Inositol Signalling

肌醇信号传导

基本信息

批准号：
10253781
负责人：
STEPHEN B SHEARS
金额：
$ 251.05万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10253781
关键词：
2019-nCoV 3-Dimensional Area Bacteria Binding Proteins Binding Sites Biochemistry Biological Biological Products COVID-19 Carbohydrates Carbon Cell physiology Cells Characteristics Charge Confined Spaces Contracts Diphosphates Disease Electrostatics Environment Event Flow Cytometry Fluorescence Resonance Energy Transfer Head Health High Pressure Liquid Chromatography Human Hydrogen Bonding Individual Inflammation Inositol Inositol Phosphates InsP5 Intervention Laboratories Ligands Metabolic Metabolism Microscopy Molecular Molecular Biology Morphologic artifacts Muscle Contraction Nature Normal Cell Nutrient Organism Pattern Recognition Periodicity Physiological Polyphosphates Process Property Proteins Research SARS coronavirus Second Messenger Systems Severe Acute Respiratory Syndrome Signal Pathway Signal Transduction Specificity Stimulus Stress Surface Plasmon Resonance System Tail Techniques Toxic Environmental Substances Toxin Translating Virus Virus Diseases base extracellular fighting human coronavirus improved inorganic phosphate inositol heptakisphosphate interdisciplinary approach ionic bond neurotransmitter release novel novel coronavirus nutrient deprivation operation pathogen protein protein interaction recruit response sensor structural biology uptake

项目摘要

An extracellular stimulus evokes a specific response from its target cell - for example, it may command the release or uptake of nutrient, promote neurotransmitter release, or initiate muscle contraction. The information inherent in the stimulus is frequently translated into a format that can then be conveyed by intracellular emissaries: the intracellular levels and hence the activities of these "second messengers" are regulated according to the strength and duration of the original stimulus. This process - signal transduction - is fundamental to how an organism responds and adapts to changes in the environment. Unfortunately, there are many ways it can be disrupted in disease states and by environmental toxins. The adequate treatment of such disturbances requires us to have an understanding of the precise molecular mechanisms that are involved. We study the physiological actions of the inositol polyphosphate second messengers, particularly metabolites of InsP6. The latter is a precursor for other important derivatives: the "pyrophosphorylated" polyphosphates. We are exploring the significance of these novel metabolites, and the information uncovered to date strongly suggests they are "high-energy" molecules that act as sensors of specific environmental stress stimulii, including nutrient deprivation, metabolic inflammation and viral infection. This project involves research on human coronavirus, novel coronavirus, COVID-19, Severe Acute Respiratory Syndrome coronavirus disease, SARS coronavirus, SARS-coronavirus-2, SARS-cov-2, SARS-cov2, SARS-related coronavirus 2, Severe acute respiratory syndrome coronavirus 2, SARS-Associated Coronavirus, SARS-cov, or SARS-Related Coronavirus.

细胞外刺激会引起其靶细胞的特定反应 - 例如，它可以释放或摄取营养，促进神经递质释放或启动肌肉收缩。刺激中固有的信息经常被翻译成一种格式，然后可以通过细胞内使者传达：细胞内级别，因此根据原始刺激的强度和持续时间对这些“第二使者”的活性进行调节。这个过程 - 信号转导 - 是生物体如何反应和适应环境变化的基础。不幸的是，在疾病状态和环境毒素中，有很多方法可以破坏。对这种干扰的适当治疗需要我们了解所涉及的精确分子机制。我们研究了肌醇多磷酸第二信使的生理作用，特别是INSP6的代谢产物。后者是其他重要衍生物的前体：“焦磷酸化”的多磷酸盐。我们正在探索这些新型代谢产物的重要性，迄今为止发现的信息强烈表明它们是“高能量”分子，它们充当特定环境应激刺激的传感器，包括营养剥夺，代谢炎症和病毒感染。该项目涉及研究人类冠状病毒，新型冠状病毒，Covid-19，严重急性呼吸综合症冠状病毒疾病，SARS冠状病毒，SARS-Coronavirus-2，SARS-COVIRUS-2，SARS-COV-2，SARS-COV-2，SARS-COV2，SARS-COV2，SARS-SARS-COVIRUS 2，与SARS COTIROTIAL CONAVIRUS 2，严重的急性呼吸道呼吸道综合征2与SARS相关的冠状病毒。