Methylation Array Profiling as a New Clinical Diagnostic Test

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Another milestone in Chromosome Pathology Section is the introduction of the Methylation Array analysis as a novel clinical test (under CLIA certification, CAP accreditation) offered to the CCR and outside clinical community. Establishing a comprehensive tumor molecular profile would assist ultimately in diagnostic precision and overall would impact the treatment decision and the outcome of the therapy. Methylation array analysis based on Illumina platform has been introduced to become an important addition to existing molecular diagnostic menu. Methylation array-based clinical testing became live for analysis of the Central Nervous System (CNS) tumor analysis in March 2019 with over 800 clinical cases been officially reported or studied as part of clinical research projects. This work is being performed in collaboration with the Neuro-Oncology Branch, NCI.