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DC-HIL in skin cancer.

DC-HIL in skin cancer.
DC-HIL 在皮肤癌中的应用。
批准号：
8142520
负责人：
PONCIANO D CRUZ
金额：
$0.0万
依托单位：
VA NORTH TEXAS HEALTH CARE SYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-10-01 至 2015-09-30
来源：
https://reporter.nih.gov/project-details/8142520
关键词：
AddressAntigen-Presenting CellsBindingCellsCessation of lifeDistantExhibitsFosteringGeneticGrowthHumanImmune systemImmunityImmunobiologyIncidenceIntraperitoneal InjectionsKnockout MiceKnowledgeLearningLifeMalignant NeoplasmsMediatingMedical centerMelanoma CellMembrane ProteinsMetastatic MelanomaModelingMolecularMorbidity - disease rateMusOperative Surgical ProceduresOrganPathway interactionsPatientsProtocols documentationSkin CancerT-Cell ActivationT-LymphocyteTestingTherapeuticThickUnited StatesVeteransfightingkillingsknock-downlymph nodesmelanomamortalitynovelpreventresponsesyndecan-4trendtumor

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中文摘要
翻译
描述(由申请人提供)： 皮肤癌是美国最常见的癌症，而且人数还在增加。皮肤癌的死亡主要是由于黑色素瘤，黑色素瘤的数量也在增加。通过手术切除的较薄的黑色素瘤(厚度小于1毫米)与正常生活相关，但较厚的黑色素瘤(超过4毫米)被认为已经扩散到淋巴结或远处器官，无法通过现有的治疗方法治愈。在发现黑色素瘤含有阻止免疫系统杀死肿瘤的分子后，我们将研究如何中和这些分子，以便免疫系统能够更好地对抗这种致命的癌症。
英文摘要
DESCRIPTION (provided by applicant): Skin cancer is the most common cancer in the United States and its numbers are increasing. Deaths from skin cancer are due mostly to melanoma, whose numbers are also increasing. Thin melanomas (less than 1 mm in thickness) removed by surgery are associated with normal life, but thicker melanomas (more than 4 mm) are considered to have already spread to lymph nodes or distant organs, and cannot be cured by available treatments. Having discovered melanoma to contain molecules preventing the immune system from killing the tumor, we will study how to counteract these molecules so the immune system can better fight this deadly cancer.
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DC-HIL in cancer
DC-HIL in cancer
Dermatology Research Training Program
  • 批准号：
    8883391
  • 项目类别：
  • 资助金额：
    $12.74万
  • 财政年份：
    2014
  • 负责人：
    PONCIANO D CRUZ
  • 依托单位：
    UT SOUTHWESTERN MEDICAL CENTER
Dermatology Research Training Program
  • 批准号：
    8665270
  • 项目类别：
  • 资助金额：
    $12.52万
  • 财政年份：
    2014
  • 负责人：
    PONCIANO D CRUZ
  • 依托单位：
    UT SOUTHWESTERN MEDICAL CENTER
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