Pilot

项目摘要 试点项目计划是NAMDC的重要组成部分，支持1-2个试点项目 每年。NAMDC试点项目侧重于生物标志物，诊断，自然史和治疗， 线粒体疾病因此，项目必须是人类受试者研究，包括：患者，人类 细胞、组织或体液样品。试点赠款往往是初级调查员的第一步， 其中，赠款申请通常是第一次正式申请。Pilot Core提供多个 初级调查员的辅导步骤，包括反馈：关于初步建议（包括 无资金的建议，以提高应用程序的质量），沿着充分赠款的发展 在项目实施过程中，？指导由NAMDC PI、统计PI， 试点核心PI、当地研究中心PI、NAMDC临床联络员和所需的其他资源。的 NAMDC试点/新项目委员会负责审查试点/新项目 提案试点项目的申请人必须是NAMDC成员。NAMDC试点项目 委员会建议作出最符合联合国需要和优先事项的供资决定， 并鼓励其发展。资金的选择是基于以下信息： 书面同行评审和NAMDC PI在年度面对面会议上口头介绍后， 见面会。根据试点方案委员会的建议，NAMDC 执行委员会最终决定资助哪些试点/新项目 在RDCRN的输入和NIH官员的批准下。多中心研究将 优先于单一研究项目。申请人申请资助的项目发生 在国家卫生研究院资助的NAMDC年度周期的12个月窗口期间。这意味着申请人 申请将于9月1日至8月31日期间进行的以下项目 年受助人应提交一份简短的季度报告， 在年度面对面会议上，并在会议结束后两个月内提交最终报告。 格兰特.

Project Summary Abstract The Pilot Project Program is an important component of NAMDC, and supports 1-2 pilot projects annually. NAMDC pilot projects focus on biomarkers, diagnosis, natural history, and treatment of mitochondrial diseases. Thus, projects must be human subject studies, including: patients, human cells, tissues, or body fluid samples. Pilot grants are often a first step for junior investigators, where the grant application is often a first formal application. The Pilot Core provides multiple mentoring steps for junior investigators including feedback: on initial proposals (including unfunded proposals to improve the quality of the application), along the full grant development process, and during project implementation. Mentoring is done by the NAMDC PI, Statistical PI, Pilot Core PI, local site PI, NAMDC Clinical Liaison, and additional resources as needed. The NAMDC Pilot/New Program Committee is responsible for reviewing the pilot/new project proposals. Applicants for Pilot Projects must be NAMDC members. The NAMDC Pilot Project Committee recommends funding decisions that best meets the needs and priorities of the consortium and encourages its growth. Selection for funding is based upon information from written peer review and from the NAMDC PIs following oral presentation at the annual Face-to- Face meeting. Following the recommendation by the Pilot Program Committee, the NAMDC Executive Committee makes the ultimate decision as to what pilot/new projects will be funded with input from the RDCRN and approval from the NIH officers. Multicenter studies will be prioritized over a single-site study projects. Applicants apply for funding for projects that occur during the 12-month window of NAMDC yearly cycle of NIH funding. This means that applicants apply for projects that will be carried out between September 1st through August 31 of the following year. Grantees are expected to submit a brief quarterly report, a preliminary report presentation at the annual Face-to-Face meeting, and a final report within two months of the conclusion of the grant.