Integrated Molecular, Cellular, and Imaging Characterization of Screen-Detected Lung Cancer

屏幕检测肺癌的分子、细胞和影像学综合表征

• 批准号: 10253429
• 负责人: DENISE R. ABERLE
• 金额: $ 62.49万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-16 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10253429
• 关键词: Academic Medical Centers; Aggressive Clinical Course; Aggressive behavior; Archives; Biological; Biological Markers; Biological Response Modifiers; Biopsy; Boston; California; Caring; Cells; Characteristics; Clinical; Clinical Data; Clinical Management; Collection; Data; Development; Discrimination; Disease; Effectiveness; Equilibrium; Excision; Expression Profiling; Funding; Gene Expression; Gene Expression Profile; Goals; Heterogeneity; Image; Immune; Indolent; Inflammation Mediators; Investigation; Laboratories; Lesion; Los Angeles; Lung; Malignant Neoplasms; Malignant neoplasm of lung; Measures; Molecular; Molecular Analysis; Mutation; Nodule; Outcome; Pathogenesis; Pathway interactions; Patients; Phenotype; Precision therapeutics; Prognostic Marker; Public Health; Sample Size; Semantics; Somatic Mutation; Specimen; Systems Analysis; Tissue Banks; Tissues; Translating; Tumor Tissue; Universities; Ursidae Family; Woman; base; biobank; cancer risk; cellular imaging; clinical decision-making; cohort; design; driver mutation; exome sequencing; insight; low-dose spiral CT; lung cancer screening; mRNA sequencing; men; mortality; multidisciplinary; new therapeutic target; personalized management; prospective; public health relevance; quantitative imaging; screening; screening policy; translational research program; tumor; tumor microenvironment

 DESCRIPTION (provided by applicant): The University of California at Los Angeles - Boston University Molecular Characterization Laboratory (UCLA- BU MCL) is a multidisciplinary, translational research program designed to enhance our understanding of the molecular, cellular and imaging features distinguishing indolent from aggressive lung cancers in screen- detected and non-screen-detected clinical settings. The National Lung Screening Trial (NLST) has provided compelling evidence of the efficacy of lung cancer screening using low-dose helical computed tomography (LDCT) to reduce lung cancer mortality. The benefits of screening, however, must be reconciled with its potential harms, including high false positive rates and the potential for overdiagnosis. Our broad goal is to distinguish indolent from aggressive lesions by interrogating the molecular, microenvironment and imaging features that are associated with clinical outcomes. This global approach brings all aspects of these investigations to bear on our understanding of the molecular pathogenesis of early stage lung cancer. These results will be translated to the clinical management of screen-detected lung cancer. Understanding the factors underlying tumor indolence or aggression that result in heterogeneous clinical outcomes will facilitate clinical decision making in the context of lung cancer screening, increase screening effectiveness and ultimately drive care pathways. We hypothesize that the pathways underlying heterogeneity in screen-detected lung cancers will be revealed by analysis of molecular (whole exome and mRNA sequencing), microenvironment (immune and inflammatory mediators) and imaging characteristics (semantic and quantitative features) of screen- detected lesions. The specific aims are: Aim 1: Identify molecular, cellular and imaging profiles that distinguish screen-detected from non-screen- detected lung cancers. Aim 2: Identify molecular, cellular and imaging profiles that distinguish screen-detected lung cancers with indolent versus aggressive clinical courses from the NLST. Aim 3: Confirm and refine molecular, cellular and imaging profiles that distinguish screen-detected lung cancers with indolent versus aggressive clinical courses from a prospectively collected screening cohort. Cases will derive from the NLST biorepository, DECAMP cohorts and a University of California (UC) state-wide initiative involving the five UC academic medical centers that are establishing a common screening policy and platform that involves the collection and archiving of clinical, imaging, and tissue specimens.