Cortical encoding of unconscious visual information and its impact on behavior
无意识视觉信息的皮质编码及其对行为的影响
基本信息
- 批准号:10256012
- 负责人:
- 金额:$ 37.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-30 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:Age related macular degenerationAmblyopiaAnimalsAreaAttentionAwarenessBase of the BrainBehaviorBehavioralBrainCellsCodeComplexConsciousDiabetic RetinopathyDiscriminationElectrodesExhibitsExposure toGoalsHumanImageIndividualLeadLearningLifeLinkMacacaMasksNeuronsPerceptionPerformancePopulationPropertyResearchResolutionSensoryStimulusStrokeSubliminal StimulationTechniquesTestingTimeUnconscious StateV1 neuronV4 neuronVisionVisual CortexVisual PerceptionVisual impairmentarea V1area V4basecalmodulin-dependent protein kinase IIeffective therapyexperienceexperimental studyimprovedmillisecondneuronal circuitrynonhuman primatenoveloptogeneticspromoterreceptive fieldrelating to nervous systemresponsespatiotemporalstimulus processingvisual informationvisual stimulus
项目摘要
PROJECT SUMMARY/ABSTRACT
Stimuli presented too briefly to be noticed can nonetheless facilitate the perceptual processing of the same
stimuli many minutes later. Whereas the phenomenon of subliminal priming has been known for decades,
whether and how sensory information is encoded in the brain in the absence of awareness in a way that
influences subsequent sensory processing across neuronal circuits remains a mystery. We will answer these
questions for the first time by examining, at single cell resolution, whether exposure to subliminal stimuli
influences perceptual performance and the coding of information across visual cortical populations. To
accomplish this goal, we will use multiple-electrode recording of single-unit activity in macaque early and mid-
level visual cortical areas (V1 and V4) and behavioral techniques to examine the dynamics and coding in
neuronal populations during and after subliminal exposure, and their impact on perceptual performance. Aim 1
will investigate whether exposure to subliminal stimuli increases subsequent perceptual performance and the
amount of information encoded in population activity. Our hypothesis is that subliminal exposure improves
perceptual discrimination performance when stimuli are subsequently presented above the detectability
threshold, and increases the amount of information extracted from the population response. Aim 2 will examine
the mechanism of the improvement in neuronal and behavioral performance after subliminal exposure. We will
first focus on causal experiments involving optogenetic inactivation which will test whether suppressing
neuronal activity in visual cortex during the presentation of subliminal stimuli reduces the strength of subliminal
priming. Cross-correlation analysis will subsequently test whether improved network and perceptual
performance after subliminal exposure is consistent with a Hebbian mechanism underlying the increase in
functional connectivity specifically for the neurons activated by subthreshold stimuli. Aim 3 will examine the
impact of attention on the relationship between subliminal priming and neuronal and perceptual performance.
We will test the novel hypothesis that spatial attention reduces the efficacy of subliminal priming – exposure to
unattended subliminal stimulation will be associated with a larger improvement in network coding and
perceptual performance compared to exposure to attended information. In contrast, we expect that attention
will increase the strength of supraliminal priming, i.e., exposure to attended subliminal stimulation will be
associated with a larger improvement in network coding and perceptual performance compared to exposure to
unattended information. Taken together, our proposed experiments can potentially advance our understanding
of information coding in visual cortex by testing the limits of sensory experience and its relationship with
perception, which will help develop effective therapies to treat the brain-based aspects of low vision conditions,
such as amblyopia, age-related macular degeneration, diabetic retinopathy, or stroke.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
VALENTIN DRAGOI其他文献
VALENTIN DRAGOI的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('VALENTIN DRAGOI', 18)}}的其他基金
Neural coding of natural stimuli in freely moving macaque
自由移动猕猴自然刺激的神经编码
- 批准号:
10524592 - 财政年份:2022
- 资助金额:
$ 37.2万 - 项目类别:
Cortical encoding of unconscious visual information and its impact on behavior
无意识视觉信息的皮质编码及其对行为的影响
- 批准号:
10440471 - 财政年份:2020
- 资助金额:
$ 37.2万 - 项目类别:
Cortical encoding of unconscious visual information and its impact on behavior
无意识视觉信息的皮质编码及其对行为的影响
- 批准号:
10653902 - 财政年份:2020
- 资助金额:
$ 37.2万 - 项目类别:
The Impact of Sleep on Network Coding and Perceptual Performance
睡眠对网络编码和感知性能的影响
- 批准号:
9565710 - 财政年份:2016
- 资助金额:
$ 37.2万 - 项目类别:
Administrative Supplement: Anion channelrhodopsin-based viral tools to manipulate brain networks in behaving animals
行政补充:基于阴离子通道视紫红质的病毒工具可操纵行为动物的大脑网络
- 批准号:
9268890 - 财政年份:2016
- 资助金额:
$ 37.2万 - 项目类别:
The Impact of Sleep on Network Coding and Perceptual Performance
睡眠对网络编码和感知性能的影响
- 批准号:
10543110 - 财政年份:2016
- 资助金额:
$ 37.2万 - 项目类别:
The Impact of Sleep on Network Coding and Perceptual Performance
睡眠对网络编码和感知性能的影响
- 批准号:
10392202 - 财政年份:2016
- 资助金额:
$ 37.2万 - 项目类别:
Anion channelrhodopsin-based viral tools to manipulate brain networks in behaving animals
基于阴离子通道视紫红质的病毒工具可操纵行为动物的大脑网络
- 批准号:
9321918 - 财政年份:2015
- 资助金额:
$ 37.2万 - 项目类别:
Examining Population Coding Underlying Complex Behavior in Freely Moving Primates
检查自由活动的灵长类动物复杂行为背后的群体编码
- 批准号:
7979898 - 财政年份:2010
- 资助金额:
$ 37.2万 - 项目类别:
相似海外基金
Interocular Suppression and Selective Attention in Amblyopia
弱视的眼间抑制和选择性注意
- 批准号:
10720187 - 财政年份:2023
- 资助金额:
$ 37.2万 - 项目类别:
Community-based amblyopia screening using a novel device
使用新型设备进行社区弱视筛查
- 批准号:
10641301 - 财政年份:2023
- 资助金额:
$ 37.2万 - 项目类别:
Orientation Processing Deficits in Amblyopia: Neural Bases to Functional Implications
弱视的定向处理缺陷:神经基础到功能意义
- 批准号:
10649039 - 财政年份:2023
- 资助金额:
$ 37.2万 - 项目类别:
Improvement of visual and motor functions in patients with amblyopia after binocular training
双眼训练后弱视患者视觉和运动功能的改善
- 批准号:
22KF0354 - 财政年份:2023
- 资助金额:
$ 37.2万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Amblios Club: Human-Centred AI and Gamification for Amblyopia Self-Care
Amblios Club:以人为本的人工智能和游戏化弱视自我护理
- 批准号:
10044253 - 财政年份:2022
- 资助金额:
$ 37.2万 - 项目类别:
Grant for R&D
Stereopsis and Suppression in Strabismus and Amblyopia
斜视和弱视的立体视觉和抑制
- 批准号:
10539773 - 财政年份:2022
- 资助金额:
$ 37.2万 - 项目类别:
Development of a treatment for amblyopia using new diffusion filters considering the critical period of the eye using visual evoked potentials.
考虑到眼睛的关键期,使用视觉诱发电位,开发使用新型扩散滤光器治疗弱视的方法。
- 批准号:
22K13673 - 财政年份:2022
- 资助金额:
$ 37.2万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Behavioural Assessment of Amblyopia in an Animal Model
动物模型中弱视的行为评估
- 批准号:
572332-2022 - 财政年份:2022
- 资助金额:
$ 37.2万 - 项目类别:
University Undergraduate Student Research Awards
Stereopsis and Suppression in Strabismus and Amblyopia
斜视和弱视的立体视觉和抑制
- 批准号:
10673775 - 财政年份:2022
- 资助金额:
$ 37.2万 - 项目类别:
Spatial Frequency Dependent Deficits in Anisometropic Amblyopia
屈光参差性弱视的空间频率依赖性缺陷
- 批准号:
10704166 - 财政年份:2022
- 资助金额:
$ 37.2万 - 项目类别: