DC-HIL in cancer

DC-HIL 在癌症中的应用

• 批准号: 10485609
• 负责人: PONCIANO D CRUZ
• 金额: --
• 依托单位: VA NORTH TEXAS HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2026-09-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10485609
• 关键词: Ablation; Angiogenesis Pathway; Angiogenic Factor; B-Lymphocytes; Binding; Biological Assay; Blood Vessels; CTLA4 gene; Carbohydrates; Cells; Cre lox recombination system; Endothelial Cells; Epitopes; Extravasation; FGF2 gene; Fibroblasts; Genes; Growth; Heparan Sulfate Biosynthesis; Heparan Sulfate Proteoglycan; Heparitin Sulfate; Histology; Human; Immune; Immune checkpoint inhibitor; Immunity; Immunoprecipitation; Immunosuppression; Impairment; Implant; Infusion procedures; Leucocytic infiltrate; Ligands; Link; Location; Malignant Neoplasms; Mediating; Melanoma Cell; Metastatic Melanoma; Metastatic Neoplasm to the Lung; Modality; Modeling; Monoclonal Antibodies; Morbidity - disease rate; Mus; Mutation; Neoplasm Metastasis; Oligosaccharides; Oranges; Outcome; Pathogenesis; Pathway interactions; Patients; Pattern; Polysaccharides; Property; Proteoglycan; Resistance; Signal Transduction; Skin; Sulfate; T Chain; T cell response; T-Lymphocyte; Tamoxifen; Testing; Tissues; Tumor Angiogenesis; Tyrosine Kinase Inhibitor; Vascular Endothelial Growth Factors; Xenograft procedure; angiogenesis; anti-PD-L1; anti-PD-L1 therapy; chemokine; effective therapy; immune checkpoint; improved; in vivo; melanoma; military veteran; mortality; mouse model; novel; programmed cell death ligand 1; receptor; subcutaneous; syndecan-4; targeted treatment; tumor; tumor growth; tumor progression

PROJECT SUMMARY Melanoma is a significant cause of morbidity and mortality in the U.S. and among military veterans. Having discovered an immune-vascular regulating pathway (DC- HIL/SD4) whose function can be manipulated to treat cancers, we will: (1) dissect its effects on immunity and vascularity in melanoma; (2) develop treatment targeted at a key carbohydrate component of the pathway; and (3) characterize changes in this component during melanoma growth and metastasis. Our results will improve current management of metastatic melanoma and potentially other cancers.

项目摘要 黑色素瘤在美国是发病率和死亡率的重要原因， 退伍军人在发现了免疫血管调节途径（DC- HIL/SD 4）的功能可以被操纵来治疗癌症，我们将：（1）解剖其 影响免疫和血管的黑色素瘤;（2）开发治疗针对 途径的关键碳水化合物组分;和（3）表征这种变化 在黑色素瘤生长和转移过程中的成分。我们的结果将改善目前的 转移性黑色素瘤和潜在的其他癌症的管理。