NCI Program for Natural Products Discovery - Cures

该计划的头两年包括采取必要步骤建立该计划。也就是说，将基础设施放在适当的位置，以启用自动提取、预分馏和提取库的初始纯化。这包括：翻新实验室空间，购买设备以扩大生产规模并使其上线，创建标准操作程序以及招聘和培训员工。此外，正在开发一个生物信息学平台，其中将包括一个内部数据库和面向公众的工具。在过去的一年里，我们看到了该计划的公开宣布，发表了三篇重要的手稿，描述了该计划、预分离方法、活性天然产物的二次纯化以及天然产物库的创建和筛选。此外，我们现在已经向研究社区发布了第一批326,000个NP分数。在本财政年度，250万份馏分已运往各个筛选实验室。此外，还获得了IBC和USDA的批准，允许微生物提取物生产设施开始工作。此外，从澳洲进口海洋无脊椎动物样本4500份及海洋微生物样本6700份。

The first two years of this program involved taking the necessary steps to establish this program. That is, putting the infrastructure in place to enable the automated extraction, pre-fractionation and initial purification of the extract library. This included: renovating laboratory space, purchasing equipment to scale up production and getting it online and creating standard operating procedures as well as hiring and training staff. In addition, a bioinformatics platform is being developed which will include an internal database and public-facing tools. This past year has seen the public announcement of the program, the publication of three significant manuscripts describing the program, the pre fractionation methodology, the secondary purification of active natural products and the crating and screening of natural product libraries. In addition we have now released the first 326,000 NP fractions to the research community. In this fiscal year, 2,500,000 fractions have been shipped to various screening laboratories. In addition IBC and USDA approvals were obtained to allow the microbial extract production facility to begin work. In addition 4500 marine invertebrate samples and 6700 marine microbe samples were imported from Australia.