Consortium on Translational Research in Early Detection of Liver Cancer: Data Management and Coordinating Center (DMCC)
Consortium on Translational Research in Early Detection of Liver Cancer: Data Management and Coordinating Center (DMCC)
批准号:
10249162
负责人:
Ziding Feng
金额:
$39.0万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-17 至 2022-03-31
关键词:
BioinformaticsBiological MarkersBiological Specimen BanksBiological Specimen databaseBiometryCancer BurdenCancer DetectionCenter for Translational Science ActivitiesCirrhosisClinicalClinical DataCollaborationsCollectionCommon Data ElementCommunicationComputer AnalysisConsultationsDataData CollectionData SetDatabasesDisciplineEarly DiagnosisEnsureEvaluationEvaluation StudiesGuidelinesImageInformation TechnologyInfrastructureLogisticsMalignant neoplasm of liverManagement Information SystemsManualsMedicineMonitorPatientsPhaseProspective StudiesProtocols documentationPublic HealthRandomizedResearchResearch DesignResearch PersonnelResearch SupportRetrospective StudiesSamplingScientistScreening for Hepatocellular CancerScreening for cancerSecureSpecimenStatistical Data InterpretationStatistical MethodsSystemTestingTranslational ResearchUnited StatesUniversity of Texas M D Anderson Cancer CenterWorkanticancer researchbiomarker developmentbiomarker evaluationcancer biomarkerscohortcollegecomputerized data processingdata managementdata repositorydata sharingexperienceimprovedinformatics toolinnovationinstrumentmeetingsoperationphase 3 studyprotocol developmentresearch studyrisk stratificationsuccesssymposiumvalidation studiesweb site
中文摘要
项目摘要
翻译研究联合体在肝脏早期检测中取得成功的关键
癌症(联盟)在于多学科科学家之间的良好沟通;高效
有前景的生物标志物的评估和优先顺序;以及严格的验证研究,以
展示它们在改善对肝癌的监测和早期发现方面的临床效用
以及对肝硬变患者患肝癌的风险进行分层。拟议方案的总体目标
数据管理和协调中心(DMCC)将(I)加强沟通和
财团调查人员之间的合作;(2)协调财团合作研究
并提供统计支助;(3)开发和维护一个综合研究数据库和
用于财团研究的生物信息库数据库;以及(Iv)帮助财团开发和
实施生物标记物翻译路径的策略。
在财团指导委员会的指导下,DMCC将1)实施网络
通过提供支持,协调和促进科学研究人员之间的合作
财团会议,开发和维护财团安全网站和列表服务器,以及
制作和维护所有财团文件;2)支持财团协作
通过与联合会调查人员在研究设计、方案开发、数据方面的合作进行研究
表格和研究手册;协调和监测研究;跟踪标本共享,
盲法和随机化;以及执行QA/QC和研究评估;3)开发和
维护财团集成信息管理系统,提供在线、端到端的
终端数据管理解决方案,包括研究通信、法规遵从性、远程
患者注册、临床数据捕获、生物样品管理、成像数据
存储库、文档管理和信息工具;以及4)使用阶段性生物标志物
开发指南和探索性研究设计标准,以帮助财团制定
路线图和战略,并确保财团协作阶段2的严谨和高效
以及第三阶段研究,使用现有的和新收集的来自不同队列的样本。
英文摘要
Project Summary
The key for the success of the Consortium on Translational Research in Early Detection of Liver
Cancer (Consortium) lies in good communication among scientists in multiple disciplines; efficient
evaluation and prioritization of promising biomarkers; and rigorous validation studies to
demonstrate their clinical utilities in improving the surveillance and early detection of liver cancer
and stratifying the risk of liver cancer in patients with cirrhosis. The overall aims of the proposed
Data Management and Coordinating Center (DMCC) are to (i) enhance communication and
collaboration among Consortium investigators; (ii) coordinate Consortium collaborative research
and provide statistical support; (iii) develop and maintain an integrated research database and
biorepository database for Consortium studies; and (iv) help the Consortium develop and
implement strategies for biomarker translational paths.
Under the direction of the Consortium Steering Committee, the DMCC will 1) perform network
coordination and promote collaborations among scientific investigators by providing support for
Consortium meetings, developing and maintaining Consortium secure websites and listservs, and
producing and maintaining all Consortium documents; 2) support Consortium collaborative
studies by working with Consortium investigators on study design, protocol development, data
forms, and study manuals; coordinating and monitoring studies; tracking specimen sharing,
blinding, and randomization; and performing QA/QC and study evaluation; 3) develop and
maintain a Consortium integrated information management system that provides online, end-to-
end data management solutions, including study communications, regulatory compliance, remote
patient registration, clinical data capture, biospecimen sample management, imaging data
repository, document management, and informatic tools; and 4) use the phased biomarker
development guidelines and PRoBE study design standards to help the Consortium develop a
roadmap and strategies and ensure rigor and efficiency of the Consortium collaborative phase-2
and phase-3 studies using existing and newly collected specimens from heterogeneous cohorts.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Biostatistics Core
-
批准号:10706325
-
项目类别:
-
资助金额:$9.42万
-
财政年份:2021
-
负责人:Ziding Feng
-
依托单位:
Biostatistics Core
-
批准号:10286762
-
项目类别:
-
资助金额:$11.01万
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财政年份:2021
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负责人:Ziding Feng
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依托单位:
Biostatistics Core
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批准号:10482374
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项目类别:
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资助金额:$9.43万
-
财政年份:2021
-
负责人:Ziding Feng
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依托单位:
Consortium on Translational Research in Early Detection of Liver Cancer: Data Management and Coordinating Center (DMCC)
-
批准号:10601411
-
项目类别:
-
资助金额:$25.43万
-
财政年份:2018
-
负责人:Ziding Feng
-
依托单位:
Consortium on Translational Research in Early Detection of Liver Cancer: Data Management and Coordinating Center (DMCC)
-
批准号:10006517
-
项目类别:
-
资助金额:$55.37万
-
财政年份:2018
-
负责人:Ziding Feng
-
依托单位:
Consortium on Translational Research in Early Detection of Liver Cancer:Data Management and Coordinating Center (DMCC)
-
批准号:10734730
-
项目类别:
-
资助金额:$73.8万
-
财政年份:2018
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负责人:Ziding Feng
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依托单位:
Incorporating Biomarkers to Improve Lung Cancer Risk Prediction
-
批准号:9020598
-
项目类别:
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资助金额:$69.23万
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财政年份:2016
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负责人:Ziding Feng
-
依托单位:
Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer: Coordinating and Data Management Center (CSCPDPC-CDMC)
-
批准号:9352326
-
项目类别:
-
资助金额:$155.2万
-
财政年份:2015
-
负责人:Ziding Feng
-
依托单位:
Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer: Coordinating and Data Management Center (CSCPDPC-CDMC)
-
批准号:9336208
-
项目类别:
-
资助金额:$100.0万
-
财政年份:2015
-
负责人:Ziding Feng
-
依托单位:
Statistical methods for Biomarker Discovery, Evaluation, and Validation
-
批准号:7152314
-
项目类别:
-
资助金额:$6.78万
-
财政年份:2006
-
负责人:Ziding Feng
-
依托单位:
EDRN--DATA MANAGEMENT AND COORDINATING CENTER
-
批准号:6740862
-
项目类别:
-
资助金额:$176.9万
-
财政年份:2000
-
负责人:Ziding Feng
-
依托单位:
Early Detection Research Network: Data Management and Coordinating Center
-
批准号:8130940
-
项目类别:
-
资助金额:$189.22万
-
财政年份:2000
-
负责人:Ziding Feng
-
依托单位:
Early Detection Research Network: Data Management and Coordinating Center
-
批准号:8293417
-
项目类别:
-
资助金额:$183.73万
-
财政年份:2000
-
负责人:Ziding Feng
-
依托单位:
Early Detection Research Network: Data Management and Coordinating Center
-
批准号:8504969
-
项目类别:
-
资助金额:$167.89万
-
财政年份:2000
-
负责人:Ziding Feng
-
依托单位:
EDRN--DATA MANAGEMENT AND COORDINATING CENTER
-
批准号:6789770
-
项目类别:
-
资助金额:$27.89万
-
财政年份:2000
-
负责人:Ziding Feng
-
依托单位:
EDRN--DATA MANAGEMENT AND COORDINATING CENTER
-
批准号:6633738
-
项目类别:
-
资助金额:$90.47万
-
财政年份:2000
-
负责人:Ziding Feng
-
依托单位:
EDRN--DATA MANAGEMENT AND COORDINATING CENTER
-
批准号:6789769
-
项目类别:
-
资助金额:$23.64万
-
财政年份:2000
-
负责人:Ziding Feng
-
依托单位:
EDRN:Data Management and Coordinating Center
-
批准号:8037425
-
项目类别:
-
资助金额:$66.7万
-
财政年份:2000
-
负责人:Ziding Feng
-
依托单位:
STATISTICAL METHODS FOR COMMUNITY INTERVENTION TRIALS
-
批准号:6200259
-
项目类别:
-
资助金额:$23.84万
-
财政年份:2000
-
负责人:Ziding Feng
-
依托单位:
STATISTICAL METHODS FOR COMMUNITY INTERVENTION TRIALS
-
批准号:6514256
-
项目类别:
-
资助金额:$23.37万
-
财政年份:2000
-
负责人:Ziding Feng
-
依托单位:
海外基金