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DC-HIL in cancer

DC-HIL in cancer
DC-HIL 在癌症中的应用
批准号：
10485609
负责人：
PONCIANO D CRUZ
金额：
$0.0万
依托单位：
VA NORTH TEXAS HEALTH CARE SYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
项目状态：
未结题
起止时间：
2018-01-01 至 2026-09-30
来源：
https://reporter.nih.gov/project-details/10485609
关键词：
AblationAngiogenesis PathwayAngiogenic FactorB-LymphocytesBindingBiological AssayBlood VesselsCTLA4 geneCarbohydratesCellsCre lox recombination systemEndothelial CellsEpitopesExtravasationFGF2 geneFibroblastsGenesGrowthHeparan Sulfate BiosynthesisHeparan Sulfate ProteoglycanHeparitin SulfateHistologyHumanImmuneImmune checkpoint inhibitorImmunityImmunoprecipitationImmunosuppressionImpairmentImplantInfusion proceduresLeucocytic infiltrateLigandsLinkLocationMalignant NeoplasmsMediatingMelanoma CellMetastatic MelanomaMetastatic Neoplasm to the LungModalityModelingMonoclonal AntibodiesMorbidity - disease rateMusMutationNeoplasm MetastasisOligosaccharidesOrangesOutcomePathogenesisPathway interactionsPatientsPatternPolysaccharidesPropertyProteoglycanResistanceSignal TransductionSkinSulfateT ChainT cell responseT-LymphocyteTamoxifenTestingTissuesTumor AngiogenesisTyrosine Kinase InhibitorVascular Endothelial Growth FactorsXenograft procedureangiogenesisanti-PD-L1anti-PD-L1 therapychemokineeffective therapyimmune checkpointimprovedin vivomelanomamilitary veteranmortalitymouse modelnovelprogrammed cell death ligand 1receptorsubcutaneoussyndecan-4targeted treatmenttumortumor growthtumor progression

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PROJECT SUMMARY Melanoma is a significant cause of morbidity and mortality in the U.S. and among military veterans. Having discovered an immune-vascular regulating pathway (DC- HIL/SD4) whose function can be manipulated to treat cancers, we will: (1) dissect its effects on immunity and vascularity in melanoma; (2) develop treatment targeted at a key carbohydrate component of the pathway; and (3) characterize changes in this component during melanoma growth and metastasis. Our results will improve current management of metastatic melanoma and potentially other cancers.
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DC-HIL in cancer
Dermatology Research Training Program
  • 批准号：
    8883391
  • 项目类别：
  • 资助金额：
    $12.74万
  • 财政年份：
    2014
  • 负责人：
    PONCIANO D CRUZ
  • 依托单位：
    UT SOUTHWESTERN MEDICAL CENTER
Dermatology Research Training Program
  • 批准号：
    8665270
  • 项目类别：
  • 资助金额：
    $12.52万
  • 财政年份：
    2014
  • 负责人：
    PONCIANO D CRUZ
  • 依托单位：
    UT SOUTHWESTERN MEDICAL CENTER
DC-HIL in skin cancer.