An Acoustofluidic Device for Biocompatible Platelet Separation
用于生物相容性血小板分离的声流控装置
基本信息
- 批准号:10256156
- 负责人:
- 金额:$ 77.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-15 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AcousticsAddressAffectAnimal ModelBenchmarkingBiochemicalBiologicalBiomedical ResearchBloodBlood CellsBlood Component RemovalBlood PlateletsBlood coagulationChemicalsClinicalClinical ResearchCollectionCustomDevelopmentDevicesEffectivenessElectronicsEnsureExcisionFeedbackGoalsGoldHalf-LifeHematologyHemorrhageHospitalsHost DefenseIn VitroIndustry StandardLaboratoriesLifeLiquid substanceMeasurementMeasuresMechanicsMedical DeviceMembraneMethodsMilitary PersonnelMorphologyNeoplasm MetastasisOncologyOutcomePatientsPerformancePhasePhysiological ProcessesPlatelet ActivationPlatelet Count measurementPlatelet TransfusionPlayProceduresProcessPropertyReportingResearchResearch PersonnelResourcesRestRoleRuralSamplingSavingsSeriesSmall Business Innovation Research GrantSpeedSystemSystems IntegrationTechniquesTechnologyTest ResultTestingTherapeuticTransfusionUniversitiesWhole BloodWorkbasebiomaterial compatibilityclinical applicationcommercializationcost effectivedesignimprovedin vivoinstrumentmeetingsmicrosystemsnanobiotechnologynanoparticlepoint of careportabilitypreventprototypesuccesstooltumorwound healing
项目摘要
Abstract
Isolating a high-purity, high-quality, and high-concentration platelet sample in an efficient and cost-
effective manner is of paramount importance to both hematological research and clinical therapy
settings. Even though there are several methods for isolating platelets on the market today, most current
methods have low biocompatibility (i.e., activate platelets, alter their morphology, and reduce membrane
integrity during the platelet separation process). These drawbacks detract from the overall utility of
current practices, and can even have a negative impact on patients. For example, measurements of
platelet units in U.S. hospitals have found that platelet activation rates range between 23% to 50%.
Studies have shown that when patients receive activated platelets, they require more platelet transfusion
than patients who receive non-activated platelets. Overall, up to 30% of platelet transfusions performed
in the U.S. are ineffective. Although there are many factors that influence the clinical outcomes of platelet
transfusions, the quality of isolated platelets has been shown to play a crucial role. The objective of this
SBIR project is to overcome the limitations of existing platelet separation technologies and address the
unmet needs in the market by developing and commercializing a biocompatible platelet separation and
enrichment platform using acoustofluidic (i.e., the fusion of acoustics and fluid mechanics) technologies.
During our work on the Phase I project, we successfully demonstrated the utility and feasibility of the
proposed biocompatible platelet separation and enrichment devices by meeting or exceeding the target
values for each of the six key parameters identified in the Measures of Success. In Phase II, our
commercialization activities will improve the performance of the acoustofluidic-based platelet separation
and enrichment chips, develop self-contained, beta-testing-ready prototypes, and validate their
performance with end users. The proposed acoustofluidic technology will have significantly improved
biocompatibility when compared to the benchmark technologies (isolating platelets that are more
morphologically and chemically intact). We believe that our superior biocompatibility compared to
traditional platelet isolation techniques will enable the development and commercialization of an
acoustofluidic platform that has the potential to significantly improve the effectiveness, speed, and
economy of both clinical and research applications of platelets.
摘要
以高效和低成本的方式分离高纯度、高质量和高浓度的血小板样本,
有效的方法对血液学研究和临床治疗都至关重要
设置.尽管目前市场上有几种用于分离血小板的方法,但大多数目前的方法都是在血小板中进行的。
方法具有低的生物相容性(即,激活血小板,改变其形态,并减少膜
血小板分离过程中的完整性)。这些缺点减损了本发明的整体效用。
目前的做法,甚至可能对患者产生负面影响。例如,测量
美国医院的血小板单位发现,血小板活化率在23%至50%之间。
研究表明,当患者接受活化血小板时,需要输注更多的血小板
接受非活化血小板治疗的患者。总体而言,高达30%的血小板输注
在美国是无效的。虽然影响血小板输注治疗临床结局的因素很多,
在输血中,分离的血小板的质量已被证明起着至关重要的作用。的目的
SBIR项目旨在克服现有血小板分离技术的局限性,
通过开发和商业化生物相容性血小板分离,
使用声流体的富集平台(即,声学和流体力学的融合)技术。
在第一期工程的工作中,我们成功地证明了
所提出的生物相容性血小板分离和富集装置通过达到或超过目标
成功的衡量标准中确定的六个关键参数中的每一个的值。在第二阶段,我们
商业化活动将改善基于声流体的血小板分离的性能
和浓缩芯片,开发独立的,beta测试就绪的原型,并验证其
最终用户的性能。所提出的声流技术将大大改善
与基准技术(分离血小板,
形态和化学上完整)。我们相信,与
传统的血小板分离技术将使血小板分离技术的开发和商业化成为可能。
声流体平台,有可能显着提高效率,速度,
血小板临床和研究应用的经济性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
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{{ truncateString('Lin Wang', 18)}}的其他基金
An acoustofluidic device for diagnosing preclinical Alzheimer's disease
用于诊断临床前阿尔茨海默病的声流控装置
- 批准号:
10325078 - 财政年份:2019
- 资助金额:
$ 77.13万 - 项目类别:
Development of an acoustofluidic device for high-throughput 3D imaging and sorting of C. elegans
开发用于线虫高通量 3D 成像和分选的声流控装置
- 批准号:
10618824 - 财政年份:2018
- 资助金额:
$ 77.13万 - 项目类别:
Development of an acoustofluidic device for high-throughput 3D imaging and sorting of C. elegans
开发用于线虫高通量 3D 成像和分选的声流控装置
- 批准号:
10383627 - 财政年份:2018
- 资助金额:
$ 77.13万 - 项目类别:
An Acoustofluidic Device for Biocompatible Platelet Separation
用于生物相容性血小板分离的声流控装置
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10458102 - 财政年份:2018
- 资助金额:
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