A Handheld Microchip for GC analysis of breath to screen for COVID-19

用于呼吸气相色谱分析以筛查 COVID-19 的手持式微芯片

基本信息

  • 批准号:
    10266377
  • 负责人:
  • 金额:
    $ 102.67万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-12-21 至 2024-01-31
  • 项目状态:
    已结题

项目摘要

Project Summary The COVID-19 pandemic has caused unprecedented societal suffering and economic disruption. In the United States, more than six million people have contracted COVID-19 and more than one hundred ninety thousand patients have died of this disease to date. Although current COVID-19 diagnostic testing technologies are critical for slowing the spread of the virus and preventing future outbreaks, they are not practical for field use. Current diagnostic tests are cumbersome to perform because they use aqueous solutions, require multiple steps, and hours-to-days to obtain results. Since the US began to reopen the economy in May, there has been a significant increase in the number of COVID-19 cases. Therefore, there is an urgent need to develop a diagnostic approach that is non-invasive, portable, and can rapidly provide test results. The overall goal of the project is to develop a mobile breath analysis technology for rapid screening for COVID-19 using a handheld breath collection tool and a portable GC with a photoionization detector (PID). The handheld tool will be a closed system for trapping select volatile organic compounds (VOCs) on a microfabricated chip. The captured VOCs will be eluted with ethanol and then analyzed using a commercially available, portable GC-PID instrument. Artificial intelligence (AI) and machine learning algorithms will be applied to recognize the VOC pattern that correlates with COVID-19 infection. The central innovation is the microfabricated chip that captures carbonyl compounds in exhaled breath and thus serves as a preconcentrator, which enables analysis of carbonyl VOCs by the portable GC-PID. The hypothesis is that the carbonyl metabolome in exhaled breath is directly related to the body’s reaction to the novel coronavirus infection, and changes in the carbonyl VOC composition in exhaled breath relative to healthy controls can be used to detect both symptomatic and asymptomatic COVID-19 patients. Three specific aims are proposed to fulfill the overall goal. Aim 1 is to build a disposable handheld breath analyzer tool for concentrating carbonyl VOCs. Aim 2 is to identify VOC patterns in the breath of COVID-19 patients by machine learning algorithms. Aim 3 is to integrate portable GC technology with the breath sampling tool for COVID-19 screening guided by an AI system. The University of Louisville is uniquely suited to rapidly transition the microchip technology to field use because of the PI and Co-PI’s experience in breath analysis and translational research, and the project team’s experience in virology, infectious diseases, biostatistics, and artificial intelligence as well as the state-of-the-art facilities that include a MicroNano Technology Center, Biosafety Level 3 Regional Biocontainment Lab, and an NIH-funded REACH program.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Xiao-An Fu其他文献

Xiao-An Fu的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Xiao-An Fu', 18)}}的其他基金

A Handheld Microchip for GC analysis of breath to screen for COVID-19
用于呼吸气相色谱分析以筛查 COVID-19 的手持式微芯片
  • 批准号:
    10320985
  • 财政年份:
    2020
  • 资助金额:
    $ 102.67万
  • 项目类别:
A microreactor chip platform for quantitative analysis of unsaturated aldehydes in exhaled breath
呼出气中不饱和醛定量分析的微反应器芯片平台
  • 批准号:
    9981690
  • 财政年份:
    2018
  • 资助金额:
    $ 102.67万
  • 项目类别:
A microreactor chip platform for quantitative analysis of unsaturated aldehydes in exhaled breath
呼出气中不饱和醛定量分析的微反应器芯片平台
  • 批准号:
    9768418
  • 财政年份:
    2018
  • 资助金额:
    $ 102.67万
  • 项目类别:

相似海外基金

Acute senescence: a novel host defence counteracting typhoidal Salmonella
急性衰老:对抗伤寒沙门氏菌的新型宿主防御
  • 批准号:
    MR/X02329X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 102.67万
  • 项目类别:
    Fellowship
Transcriptional assessment of haematopoietic differentiation to risk-stratify acute lymphoblastic leukaemia
造血分化的转录评估对急性淋巴细胞白血病的风险分层
  • 批准号:
    MR/Y009568/1
  • 财政年份:
    2024
  • 资助金额:
    $ 102.67万
  • 项目类别:
    Fellowship
Combining two unique AI platforms for the discovery of novel genetic therapeutic targets & preclinical validation of synthetic biomolecules to treat Acute myeloid leukaemia (AML).
结合两个独特的人工智能平台来发现新的基因治疗靶点
  • 批准号:
    10090332
  • 财政年份:
    2024
  • 资助金额:
    $ 102.67万
  • 项目类别:
    Collaborative R&D
Cellular Neuroinflammation in Acute Brain Injury
急性脑损伤中的细胞神经炎症
  • 批准号:
    MR/X021882/1
  • 财政年份:
    2024
  • 资助金额:
    $ 102.67万
  • 项目类别:
    Research Grant
STTR Phase I: Non-invasive focused ultrasound treatment to modulate the immune system for acute and chronic kidney rejection
STTR 第一期:非侵入性聚焦超声治疗调节免疫系统以治疗急性和慢性肾排斥
  • 批准号:
    2312694
  • 财政年份:
    2024
  • 资助金额:
    $ 102.67万
  • 项目类别:
    Standard Grant
Combining Mechanistic Modelling with Machine Learning for Diagnosis of Acute Respiratory Distress Syndrome
机械建模与机器学习相结合诊断急性呼吸窘迫综合征
  • 批准号:
    EP/Y003527/1
  • 财政年份:
    2024
  • 资助金额:
    $ 102.67万
  • 项目类别:
    Research Grant
FITEAML: Functional Interrogation of Transposable Elements in Acute Myeloid Leukaemia
FITEAML:急性髓系白血病转座元件的功能研究
  • 批准号:
    EP/Y030338/1
  • 财政年份:
    2024
  • 资助金额:
    $ 102.67万
  • 项目类别:
    Research Grant
KAT2A PROTACs targetting the differentiation of blasts and leukemic stem cells for the treatment of Acute Myeloid Leukaemia
KAT2A PROTAC 靶向原始细胞和白血病干细胞的分化,用于治疗急性髓系白血病
  • 批准号:
    MR/X029557/1
  • 财政年份:
    2024
  • 资助金额:
    $ 102.67万
  • 项目类别:
    Research Grant
ロボット支援肝切除術は真に低侵襲なのか?acute phaseに着目して
机器人辅助肝切除术真的是微创吗?
  • 批准号:
    24K19395
  • 财政年份:
    2024
  • 资助金额:
    $ 102.67万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Collaborative Research: Changes and Impact of Right Ventricle Viscoelasticity Under Acute Stress and Chronic Pulmonary Hypertension
合作研究:急性应激和慢性肺动脉高压下右心室粘弹性的变化和影响
  • 批准号:
    2244994
  • 财政年份:
    2023
  • 资助金额:
    $ 102.67万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了