An Acoustofluidic Device for Biocompatible Platelet Separation

用于生物相容性血小板分离的声流控装置

基本信息

  • 批准号:
    10256156
  • 负责人:
  • 金额:
    $ 77.13万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-09-15 至 2023-05-31
  • 项目状态:
    已结题

项目摘要

Abstract Isolating a high-purity, high-quality, and high-concentration platelet sample in an efficient and cost- effective manner is of paramount importance to both hematological research and clinical therapy settings. Even though there are several methods for isolating platelets on the market today, most current methods have low biocompatibility (i.e., activate platelets, alter their morphology, and reduce membrane integrity during the platelet separation process). These drawbacks detract from the overall utility of current practices, and can even have a negative impact on patients. For example, measurements of platelet units in U.S. hospitals have found that platelet activation rates range between 23% to 50%. Studies have shown that when patients receive activated platelets, they require more platelet transfusion than patients who receive non-activated platelets. Overall, up to 30% of platelet transfusions performed in the U.S. are ineffective. Although there are many factors that influence the clinical outcomes of platelet transfusions, the quality of isolated platelets has been shown to play a crucial role. The objective of this SBIR project is to overcome the limitations of existing platelet separation technologies and address the unmet needs in the market by developing and commercializing a biocompatible platelet separation and enrichment platform using acoustofluidic (i.e., the fusion of acoustics and fluid mechanics) technologies. During our work on the Phase I project, we successfully demonstrated the utility and feasibility of the proposed biocompatible platelet separation and enrichment devices by meeting or exceeding the target values for each of the six key parameters identified in the Measures of Success. In Phase II, our commercialization activities will improve the performance of the acoustofluidic-based platelet separation and enrichment chips, develop self-contained, beta-testing-ready prototypes, and validate their performance with end users. The proposed acoustofluidic technology will have significantly improved biocompatibility when compared to the benchmark technologies (isolating platelets that are more morphologically and chemically intact). We believe that our superior biocompatibility compared to traditional platelet isolation techniques will enable the development and commercialization of an acoustofluidic platform that has the potential to significantly improve the effectiveness, speed, and economy of both clinical and research applications of platelets.
摘要

项目成果

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Lin Wang其他文献

Lin Wang的其他文献

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{{ truncateString('Lin Wang', 18)}}的其他基金

An acoustofluidic device for diagnosing preclinical Alzheimer's disease
用于诊断临床前阿尔茨海默病的声流控装置
  • 批准号:
    10325078
  • 财政年份:
    2019
  • 资助金额:
    $ 77.13万
  • 项目类别:
Development of an acoustofluidic device for high-throughput 3D imaging and sorting of C. elegans
开发用于线虫高通量 3D 成像和分选的声流控装置
  • 批准号:
    10618824
  • 财政年份:
    2018
  • 资助金额:
    $ 77.13万
  • 项目类别:
Development of an acoustofluidic device for high-throughput 3D imaging and sorting of C. elegans
开发用于线虫高通量 3D 成像和分选的声流控装置
  • 批准号:
    10383627
  • 财政年份:
    2018
  • 资助金额:
    $ 77.13万
  • 项目类别:
An Acoustofluidic Device for Biocompatible Platelet Separation
用于生物相容性血小板分离的声流控装置
  • 批准号:
    10458102
  • 财政年份:
    2018
  • 资助金额:
    $ 77.13万
  • 项目类别:
An Acoustofluidic Device for Point-of-Care Sputum Processing and Analysis
用于床旁痰液处理和分析的声流控装置
  • 批准号:
    8839460
  • 财政年份:
    2014
  • 资助金额:
    $ 77.13万
  • 项目类别:

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