Multistage LC-MSn for automated glycan isomer assignment of glycopeptides

用于糖肽自动聚糖异构体分配的多级 LC-MSn

基本信息

  • 批准号:
    10255170
  • 负责人:
  • 金额:
    $ 25.66万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-04-16 至 2022-10-15
  • 项目状态:
    已结题

项目摘要

N- and O-linked glycosylation are some of the most common, abundant, and biologically important posttranslational modifications of proteins, yet they are also some of the most difficult to study. The dominant analytical platform for the study of glycosylation is mass spectrometry, yet this platform on its own is incomplete, because it cannot elucidate glycan topology and linkage stereochemistry. This project will advance the use of mass spectrometry for glycan structure determination, especially for the case of O-linked glycans, by studying the ion propensities of various structural motifs in multi-stage ion trap mass spectrometry, and by building new software for structure inference from such mass spectra.
N-和o -链糖基化是最常见、最丰富和最具生物学意义的

项目成果

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专利数量(0)

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Miklos Guttman其他文献

Miklos Guttman的其他文献

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{{ truncateString('Miklos Guttman', 18)}}的其他基金

ThermoFisher Scientific Orbitrap Eclipse with ETD and UVPD
带 ETD 和 UVPD 的 ThermoFisher Scientific Orbitrap Eclipse
  • 批准号:
    10427682
  • 财政年份:
    2022
  • 资助金额:
    $ 25.66万
  • 项目类别:
Mechanisms of IgM mediated activation of the complement system
IgM 介导的补体系统激活机制
  • 批准号:
    10416077
  • 财政年份:
    2021
  • 资助金额:
    $ 25.66万
  • 项目类别:
Mechanisms of IgM mediated activation of the complement system
IgM 介导的补体系统激活机制
  • 批准号:
    10296558
  • 财政年份:
    2021
  • 资助金额:
    $ 25.66万
  • 项目类别:
Mechanisms of IgM mediated activation of the complement system
IgM 介导的补体系统激活机制
  • 批准号:
    10640282
  • 财政年份:
    2021
  • 资助金额:
    $ 25.66万
  • 项目类别:
Hybrid structural mass spectrometry for rapid site-specific glycan structural elucidation
用于快速位点特异性聚糖结构解析的混合结构质谱法
  • 批准号:
    10186777
  • 财政年份:
    2018
  • 资助金额:
    $ 25.66万
  • 项目类别:
Investigating the Architecture of HIV Envelope Glycoprotein
研究 HIV 包膜糖蛋白的结构
  • 批准号:
    8262992
  • 财政年份:
    2012
  • 资助金额:
    $ 25.66万
  • 项目类别:
Investigating the Architecture of HIV Envelope Glycoprotein
研究 HIV 包膜糖蛋白的结构
  • 批准号:
    8432517
  • 财政年份:
    2012
  • 资助金额:
    $ 25.66万
  • 项目类别:

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