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Plug-and-Play High-Order B0 Shimming for Reliable Temporal Lobe Epilepsy Magnetic Resonance Spectroscopic Imaging

即插即用高阶 B0 匀场可实现可靠的颞叶癫痫磁共振波谱成像

基本信息

批准号：
10255978
负责人：
HUI HAN
金额：
$ 35万
依托单位：
LUCIDITY MEDICAL, LLC
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-22 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10255978
关键词：
Adopted Adoption Affect Air Area Body Regions Brain Neoplasms Brain region Businesses Cellular Metabolic Process Clinical Clinical Research Consensus Cyclotrons Data Devices Disease Engineering Entrepreneurship Epilepsy Epileptogenesis Foundations Generations Glioblastoma Head Heating Hippocampus (Brain)Hospitals Image Imaging Techniques Impairment Lesion Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Maps Medical Metabolism Mitochondrial Diseases Modality Multiple Sclerosis Names Nerve Degeneration Neurotransmitters Operative Surgical Procedures Paper Patients Persons Phase Play Positron-Emission Tomography Predisposition Preparation Procedures Process Protons Publishing Research Resolution Sphenoidal sinus Standard Preparations Structure Surface System Techniques Technology Temporal Lobe Temporal Lobe Epilepsy Testing Time Tissues Traumatic Brain Injury Variant Weight Yang analysis pipeline clinical application clinical practice clinical translation design functional disability human subject improved light weight magnetic resonance spectroscopic imaging neocortical nervous system disorder neuroimaging preservation prognostic value radio frequency routine imaging scale up soft tissue spectroscopic imaging surgery outcome tool

项目摘要

Abstract: Epilepsy affects 7 million people globally, and the temporal lobe epilepsy (TLE) is its most common form. For TLE patients that are undergoing surgical treatment, functional neuroimaging is vitally important to localize epileptic focus, maximize the preservation of unaffected areas, and optimize post-surgical outcomes. MR spectroscopic imaging (MRSI) is a promising modality to directly localize abnormalities of metabolites and neurotransmitters in the epileptic focus. To date, multiple clinical studies have demonstrated the prognostic value of MRSI in post-surgical outcomes for TLE and other neurological disorders such as glioblastoma and brain trauma. However, the MRSI image reliability is often impaired by the insufficient B0 field homogeneity in a certain region of the brain. Particularly, the susceptibility mismatch between the air in the sphenoid sinus and temporal lobe(TL) leads to local B0 field distortion, hence disrupt the spectral quality in a major portion of the TL. Although state-of-the-art MRI scanners are equipped with B0 field correcting capability (B0 shimming), it can only correct for slow varying fields and not the higher-order field disturbance at the tissue/air interfaces. In order to provide accurate and reliable MRSI for the temporal lobe, a reliable high-order B0 shimming device that can fit into clinical workflow is highly desirable. There are limited options in the market of high-order B0 shimming devices. The available products are usually too heavy and too complicated to be adopted in a routine clinical setting. In this proposal, we propose a lightweight high-order shim coil that provides reliable whole TL MRSI coverage under standard clinical workflow. Adopting the surface shim/RF coil technology, lightweight coil components, and optimized interface design, a plug-and-play high-order B0 shim coil will be developed and integrated into a clinical high field scanner. The endpoints of this proposal will lay the foundation to enable clinical high-order B0 homogeneity in high field clinical scanners. This will facilitate the clinical translation of state-of-the-art MRSI for temporal lobe epilepsy and other major neurological diseases.

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