Novel Characterization and Detection Techniques for Acute Myocardial Ischemia

急性心肌缺血的新特征和检测技术

• 批准号: 10249962
• 负责人: Brian Zenger
• 金额: $ 3.4万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10249962
• 关键词: 3-Dimensional; Accident and Emergency department; Acute; Animal Model; Body Surface; Cardiac; Cardiomyopathies; Chest Pain; Clinical; Clinical Research; Computer Models; Computer Simulation; Coronary; Coronary Arteriosclerosis; Coronary artery; Data; Data Set; Detection; Development; Diagnostic; Dissection; Dobutamine; Electrocardiogram; Emergency department visit; Ensure; Environment; Evaluation; Exercise; Experimental Animal Model; Experimental Models; Exposure to; Formulation; Goals; Heart; Heart Diseases; Hospital Departments; Image; Imaging Techniques; Infusion procedures; Ischemia; Lead; Location; Measurement; Measures; Mentors; Methods; Microvascular Dysfunction; Monitor; Myocardial; Myocardial Ischemia; Myocardial perfusion; Myocardial tissue; Myocardium; Non-Invasive Cancer Detection; Painless; Patients; Performance; Pharmacology; Physicians; Preparation; Procedures; Research; Resolution; Risk; Scientist; Sensitivity and Specificity; Source; Stress; Stress Tests; Stress cardiomyopathy; Surface; Techniques; Testing; Therapeutic; Tissues; Translating; Ultrasonography; Vascular blood supply; Visit; base; bioelectricity; clinical Diagnosis; common symptom; detection method; detection platform; electrical potential; experience; experimental study; imaging approach; improved; ischemic cardiomyopathy; models and simulation; novel; response; success

2 Abstract The most common reason for a patient to visit the emergency department is chest pain caused by myocar- dial ischemia. Myocardial ischemia develops from inadequate perfusion of myocardial tissue and indicates the presence of surprising range of conditions, including coronary artery disease, coronary microvascular dysfunc- tion, Takotsubo cardiomyopathy, and coronary artery dissection, and other potentially fatal cardiac diseases. Current noninvasive tests to detect ischemia may be limited by an incomplete understanding of the mecha- nisms used to induce the stress (exercise or pharmacological agents) or the limited diagnostic data acquired to visualize ischemia (12-lead electrocardiogram or ultrasound). These limitations increase the risk for failed detection of deadly cardiac diseases and explain the unsatisfactory accuracy of current diagnostic and monitor- ing approaches. The goal of this project is to leverage recent experimental findings and breakthroughs about the onset and progression of ischemia as the basis for a comprehensive re-evaluation of acute myocardial is- chemia. We will develop and use experimental models and computer simulations to devise better techniques to detect acute myocardial ischemia and localize it within the ventricles. We will build on our experience with our novel large-animal experimental models of ischemia and electrocardiographic imaging (ECGI) techniques to measure and characterize the electrical changes that arise during acute myocardial ischemia created from various types of ischemic stress. We will use these measurements to characterize different types of cardiac stress and implement novel ECGI techniques to detect and localize ischemic sources within the heart.

2摘要 患者去急诊科就诊的最常见原因是肌瘤引起的胸痛- 拨打缺血。心肌缺血是由心肌组织灌流不足引起的，提示 一系列令人惊讶的疾病的存在，包括冠状动脉疾病，冠状动脉微血管功能障碍- 心脏病、武断心肌病、冠状动脉夹层，以及其他可能致命的心脏病。 目前用于检测缺血的非侵入性测试可能受到对机制的不完全理解的限制。 用来引起压力(运动或药物)或获得的有限诊断数据的神经系统 以可视化缺血(12导联心电图或超声)。这些限制增加了失败的风险 检测致命的心脏病，并解释当前诊断和监测的准确性不令人满意- ING接近了。该项目的目标是利用最新的试验性fi结果和突破 作为全面重新评估急性心肌的基础的缺血的发生和发展是- 丘米亚。我们将开发和使用实验模型和计算机模拟来设计更好的技术 检测急性心肌缺血并将其定位在脑室内。我们将以我们的经验为基础 我们新的大动物缺血实验模型和心电成像(ECGI)技术 测量和描述在急性心肌缺血期间引起的电变化 各种类型的缺血应激。我们将使用这些测量来描述不同类型的心脏 强调并实施新的ECGI技术以检测和定位心脏内的缺血源。