Flexible, lightweight coils for radiation-transparent multi-modality imaging

灵活、轻便的线圈，用于辐射透明的多模态成像

• 批准号: 10258837
• 负责人: Gillian Gentry Haemer
• 金额: $ 87.12万
• 依托单位: INKSPACE IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10258837
• 关键词: Adult; Amplifiers; Anatomy; Attention; Attenuated; Childhood; Clinical; Conformal Radiotherapy; Data Analyses; Data Set; Development; Devices; Dose; Elements; Ensure; Equipment; Frequencies; Gamma Rays; Goals; Head and neck structure; Housing; Hybrids; Image; Immobilization; Individual; Industry Standard; Intention; Ionizing radiation; Knowledge; Magnetic Resonance Imaging; Maps; Mechanics; Methodology; Modality; Morphologic artifacts; Motion; Multimodal Imaging; Neck; Newborn Infant; Outcome; PET/CT scan; Patient Care; Patient-Focused Outcomes; Patients; Performance; Phase; Positron-Emission Tomography; Radiation; Radiation Dose Unit; Radiation therapy; Research; Research Personnel; Safety; Shapes; Skin; Small Business Innovation Research Grant; System; Technology; Testing; Variant; Vertebral column; X-Ray Computed Tomography; attenuation; base; density; design; experience; flexibility; image guided radiation therapy; imaging modality; imaging system; improved; interest; light weight; magnetic field; multimodality; new technology; pediatric patients; quantitative imaging; radio frequency; simulation; soft tissue; success; tool; treatment planning

Project Abstract Magnetic resonance imaging (MRI) provides high dynamic range soft tissue contrast and full volumetric data sets without the use of ionizing radiation. The combination of MR imaging with other imaging and treatment modalities, specifically with Positron Emission Tomography (PET/MR) and radiation therapy (MR guided Radiation Therapy, MRgRT), has gained attention as technological advances in these systems have allowed for their release into the clinical workflow. MR image quality is directly dependent on RF coil arrays, localized antennae that serve as the main component of the receive chain; and coil performance is dependent on proximity to the anatomy of interest, so most MR systems use a suite of anatomy specific arrays for various applications. However, in hybrid systems 𝛾-ray interactions with these coil arrays is a significant obstacle to patient care, limiting image quality in PET/MR and contributing to decreased target dose and increased skin dose from scattering in MRgRT. Additionally, their traditionally bulky and rigid form can render them incompatible with RT immobilization hardware, especially for head and neck imaging. Incompatibility with immobilization hardware also limits the use of MR imaging for radiation therapy simulation before treatment (MR-Sim). Our goal is to develop a suite of flexible, conformal, radiation transparent head/neck arrays that are compatible with PET/MR, MRgRT, MR-Sim and traditional MRI. Phase I SBIR Specific Aims focused on optimizing coil and hardware technology for radiation-transparency and MR performance, developing and testing a 24-channel flexible array for 3T PET/MR, and analyzing the feasibility of scaling this technology to other field strengths and coil designs. The objectives of this Phase II proposal center around the application of this novel technology to an open market need: conformal head/neck arrays for multi-modality systems compatible with varying patient anatomies. Because commercially available PET/MR and MRgRT systems cover a large range of MR system frequencies, coil development will be pursued at the most clinically impactful field strengths for multi-modality MR systems: 3T, 1.5T, and 0.35T. Our project will produce a head/neck array suite, covering patients from pediatric to adult, and will be designed to ensure consistent performance in the upper c-spine and neck despite highly variable patient anatomies. This suite of coils will include small, medium, and large arrays (24- 28- and 32-channels respectively) which attach to the system through a universal cable and connector and are compatible with standard head/neck immobilization hardware. By completing these goals, we aim to improve patient experience and outcomes by producing an optimized suite of head/neck coils for 3T MR/PET, 1.5T MRgRT, and all MR-Sim systems, and developing the technology for expansion to 0.35T MRgRT.

项目摘要 磁共振成像(MRI)提供高动态范围软组织对比度和全体积数据 在不使用电离辐射的情况下设置。磁共振成像与其他成像和治疗的结合 方式，特别是正电子发射断层扫描(PET/MR)和放射治疗(MR引导 放射疗法，MRGRT)，因为这些系统的技术进步使 它们被释放到临床工作流程中。磁共振图像质量直接取决于射频线圈阵列，局部化 作为接收链的主要组件的天线；线圈的性能取决于距离 对于感兴趣的解剖，因此大多数MR系统使用一套解剖特定的阵列用于各种应用。 然而，在混合系统中，𝛾-射线与这些线圈阵列的相互作用是患者护理的重大障碍， 限制了PET/MR的图像质量，并有助于降低目标剂量和增加皮肤剂量 散射在MRGRT中。此外，它们传统上笨重僵硬的形式可能会使它们与RT不兼容 固定硬件，尤指用于头部和颈部成像的。与固定化硬件不兼容 也限制了磁共振成像用于治疗前放射治疗模拟(MR-Sim)的使用。我们的目标是 开发一套灵活的、共形的、辐射透明的与PET/MR兼容的头/颈阵列， MRGRT、MR-SIM和传统MRI。第一阶段SBIR的具体目标是优化线圈和硬件 辐射透明和磁共振性能技术，开发和测试24通道柔性阵列 对于3T PET/MR，并分析了将该技术扩展到其他场强和线圈设计的可行性。 此第二阶段提案的目标是将这项新技术应用于开放市场 需要：用于多模式系统的共形头/颈阵列，与不同的患者解剖结构兼容。 因为商业上可用的PET/MR和MRGRT系统覆盖了大范围的MR系统频率， 对于多模式磁共振系统，线圈的开发将以最具临床影响力的磁场强度进行： 3T、1.5T和0.35T。我们的项目将生产一个头/颈阵列套件，覆盖从儿科到成人的患者， 并将被设计为确保在高度可变的情况下，上c-脊柱和颈部的性能保持一致 病人的解剖学。这套线圈将包括小型、中型和大型阵列(24-28和32-通道 分别)，它们通过通用电缆和连接器连接到系统并与 标准的头/颈固定硬件。通过完成这些目标，我们的目标是改善患者体验 通过为3T MR/PET、1.5T MRgRT和ALL MR-SIM生产一套优化的头/颈线圈 系统，并开发扩展到0.35T MRGRT的技术。