Multistage LC-MSn for automated glycan isomer assignment of glycopeptides
用于糖肽自动聚糖异构体分配的多级 LC-MSn
基本信息
- 批准号:10255170
- 负责人:
- 金额:$ 25.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-16 至 2022-10-15
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptedBiologicalBiological Response Modifier TherapyBiologyCatalogsCellsCharacteristicsCommunitiesComplexComputer softwareDataDatabasesDetectionDevelopmentDiagnosticDiscriminationDiseaseDissociationFutureGlycobiologyGlycopeptidesGlycoproteinsImmune responseImmune systemInstitutesIonsIsomerismLaboratoriesLettersLibrariesLinkMass FragmentographyMass Spectrum AnalysisMethodsMilkMonitorMonosaccharidesNoiseOligosaccharidesOnset of illnessOrganismOutcomeOutputPatternPeptidesPhasePlayPolysaccharidesPost-Translational Protein ProcessingProtein GlycosylationProteinsProteomicsProtocols documentationRegulationReproducibilityResearch PersonnelRoleScanningSignal TransductionSiteSmall Business Technology Transfer ResearchSoftware ToolsStructureTestingTherapeuticTimeWorkbasecancer cellcarbohydrate structureglycoproteomicsglycosylationimmunoregulationimplementation toolinsightinstrumentationpathogenpreventprotein aminoacid sequenceprototypestereochemistrysugartandem mass spectrometrytooltumor progressionuser-friendly
项目摘要
N- and O-linked glycosylation are some of the most common, abundant, and biologically
important posttranslational modifications of proteins, yet they are also some of the most difficult
to study. The dominant analytical platform for the study of glycosylation is mass spectrometry,
yet this platform on its own is incomplete, because it cannot elucidate glycan topology and
linkage stereochemistry. This project will advance the use of mass spectrometry for glycan
structure determination, especially for the case of O-linked glycans, by studying the ion
propensities of various structural motifs in multi-stage ion trap mass spectrometry, and by
building new software for structure inference from such mass spectra.
N-和O-连接的糖基化是一些最常见的,丰富的,生物学上的,
重要的蛋白质翻译后修饰,但它们也是一些最困难的
学习用于糖基化研究的主要分析平台是质谱法,
然而,这个平台本身是不完整的,因为它不能阐明聚糖拓扑结构,
键立体化学这个项目将促进质谱法在聚糖中的应用
结构测定,特别是对于O-连接聚糖的情况,通过研究离子
多阶段离子阱质谱中各种结构基序的倾向,以及
建立新的软件来从这样的质谱推断结构。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Miklos Guttman其他文献
Miklos Guttman的其他文献
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{{ truncateString('Miklos Guttman', 18)}}的其他基金
ThermoFisher Scientific Orbitrap Eclipse with ETD and UVPD
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- 批准号:
10427682 - 财政年份:2022
- 资助金额:
$ 25.66万 - 项目类别:
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IgM 介导的补体系统激活机制
- 批准号:
10416077 - 财政年份:2021
- 资助金额:
$ 25.66万 - 项目类别:
Mechanisms of IgM mediated activation of the complement system
IgM 介导的补体系统激活机制
- 批准号:
10296558 - 财政年份:2021
- 资助金额:
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Mechanisms of IgM mediated activation of the complement system
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10640282 - 财政年份:2021
- 资助金额:
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Hybrid structural mass spectrometry for rapid site-specific glycan structural elucidation
用于快速位点特异性聚糖结构解析的混合结构质谱法
- 批准号:
10186777 - 财政年份:2018
- 资助金额:
$ 25.66万 - 项目类别:
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8432517 - 财政年份:2012
- 资助金额:
$ 25.66万 - 项目类别:
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