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DC-HIL in cancer

DC-HIL in cancer
DC-HIL 在癌症中的应用
批准号：
10265335
负责人：
PONCIANO D CRUZ
金额：
$0.0万
依托单位：
VA NORTH TEXAS HEALTH CARE SYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
项目状态：
已结题
起止时间：
2018-01-01 至 2021-12-31
来源：
https://reporter.nih.gov/project-details/10265335
关键词：
AddressAdoptive TransferAnimalsAntigen-Presenting CellsAntitumor ResponseBindingBiological AssayBiological Response ModifiersBloodCD8-Positive T-LymphocytesCTLA4 geneCancer ModelCancer PatientCell physiologyCellsColonColon CarcinomaEnhancersGene DeletionGrowthHeparitin SulfateImmune TargetingImmune checkpoint inhibitorImmunologicsInflammatoryKineticsLeadLigandsMC38Malignant NeoplasmsMeasuresMediator of activation proteinMetastatic MelanomaMetastatic Neoplasm to the LungMinorityModalityModelingMonoclonal AntibodiesMorbidity - disease rateMusMyeloid-derived suppressor cellsNeoplasm MetastasisOutcomePD-1/PD-L1PDL1 pathwayPathway interactionsPatientsPolysaccharidesProliferatingProstateRegulationResistanceSILV geneSignal TransductionSolid NeoplasmSuppressor-Effector T-LymphocytesT-Cell ActivationT-LymphocyteTimeTreatment EfficacyTumor Immunityanti-PD-1anti-PD-L1 therapyanti-canceranticancer treatmentcancer immunotherapycancer therapycell transformationimmune checkpointimmune checkpoint blockersimmunogenicityimprovedinhibitor/antagonistlung Carcinomamelanomamonoclonal antibody LL2mortalitymouse modelnoveloptimal treatmentsprogrammed cell death ligand 1programmed cell death protein 1promoterreceptorsyndecan-4tumor

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英文摘要
Melanoma and other cancers continue to cause significant morbidity and mortality. Having discovered an immune regulator (DC-HIL) whose function can be manipulated to treat cancers, we will: (1) determine whether DC-HIL accounts for resistance to current cancer immunotherapy; (2) characterize the combination of mAb against immune targets that produces optimal treatment benefits; and (3) elucidate how blocking the DC-HIL ligand (syndecan-4) on T cells leads to better outcomes for cancer treatments. Our results will improve current management of metastatic melanoma and other cancers.
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DC-HIL in cancer
Dermatology Research Training Program
  • 批准号：
    8883391
  • 项目类别：
  • 资助金额：
    $12.74万
  • 财政年份：
    2014
  • 负责人：
    PONCIANO D CRUZ
  • 依托单位：
    UT SOUTHWESTERN MEDICAL CENTER
Dermatology Research Training Program
  • 批准号：
    8665270
  • 项目类别：
  • 资助金额：
    $12.52万
  • 财政年份：
    2014
  • 负责人：
    PONCIANO D CRUZ
  • 依托单位：
    UT SOUTHWESTERN MEDICAL CENTER
DC-HIL in skin cancer.
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