Administrative Core

行政核心

• 批准号: 10265432
• 负责人: R. Sean Morrison
• 金额: $ 50.63万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10265432
• 关键词: Academy; Address; Aging; Agreement; Award; Budgets; California; Caregivers; Caring; Clinical; Code; Collaborations; Communities; Complex; Contracts; Data; Data Security; Data Set; Data Sources; Dementia; Disease; Drug Prescriptions; Elderly; Ensure; Event; Family; Feedback; Fostering; Funding; Geriatrics; Gerontology; Goals; Health; Health Policy; Health system; Healthcare; Home; Hour; Infrastructure; Institution; Knowledge; Leadership; Learning; Manuals; Medical; Medicine; Mentors; Methodology; Modeling; Monitor; Outcome; Palliative Care; Patients; Personal Satisfaction; Persons; Policies; Population; Population Research; Preparation; Public Policy; Publications; Quality of life; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Priority; Research Project Grants; Research Support; Research Training; Resource Sharing; Resources; Retirement; Role; San Francisco; Scientist; Social Environment; Time; Training Activity; Translating; Translations; United States National Institutes of Health; Universities; Vision; Work; base; career development; clinical practice; community based care; cost efficient; data dictionary; data management; data resource; epidemiologic data; evidence base; experience; health care quality; health data; hospice environment; human subject; improved; innovation; medical schools; next generation; patient population; population based; programs; remediation; social; trend

RCA PROJECT SUMMARY The overarching goal of our P01, Deploying High Value Longitudinal Population-Based data in Dementia Research (DEVELOP AD RESEARCH), is to create an integrated program of research that considers the wider medical, health system, and social contexts of dementia that are important to patients and families and that have been inadequately considered in prior research. Our specific focus is on research questions that demand the use of population-based data resources and cannot be addressed by more mechanistically focused studies in a timely or cost-efficient manner. The P01 supports research that: a) examines the complex interaction of dementia and other serious illness; b) identifies the impact of clinical and social disruptive events on disease trajectory and outcomes; c) explores medication prescribing in the context of dementia; and d) examines how models of community-based care (hospice and home-based medical care) meet the needs of people with dementia and their families over the duration of illness. Leveraging our track record conducting groundbreaking research employing the rich, comprehensive, and longitudinal data of the HRS and NHATS, we will create the knowledge needed to enhance quality of life for persons with dementia and their caregivers. RCA will provide coordination and oversight of the P01 as well as the vision and leadership needed to advance and to translate our research findings into improvements in care. The specific aims of RCA are: · SA 1: To support scientific innovation for older adults with dementia by ensuring regular, ongoing coordinated scientific interaction, planning, learning and feedback between all cores and projects, and effective use of shared resources with optimal efficiency; · SA 2: To provide day-to-day management, including the preparation of administrative documents; management of fiscal matters of all projects and cores including oversight of all budgets, resources, and sub-contracts; and manage data use agreements, data security, human subjects review; · SA 3: To monitor research progress, implement necessary remediation, and ensure timely publication and dissemination of research findings; · SA 4: To leverage our national roles in the OAIC Network and National Palliative Care Research Center to disseminate our findings, resources, and programming codes and provide “office hours” and resources to early stage investigators across the nation engaged in population-based research programs in dementia. RCA advances population-based research in dementia and its translation into clinical practice through a comprehensive framework of coordinated activities. This framework provides infrastructure for research, nurtures and facilitates collaboration, promotes the use of cutting-edge methodologies, and disseminates results to the scientific and policy communities. RCA also incorporates an innovative focus on career development for early stage investigators and promotes the use of HRS and NHATS for dementia research.

RCA项目总结 我们P01的总体目标，在痴呆症中部署高价值的纵向基于人群的数据 研究（CIPAD RESEARCH），是创建一个综合的研究计划，考虑到 更广泛的医疗，卫生系统和痴呆症的社会背景对患者和家庭很重要， 在之前的研究中没有得到充分考虑。我们的具体重点是研究问题， 需要使用基于人口的数据资源，无法通过更机械的方式解决 以及时或具有成本效益的方式进行重点研究。P01支持以下研究：a）检查复合物 痴呆和其他严重疾病的相互作用; B）识别临床和社会破坏性事件的影响 关于疾病轨迹和结果; c）探讨痴呆症背景下的药物处方;以及d） 探讨如何以社区为基础的护理模式（临终关怀和家庭为基础的医疗护理）满足的需求， 痴呆症患者及其家人在患病期间的情况。利用我们的跟踪记录， 开创性的研究采用了HRS和NHATS的丰富，全面和纵向数据， 我们将创造提高痴呆症患者及其照顾者生活质量所需的知识。 RCA将提供P01的协调和监督，以及所需的愿景和领导， 推进并将我们的研究成果转化为护理的改善。区域合作协定的具体目标是： · SA 1：通过确保定期、持续地支持老年痴呆症患者的科学创新 协调所有核心和项目之间的科学互动、规划、学习和反馈，以及 以最佳效率有效利用共享资源; SA 2：提供日常管理，包括编写行政文件; 管理所有项目和核心的财务事项，包括监督所有预算、资源和 分包合同;并管理数据使用协议、数据安全、人类受试者审查; SA 3：监控研究进展，实施必要的补救措施，并确保及时发表， 传播研究成果; · SA 4：利用我们在OAIC网络和国家姑息治疗研究中心中的国家角色， 传播我们的研究结果、资源和编程代码，并提供“办公时间”和资源， 全国各地的早期研究人员从事以人口为基础的痴呆症研究项目。 RCA推进了痴呆症的人群研究，并通过一项 协调活动的综合框架。这一框架为研究提供了基础设施， 培养和促进合作，促进尖端方法的使用，并传播 科学界和政策界的成果。RCA还采用了创新的职业重点 为早期研究者开发，并促进HRS和NHATS在痴呆症研究中的使用。