Plug-and-Play High-Order B0 Shimming for Reliable Temporal Lobe Epilepsy Magnetic Resonance Spectroscopic Imaging

即插即用高阶 B0 匀场可实现可靠的颞叶癫痫磁共振波谱成像

• 批准号: 10490474
• 负责人: HUI HAN
• 金额: $ 34.93万
• 依托单位: LUCIDITY MEDICAL, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10490474
• 关键词: Adopted; Adoption; Affect; Air; Area; Body Regions; Brain Neoplasms; Brain region; Businesses; Cellular Metabolic Process; Clinical; Clinical Research; Consensus; Cyclotrons; Data; Devices; Disease; Engineering; Entrepreneurship; Epilepsy; Epileptogenesis; Foundations; Generations; Glioblastoma; Head; Heating; Hippocampus (Brain); Hospitals; Image; Imaging Techniques; Impairment; Lesion; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maps; Medical; Metabolism; Mitochondrial Diseases; Modality; Multiple Sclerosis; Names; Nerve Degeneration; Neurotransmitters; Operative Surgical Procedures; Paper; Patients; Persons; Phase; Play; Positron-Emission Tomography; Predisposition; Preparation; Procedures; Process; Protons; Publishing; Research; Resolution; Sphenoidal sinus; Standard Preparations; Structure; Surface; System; Techniques; Technology; Temporal Lobe; Temporal Lobe Epilepsy; Testing; Time; Tissues; Traumatic Brain Injury; Variant; Weight; Yang; analysis pipeline; clinical application; clinical practice; clinical translation; design; functional disability; human subject; improved; light weight; magnetic resonance spectroscopic imaging; neocortical; nervous system disorder; neuroimaging; preservation; prognostic value; radio frequency; routine imaging; scale up; soft tissue; spectroscopic imaging; surgery outcome; tool

Abstract: Epilepsy affects 7 million people globally, and the temporal lobe epilepsy (TLE) is its most common form. For TLE patients that are undergoing surgical treatment, functional neuroimaging is vitally important to localize epileptic focus, maximize the preservation of unaffected areas, and optimize post-surgical outcomes. MR spectroscopic imaging (MRSI) is a promising modality to directly localize abnormalities of metabolites and neurotransmitters in the epileptic focus. To date, multiple clinical studies have demonstrated the prognostic value of MRSI in post-surgical outcomes for TLE and other neurological disorders such as glioblastoma and brain trauma. However, the MRSI image reliability is often impaired by the insufficient B0 field homogeneity in a certain region of the brain. Particularly, the susceptibility mismatch between the air in the sphenoid sinus and temporal lobe(TL) leads to local B0 field distortion, hence disrupt the spectral quality in a major portion of the TL. Although state-of-the-art MRI scanners are equipped with B0 field correcting capability (B0 shimming), it can only correct for slow varying fields and not the higher-order field disturbance at the tissue/air interfaces. In order to provide accurate and reliable MRSI for the temporal lobe, a reliable high-order B0 shimming device that can fit into clinical workflow is highly desirable. There are limited options in the market of high-order B0 shimming devices. The available products are usually too heavy and too complicated to be adopted in a routine clinical setting. In this proposal, we propose a lightweight high-order shim coil that provides reliable whole TL MRSI coverage under standard clinical workflow. Adopting the surface shim/RF coil technology, lightweight coil components, and optimized interface design, a plug-and-play high-order B0 shim coil will be developed and integrated into a clinical high field scanner. The endpoints of this proposal will lay the foundation to enable clinical high-order B0 homogeneity in high field clinical scanners. This will facilitate the clinical translation of state-of-the-art MRSI for temporal lobe epilepsy and other major neurological diseases.

抽象的： 癫痫症影响全球 700 万人，颞叶癫痫 (TLE) 是其最常见的形式。为了 正在接受手术治疗的 TLE 患者，功能性神经影像学对于定位至关重要 癫痫焦点，最大限度地保留未受影响的区域，并优化术后效果。先生 光谱成像（MRSI）是一种有前途的直接定位代谢物异常和 癫痫病灶中的神经递质。迄今为止，多项临床研究已经证明了预后 MRSI 对 TLE 和其他神经系统疾病（例如胶质母细胞瘤和胶质母细胞瘤）术后结果的价值 脑外伤。然而，MRSI 图像的可靠性常常因 B0 场均匀性不足而受到损害。 大脑的某个区域。特别是，蝶窦内的空气和蝶窦内的空气之间的磁化率不匹配。 颞叶 (TL) 会导致局部 B0 场失真，从而破坏大部分频谱的频谱质量 TL。尽管最先进的 MRI 扫描仪配备了 B0 场校正功能（B0 匀场），但它 只能校正缓慢变化的场，而不能校正组织/空气界面处的高阶场扰动。在 为了给颞叶提供准确可靠的MRSI，可靠的高阶B0匀场装置 非常需要能够适应临床工作流程的技术。高阶B0市场选择有限 匀场装置。现有的产品通常太重且太复杂，无法在实际应用中采用。 常规临床环境。在本提案中，我们提出了一种轻量级高阶匀场线圈，可提供可靠的 标准临床工作流程下的整个 TL MRSI 覆盖。采用表面垫片/射频线圈技术， 轻量化的线圈组件，以及优化的接口设计，即插即用的高阶B0匀场线圈 开发并集成到临床高场扫描仪中。该提案的终点将奠定 为在高场临床扫描仪中实现临床高阶 B0 均匀性奠定了基础。这将有利于 最先进的 MRSI 临床转化治疗颞叶癫痫和其他主要神经系统疾病。