Characterising a new regulator of the Hedgehog pathway

表征 Hedgehog 通路的新调节因子

• 批准号: DP240101935
• 负责人: A/Prof Kelly Smith
• 金额: $ 52.31万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101935
• 关键词: Characterising; new; regulator; Hedgehog; pathway

The Hedgehog pathway is crucial for embryonic development, and disruption causes multi-organ morphogenesis defects. The CI team has uncovered a new gene required for Hedgehog signalling in mouse, zebrafish, and Drosophila. Preliminary data hints at mechanism for this novel gene and shows it may in fact be a member of a new superfamily. The project will examine gene function and identify interacting protein partners, using the zebrafish, Drosophila, and cell-based models. Findings will provide basic knowledge about this mysterious gene and uncover how it modulates an essential pathway in embryonic development. This research is expected to impact knowledge generation, health, and well-being.

Hedgehog通路对胚胎发育至关重要，中断会导致多器官形态发生缺陷。CI团队发现了一个新的基因，该基因是小鼠、斑马鱼和果蝇中Hedgehog信号所必需的。初步数据暗示了这种新基因的机制，并表明它实际上可能是一个新的超家族的成员。该项目将研究基因功能，并确定相互作用的蛋白质伴侣，使用斑马鱼，果蝇和基于细胞的模型。研究结果将提供有关这个神秘基因的基本知识，并揭示它如何调节胚胎发育的重要途径。这项研究预计将影响知识的产生，健康和福祉。