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An Acoustofluidic Device for Biocompatible Platelet Separation

用于生物相容性血小板分离的声流控装置

基本信息

批准号：
10256156
负责人：
Lin Wang
金额：
$ 77.13万
依托单位：
ASCENT BIO-NANO TECHNOLOGIES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10256156
关键词：
Acoustics Address Affect Animal Model Benchmarking Biochemical Biological Biomedical Research Blood Blood Cells Blood Component Removal Blood Platelets Blood coagulation Chemicals Clinical Clinical Research Collection Custom Development Devices Effectiveness Electronics Ensure Excision Feedback Goals Gold Half-Life Hematology Hemorrhage Hospitals Host Defense In Vitro Industry Standard Laboratories Life Liquid substance Measurement Measures Mechanics Medical Device Membrane Methods Military Personnel Morphology Neoplasm Metastasis Oncology Outcome Patients Performance Phase Physiological Processes Platelet Activation Platelet Count measurement Platelet Transfusion Play Procedures Process Property Reporting Research Research Personnel Resources Rest Role Rural Sampling Savings Series Small Business Innovation Research Grant Speed System Systems Integration Techniques Technology Test Result Testing Therapeutic Transfusion Universities Whole Blood Work base biomaterial compatibility clinical application commercialization cost effective design improved in vivo instrument meetings microsystems nanobiotechnology nanoparticle point of care portability prevent prototype success tool tumor wound healing

项目摘要

Abstract Isolating a high-purity, high-quality, and high-concentration platelet sample in an efficient and cost- effective manner is of paramount importance to both hematological research and clinical therapy settings. Even though there are several methods for isolating platelets on the market today, most current methods have low biocompatibility (i.e., activate platelets, alter their morphology, and reduce membrane integrity during the platelet separation process). These drawbacks detract from the overall utility of current practices, and can even have a negative impact on patients. For example, measurements of platelet units in U.S. hospitals have found that platelet activation rates range between 23% to 50%. Studies have shown that when patients receive activated platelets, they require more platelet transfusion than patients who receive non-activated platelets. Overall, up to 30% of platelet transfusions performed in the U.S. are ineffective. Although there are many factors that influence the clinical outcomes of platelet transfusions, the quality of isolated platelets has been shown to play a crucial role. The objective of this SBIR project is to overcome the limitations of existing platelet separation technologies and address the unmet needs in the market by developing and commercializing a biocompatible platelet separation and enrichment platform using acoustofluidic (i.e., the fusion of acoustics and fluid mechanics) technologies. During our work on the Phase I project, we successfully demonstrated the utility and feasibility of the proposed biocompatible platelet separation and enrichment devices by meeting or exceeding the target values for each of the six key parameters identified in the Measures of Success. In Phase II, our commercialization activities will improve the performance of the acoustofluidic-based platelet separation and enrichment chips, develop self-contained, beta-testing-ready prototypes, and validate their performance with end users. The proposed acoustofluidic technology will have significantly improved biocompatibility when compared to the benchmark technologies (isolating platelets that are more morphologically and chemically intact). We believe that our superior biocompatibility compared to traditional platelet isolation techniques will enable the development and commercialization of an acoustofluidic platform that has the potential to significantly improve the effectiveness, speed, and economy of both clinical and research applications of platelets.

摘要