Novel Characterization and Detection Techniques for Acute Myocardial Ischemia

急性心肌缺血的新特征和检测技术

• 批准号: 10444979
• 负责人: Brian Zenger
• 金额: $ 4.96万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10444979
• 关键词: 3-Dimensional; Accident and Emergency department; Acute; Animal Model; Body Surface; Cardiac; Cardiomyopathies; Chest Pain; Clinical; Clinical Research; Computer Models; Computer Simulation; Coronary; Coronary Arteriosclerosis; Coronary artery; Data; Data Set; Detection; Development; Diagnostic; Dissection; Dobutamine; Electrocardiogram; Emergency department visit; Ensure; Environment; Evaluation; Exercise; Experimental Animal Model; Experimental Models; Exposure to; Formulation; Goals; Heart; Heart Diseases; Hospital Departments; Image; Imaging Techniques; Infusion procedures; Ischemia; Lead; Location; Measurement; Measures; Mentors; Methods; Microvascular Dysfunction; Monitor; Myocardial; Myocardial Ischemia; Myocardial perfusion; Myocardial tissue; Myocardium; Non-Invasive Cancer Detection; Painless; Patients; Performance; Pharmacology; Physicians; Preparation; Procedures; Research; Resolution; Risk; Scientist; Sensitivity and Specificity; Source; Stress; Stress Tests; Stress cardiomyopathy; Surface; Techniques; Testing; Therapeutic; Tissues; Translating; Vascular blood supply; Visit; base; bioelectricity; clinical diagnosis; common symptom; detection method; detection platform; electrical potential; experience; experimental study; imaging approach; improved; ischemic cardiomyopathy; models and simulation; novel; response; success; ultrasound

2 Abstract The most common reason for a patient to visit the emergency department is chest pain caused by myocar- dial ischemia. Myocardial ischemia develops from inadequate perfusion of myocardial tissue and indicates the presence of surprising range of conditions, including coronary artery disease, coronary microvascular dysfunc- tion, Takotsubo cardiomyopathy, and coronary artery dissection, and other potentially fatal cardiac diseases. Current noninvasive tests to detect ischemia may be limited by an incomplete understanding of the mecha- nisms used to induce the stress (exercise or pharmacological agents) or the limited diagnostic data acquired to visualize ischemia (12-lead electrocardiogram or ultrasound). These limitations increase the risk for failed detection of deadly cardiac diseases and explain the unsatisfactory accuracy of current diagnostic and monitor- ing approaches. The goal of this project is to leverage recent experimental findings and breakthroughs about the onset and progression of ischemia as the basis for a comprehensive re-evaluation of acute myocardial is- chemia. We will develop and use experimental models and computer simulations to devise better techniques to detect acute myocardial ischemia and localize it within the ventricles. We will build on our experience with our novel large-animal experimental models of ischemia and electrocardiographic imaging (ECGI) techniques to measure and characterize the electrical changes that arise during acute myocardial ischemia created from various types of ischemic stress. We will use these measurements to characterize different types of cardiac stress and implement novel ECGI techniques to detect and localize ischemic sources within the heart.

2抽象

项目成果

Estimation and Validation of Cardiac Conduction Velocity and Wavefront Reconstruction Using Epicardial and Volumetric Data.

• DOI: 10.1109/tbme.2021.3069792
• 发表时间: 2021-11
• 期刊: IEEE transactions on bio-medical engineering

Effect of Myocardial Fiber Direction on Epicardial Activation Patterns.

• DOI: 10.22489/cinc.2020.399
• 发表时间: 2020-09
• 期刊: Computing in cardiology
• 作者: Rupp LC;Good WW;Bergquist JA;Zenger B;Gillette K;Plank G;MacLeod RS
• 通讯作者: MacLeod RS

The electrocardiographic forward problem: A benchmark study.

• DOI: 10.1016/j.compbiomed.2021.104476
• 发表时间: 2021-07
• 期刊: Computers in biology and medicine
• 影响因子: 7.7
• 作者: Bergquist JA;Good WW;Zenger B;Tate JD;Rupp LC;MacLeod RS
• 通讯作者: MacLeod RS

Myocardial Ischemia Detection Using Body Surface Potential Mappings and Machine Learning.

• DOI: 10.23919/cinc53138.2021.9662808
• 发表时间: 2021-09
• 期刊: Computing in cardiology

Combining endocardial mapping and electrocardiographic imaging (ECGI) for improving PVC localization: A feasibility study.

• DOI: 10.1016/j.jelectrocard.2021.08.013
• 发表时间: 2021-11
• 期刊: JOURNAL OF ELECTROCARDIOLOGY
• 影响因子: 1.3
• 作者: Good, Wilson W.;Zenger, Brian;Bergquist, Jake A.;Rupp, Lindsay C.;Gillette, Karli;Angel, Nathan;Chou, Derrick;Plank, Gernot;MacLeod, Rob S.
• 通讯作者: MacLeod, Rob S.