A New Multi-functional and Connected Mobile App Guiding Acupressure Use for Self-management and Monitoring of Cancer Related Fatigue and Sleep Disturbances

一款新的多功能互联移动应用程序，指导使用穴位按摩进行自我管理和监测癌症相关的疲劳和睡眠障碍

• 批准号: 10255903
• 负责人: SUSAN L BECK
• 金额: $ 39.74万
• 依托单位: 5 POINT APP
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-16 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10255903
• 关键词: Acupressure; Acupuncture Points; Adherence; Adoption; Affect; Aftercare; American; Apple watch; Biological; Cancer Center; Cancer Fatigue; Cancer Patient; Cancer Survivor; Caregivers; Clinical; Clinical Trials; Competence; Computer Systems; Computer software; Data; Devices; Diagnosis; Distress; Dose; Effectiveness; Emotional; Evaluation; Exercise; Fatigue; Feedback; Funding; Goals; Health; Hospitals; Individual; Instruction; Insurance; Interview; Location; Mainstreaming; Malignant Neoplasms; Marketing; Measures; Medical; Mental Depression; Methods; Modification; Monitor; Nonpharmacologic Therapy; Outcome; Pain; Participant; Patient Self-Report; Patients; Performance; Phase; Protocols documentation; Provider; Quality of life; Questionnaires; Randomized Controlled Trials; Recommendation; Reporting; Research; Sampling; Science; Self Administration; Self Care; Self Management; Sleep; Sleep Deprivation; Sleep disturbances; Small Business Innovation Research Grant; Stream; Symptoms; Techniques; Testing; Time; Treatment-Related Cancer; United States National Institutes of Health; Video Recording; Volatile Oils; cancer care; cancer therapy; clinical care; commercialization; compliance behavior; cost; design; disabling symptom; efficacy evaluation; evidence base; experience; fitbit; fitness; health data; improved; instructor; mHealth; mobile application; novel; pressure; prototype; response; social; symptom treatment; usability

PROJECT SUMMARY Fatigue and sleep disturbances, common, distressing, and debilitating symptoms of cancer and its treatment, negatively impact physical, emotional, and social health of millions of cancer patients. Most of the 1.7 million Americans diagnosed with cancer in 2020 will suffer cancer and treatment-related symptoms; up to 90% receiving treatment experience fatigue; 30% may experience long-lasting fatigue. Sleep disturbances (affecting up to 75% of patients) contribute to poor health and may exacerbate fatigue. Mounting evidence indicates that acupressure, which is unfamiliar and infrequently used by cancer survivors, can reduce fatigue and improve sleep. 5 Point App, Inc. is developing its first mobile health (mHealth) software, EnergyPoints, a patient activation and educational app that offers an opportunity to mainstream acupressure—a beneficial strategy to help cancer patients self-manage their symptoms. The EnergyPoints App will motivate and guide cancer patients to implement daily acupressure protocols to self-manage fatigue and sleep disturbances. The app will connect individual sleep and activity data synced from an Apple Watch/Fitbit with self-reports of symptoms, allowing patients and clinical providers to monitor symptom response to acupressure self-treatment. The long- term goal is to improve quality of life for cancer patients suffering from fatigue and sleep disturbances using acupressure as a safe, universally affordable self-care technique. The team will first develop a fully functional prototype app, validating data accuracy and debugging programming. Specific aim 1 is to confirm cancer patients can accurately and consistently self-administer two acupressure protocols using the app. Specific aim 2 is to assess the usability of the app and the fitness tracker. Using an integrated agile, user-centered approach, 20 patients with cancer who are experiencing fatigue will use the app to self-administer acupressure (twice daily for 1 week) while wearing a fitness tracker. User performance video-recordings, and feedback via talk-aloud session, debriefing, and exit interview, will be used to improve all prototype app features in sprints. Results will provide evidence of feasibility and usability: specifically, the EnergyPoints prototype app can teach and guide cancer patients to perform acupressure as directed, is acceptable, and can connect and accurately share important health data from a fitness tracker. In a subsequent Phase 2 SBIR application, a clinical trial is planned to examine efficacy of the app in improving fatigue and sleep in a sample of cancer patients. Additionally, EnergyPoints App features will be extended by adding: 1) use of essential oils; 2) tailored acupressure delivery; 3) clinical monitoring to integrate with cancer care; 4) social connection features, 5) additional measures (e.g. pain, depression, activation) and 6) compatibility with other trackers (e.g. Amazon Halo). Potential users include millions of cancer patients before and after treatment. The initial commercialization strategy includes multiple revenue streams and marketing directed towards patients, caregivers, practitioners, cancer centers, hospitals, medical practices, and corporate sponsors.

项目摘要 疲劳和睡眠障碍，常见的，令人痛苦的，和衰弱的癌症症状及其治疗， 对数百万癌症患者的身体、情感和社会健康产生负面影响。170万人中的大部分 2020年被诊断患有癌症的美国人将遭受癌症和治疗相关症状;高达90% 接受治疗的人会感到疲劳; 30%的人可能会感到长期疲劳。睡眠障碍（影响 高达75%的患者）导致健康状况不佳，并可能加剧疲劳。越来越多的证据表明， 穴位按摩，这是不熟悉的，很少使用的癌症幸存者，可以减少疲劳，改善 睡吧5 Point App，Inc.正在开发其首款移动的健康（mHealth）软件EnergyPoints， 激活和教育应用程序，提供了一个机会，主流穴位按摩-一个有益的战略， 帮助癌症患者自我控制症状。EnergyPoints应用程序将激励和指导癌症 患者实施每日穴位按摩方案，以自我管理疲劳和睡眠障碍。该应用程序将 将从Apple Watch/Fitbit同步的个人睡眠和活动数据与症状的自我报告联系起来， 允许患者和临床提供者监测穴位按摩自我治疗的症状反应。很长的- 长期目标是改善患有疲劳和睡眠障碍的癌症患者的生活质量 穴位按摩作为一种安全，普遍负担得起的自我保健技术。该团队将首先开发一个功能齐全的 原型应用程序，验证数据的准确性和调试编程。具体目标1是确认癌症 患者可以使用该应用程序准确、一致地自我管理两种针压方案。具体目标 2是评估应用程序和健身追踪器的可用性。使用集成的敏捷、以用户为中心的 20名正在经历疲劳的癌症患者将使用该应用程序来自我管理穴位按摩 （每天两次，持续1周），同时佩戴健身追踪器。用户性能视频记录，并通过 有声会话、汇报和离职面谈，将用于改进sprints中的所有原型应用程序功能。 结果将提供可行性和可用性的证据：具体来说，EnergyPoints原型应用程序可以教 指导癌症患者按指示进行指压，可接受，能衔接准确， 分享来自健身追踪器的重要健康数据。在随后的2期SBIR应用中， 计划在癌症患者样本中检查该应用程序在改善疲劳和睡眠方面的功效。 此外，EnergyPoints应用程序的功能将通过增加：1）使用精油; 2）定制 穴位按摩; 3）与癌症护理相结合的临床监测; 4）社会联系特征，5） 额外的测量（例如疼痛、抑郁、激活）和6）与其他跟踪器（例如亚马逊）的兼容性 Halo）。潜在用户包括治疗前后的数百万癌症患者。初始 商业化策略包括多个收入流和针对患者的营销， 护理人员、从业人员、癌症中心、医院、医疗实践和公司赞助商。