Statistical methods for Biomarker Discovery, Evaluation, and Validation

生物标志物发现、评估和验证的统计方法

基本信息

  • 批准号:
    7152314
  • 负责人:
  • 金额:
    $ 6.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-07-01 至 2011-06-30
  • 项目状态:
    已结题

项目摘要

This project will address methodology development needs that are important for biomarker discovery. evaluation, and validation. These include: (i) analysis of structure and variance in functional data (spectra and/or images) for biomarker discovery; (ii) evaluating the predictive values of prognostic biomarkers; and (iii) development of group sequential study designs and analysis methods for biomarker validation. First, we focus on decomposing complex functional data via wavelet and/or differential analysis. This analysis of coherent structure and variation allows for a refined focus on features leading to discrimination between disease classes. Second, for evaluating the predictive values of prognostic biomarkers, we propose a simple yet clinically relevant measure, positive predictive value (PPV) curve for survival data. Estimating and inference procedures of the PPV curves, the use of PPV curves for comparing predictive values of biomarkers, selecting models, and combining biomarkers will be studied. A third aim is to develop group sequential study designs and analysis "methods for biomarker validation studies. Focus is on developing group sequential testing and estimation methods for biomarker validation studies but we will also investigate group sequential testing and estimation methods for prospective screening studies. The biomarker discovery, evaluation, and validation studies in the Early Detection Research Network (EDRN) provide the primary motivating settings for the proposed research.
该项目将解决对生物标志物发现非常重要的方法论开发需求。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Ziding Feng其他文献

Ziding Feng的其他文献

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{{ truncateString('Ziding Feng', 18)}}的其他基金

Biostatistics Core
生物统计学核心
  • 批准号:
    10706325
  • 财政年份:
    2021
  • 资助金额:
    $ 6.78万
  • 项目类别:
Biostatistics Core
生物统计学核心
  • 批准号:
    10286762
  • 财政年份:
    2021
  • 资助金额:
    $ 6.78万
  • 项目类别:
Biostatistics Core
生物统计学核心
  • 批准号:
    10482374
  • 财政年份:
    2021
  • 资助金额:
    $ 6.78万
  • 项目类别:
Consortium on Translational Research in Early Detection of Liver Cancer: Data Management and Coordinating Center (DMCC)
肝癌早期检测转化研究联盟:数据管理和协调中心 (DMCC)
  • 批准号:
    10601411
  • 财政年份:
    2018
  • 资助金额:
    $ 6.78万
  • 项目类别:
Consortium on Translational Research in Early Detection of Liver Cancer: Data Management and Coordinating Center (DMCC)
肝癌早期检测转化研究联盟:数据管理和协调中心 (DMCC)
  • 批准号:
    10006517
  • 财政年份:
    2018
  • 资助金额:
    $ 6.78万
  • 项目类别:
Consortium on Translational Research in Early Detection of Liver Cancer: Data Management and Coordinating Center (DMCC)
肝癌早期检测转化研究联盟:数据管理和协调中心 (DMCC)
  • 批准号:
    10249162
  • 财政年份:
    2018
  • 资助金额:
    $ 6.78万
  • 项目类别:
Consortium on Translational Research in Early Detection of Liver Cancer:Data Management and Coordinating Center (DMCC)
肝癌早期检测转化研究联盟:数据管理和协调中心(DMCC)
  • 批准号:
    10734730
  • 财政年份:
    2018
  • 资助金额:
    $ 6.78万
  • 项目类别:
Incorporating Biomarkers to Improve Lung Cancer Risk Prediction
结合生物标志物改善肺癌风险预测
  • 批准号:
    9020598
  • 财政年份:
    2016
  • 资助金额:
    $ 6.78万
  • 项目类别:
Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer: Coordinating and Data Management Center (CSCPDPC-CDMC)
慢性胰腺炎、糖尿病和胰腺癌研究联盟:协调和数据管理中心 (CSCPDPC-CDMC)
  • 批准号:
    9352326
  • 财政年份:
    2015
  • 资助金额:
    $ 6.78万
  • 项目类别:
Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer: Coordinating and Data Management Center (CSCPDPC-CDMC)
慢性胰腺炎、糖尿病和胰腺癌研究联盟:协调和数据管理中心 (CSCPDPC-CDMC)
  • 批准号:
    9336208
  • 财政年份:
    2015
  • 资助金额:
    $ 6.78万
  • 项目类别:

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