Low Cost, Fully Implantable Wireless Neural Recording Device

低成本、完全植入式无线神经记录设备

• 批准号: 10255016
• 负责人: Roozbeh Ghaffari
• 金额: $ 74.81万
• 依托单位: NEUROLUX, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10255016
• 关键词: 3-Dimensional; Affect; Animal Model; Animals; Behavior; Behavioral; Bluetooth; Body Temperature; Brain; Circadian Rhythms; Communication; Complex; Computer software; Data; Data Display; Data Storage and Retrieval; Development; Devices; Electroencephalogram; Electroencephalography; Electromyography; Electronics; Electrophysiology (science); Environment; Event; Harvest; Home; Impairment; Implant; Implanted Electrodes; Individual; Industry; Industry Standard; Intuition; Laboratories; Longevity; Magnetism; Maintenance; Manufacturer Name; Measurement; Methods; Miniaturization; Mus; Muscle; Neurosciences Research; Outcome; Performance; Phase; Power Sources; Printing; REM Sleep; Rattus; Records; Rodent; Sampling; Signal Transduction; Sleep; Social Interaction; System; Technology; Temperature; Temperature Sense; Testing; Thinness; Time; Validation; Wireless Technology; Work; awake; cost; data acquisition; data exchange; data format; design; experimental study; file format; flexibility; graphical user interface; implantable device; improved; in vivo evaluation; manufacturing process development; miniaturize; neurophysiology; new technology; non rapid eye movement; operation; optogenetics; performance tests; physiologic stressor; printed circuit board; programs; psychological stressor; radio frequency; relating to nervous system; seal; sleep behavior; social; software systems; tool; usability; user friendly software

Project Summary/Abstract The proposed project will develop a device that records brain and muscle signals (electroencephalography and electromyography, EEG/EMG) from behaving rodents without the cumbersome, expensive, and maintenance- intensive wires or batteries that hinder the usefulness of existing commercially available systems. By delivering both power and data wirelessly, and entirely eliminating all external implants on the animal, our technology will extend brain recording capabilities to sensitive behaviors, such as sleep-wake behavior or social interaction, that are easily disrupted by external tethers, and will enable long-term recordings and recordings from animals behaving in three-dimensional naturalistic environments, that are impossible with current technology. Furthermore, the system we will develop is fully compatible with existing NeuroLux HF wireless electronic platform and control software, allowing us to leverage the strengths of an existing commercial platform to further advance neuroscience research capabilities.

项目总结/摘要 拟议的项目将开发一种记录大脑和肌肉信号的设备（脑电图和 肌电图，脑电图/肌电图）从行为啮齿动物没有繁琐，昂贵，和维护- 这阻碍了现有的商业上可获得的系统的有用性。通过提供 无线供电和数据，并完全消除动物身上的所有外部植入物，我们的技术将 将大脑记录能力扩展到敏感行为，如睡眠-觉醒行为或社会互动， 很容易被外部系绳干扰，并将使长期记录和记录动物 在三维自然环境中的行为，这是目前技术所无法实现的。 此外，我们将开发的系统与现有的NeuroLux HF无线电子设备完全兼容 平台和控制软件，使我们能够利用现有商业平台的优势， 提高神经科学研究能力。