A Novel, Low-Cost, Handheld, 3D Imaging System for Improved Screening of Cervical Neoplasia in Resource Limited Settings

一种新型、低成本、手持式 3D 成像系统，可在资源有限的情况下改进宫颈肿瘤的筛查

• 批准号: 10259051
• 负责人: Joseph Carson
• 金额: $ 40万
• 依托单位: PENSIEVISION, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10259051
• 关键词: 3-Dimensional; Address; Advisory Committees; Advocate; Africa South of the Sahara; Anatomy; Area; Award; Biological Assay; Cause of Death; Cellular Phone; Cervical; Cervix Neoplasms; Cessation of life; Clinic; Clinical; Clinical Data; Color; Colposcopy; Computer software; Country; Data; Data Analytics; Detection; Developed Countries; Developing Countries; Development; Devices; Diagnosis; Diagnostic; Discipline of obstetrics; Disease; Disease Management; Doctor of Philosophy; Early Diagnosis; Early treatment; Eligibility Determination; Engineering; Europe; Future; Gynecologic Oncology; Gynecology; Head; Health Care Costs; Health financing; Healthcare; Hospitals; Human Papillomavirus; Human Resources; Image; Imaging Device; Imaging technology; Incidence; Income; Industry Standard; International; Intervention; Legal patent; Lesion; Letters; Light; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Measurable; Measurement; Medical Students; Methods; Mozambique; Pap smear; Patients; Phase; Photography; Publishing; Reproductive Health; Research; Resources; Role; Sales; Screening procedure; Second Opinions; Services; Shapes; Small Business Innovation Research Grant; Stream; Technology; Telemedicine; Telephone; Testing; The Sun; Three-Dimensional Imaging; Time; Tissues; Training; United States National Aeronautics and Space Administration; United States National Institutes of Health; Universities; Visit; Visual; Woman; Work; World Health Organization; anticancer research; cancer care; cancer therapy; cervical cancer prevention; clinically relevant; cost; cost effective; digital imaging; follow-up; health care service organization; high resolution imaging; image registration; imaging software; imaging system; improved; innovation; low and middle-income countries; microsystems; novel; phase 1 study; point of care; portability; premalignant; prevent; product development; programs; remote diagnosis; response; screening; screening program; skin lesion; socioeconomic disadvantage; success; tool; translational medicine; treatment duration; treatment program; virtual

Abstract Cervical cancer is one of the most preventable and treatable forms of cancer, reflected by the fact that its incidence has significantly fallen in most of the developed world over the past 30 years, largely due to effective screening and treatment programs. In developing countries and also in socio-economic disadvantaged areas of developed countries, many women lack convenient access to affordable and high-quality programs to save their lives. Currently, more than a million women worldwide have cervical cancer. Most of these women do not have access to diagnoses and treatments that could cure them or prolong their lives. In 2012, >500,000 new cases of cervical cancer were diagnosed worldwide, and >250,000 of these women died of the disease -- nearly 90% in low- to middle-income countries. Deaths due to cervical cancer are projected to rise by almost 25% over the next 10 years without proper interventions. New technological developments offer the potential to make comprehensive cervical cancer care feasible and affordable in low- and middle-income countries, and to mitigate the skyrocketing healthcare costs in the developed world. In response, we have recently developed (through support from an NSF-SBIR award) a portable, low-cost, simple-to-use, telemedicine- and patient-friendly innovative imaging system that can help advance toward the screen-and-treat strategy for cervical cancer prevention advocated by the World Health Organization. In this phase I study, we will develop and establish feasibility of our screening protocols and advance the overall technology.

抽象的 宫颈癌是最可预防和最可治疗的癌症形式之一，反映 事实上，过去大多数发达国家的发病率已显着下降 30年来，很大程度上归功于有效的筛查和治疗计划。在发展中国家 而且在发达国家的社会经济弱势地区，许多妇女缺乏 方便地获得负担得起的高质量计划来挽救他们的生命。目前，更多 全球有超过一百万女性患有宫颈癌。这些妇女中的大多数没有机会 可以治愈他们或延长他们生命的诊断和治疗。 2012年新增超过50万辆 全世界诊断出宫颈癌病例，其中超过 250,000 名妇女死于宫颈癌 疾病——近90%发生在低收入和中等收入国家。因宫颈癌死亡的人数为 如果没有适当的干预，预计未来 10 年将增长近 25%。新的 技术发展提供了全面宫颈癌护理的潜力 在低收入和中等收入国家可行且负担得起，并缓解飙升的 发达国家的医疗保健费用。作为回应，我们最近开发了（通过 NSF-SBIR 奖项的支持）一种便携式、低成本、易于使用的远程医疗和 患者友好的创新成像系统，有助于推进筛查和治疗 世界卫生组织倡导的宫颈癌预防策略。在这个 第一阶段研究，我们将开发和建立我们的筛选方案的可行性并推进 整体技术。