型引导设计下一代治疗心血管疾病的细菌疗法
  • 批准号:
    10453661
  • 财政年份:
    2020
  • 资助金额:
    $ 66.72万
  • 项目类别:
Administrative Supplement: Model-guided design of next-generation bacterial therapeutics to treat cardiovascular disease
行政补充:治疗心血管疾病的下一代细菌疗法的模型引导设计
  • 批准号:
    10838889
  • 财政年份:
    2020
  • 资助金额:
    $ 66.72万
  • 项目类别:
Model-guided design of next-generation bacterial therapeutics to treat cardiovascular disease
模型引导设计下一代治疗心血管疾病的细菌疗法
  • 批准号:
    10624465
  • 财政年份:
    2020
  • 资助金额:
    $ 66.72万
  • 项目类别:
Collaborative Cross of the Microbiome and Metabolic Disease
微生物组与代谢疾病的协作交叉
  • 批准号:
    9038121
  • 财政年份:
    2015
  • 资助金额:
    $ 66.72万
  • 项目类别:
Collaborative Cross of the Microbiome and Metabolic Disease
微生物组与代谢疾病的协作交叉
  • 批准号:
    9545554
  • 财政年份:
    2015
  • 资助金额:
    $ 66.72万
  • 项目类别:

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