High-Field Animal Magnetic Resonance Imaging System

高场动物磁共振成像系统

• 批准号: 6803785
• 负责人: RAO P GULLAPALLI
• 金额: $ 197.8万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6803785
• 关键词: biomedical equipment purchase; nuclear magnetic resonance spectroscopy

DESCRIPTION (provided by applicant): The University of Maryland, Baltimore currently has 18 NIH funded research projects that could greatly benefit from the availability of a shared high-field animal imaging magnetic resonance system. The projects cover a wide array of high impact, cutting edge biomedical research including topics such as, brain development and disease processes through diffusion tensor imaging, understanding brain metabolism involved in white matter disease, understanding progression of breast and prostate cancer and studying the efficacy of therapeutic agents, the pathogenic mechanisms of human herpesvirus, tumorigenesis, the progression of neurodegenerative events and studying the long and short term consequences of pharmacological treatment, the neuronal mechanisms of pain, cardiac dynamics, metabolic and development aspects of mental retardation, development of drug delivery agents for effective treatment of cancer, and many other such projects that are state-of-the-art and push the envelope of our scientific knowledge. The availability of a shared 7 Tesla animal MRI would allow investigators to probe into basic biological processes, understand the progression of disease, and follow the effects of novel pharmacological interventions through the use of multi-nuclear spectroscopy and imaging. The purchase of a 7.0 Tesla animal imaging system will be an important component to our existing shared resources on campus and will complement the high resolution NMR spectrometers that are used primarily for studying biological structures. This imaging resource will be located in specially designed space, in close proximity to the animal holding area and right next to two animal surgical suites. The Schools of Medicine, Pharmacy, and Dentistry, the Greenebaum Research Center, and the University of Maryland Biotechnology Institute join together in this shared instrument application. Institutional commitment for supporting the expenses and responsibilities for its operations will also be shared by the different schools and institutes of this campus. The number and quality of biomedical research projects performed at the University of Maryland Baltimore campus has reached a level that will guarantee a continued and pressing need to a high-field animal imaging system.

描述（由申请人提供）： 位于巴尔的摩的马里兰州大学目前有18个NIH资助的研究项目，这些项目可以从共享的高场动物成像磁共振系统中受益匪浅。这些项目涵盖了广泛的高影响力，尖端生物医学研究，包括通过扩散张量成像了解大脑发育和疾病过程，了解白色疾病涉及的大脑代谢，了解乳腺癌和前列腺癌的进展，研究治疗药物的疗效，人类疱疹病毒的致病机制，肿瘤发生，神经变性事件的进展和研究药理学治疗的长期和短期后果，疼痛的神经机制，心脏动力学，精神发育迟滞的代谢和发育方面，用于有效治疗癌症的药物递送剂的开发，以及其他许多先进的项目，这些项目推动了我们科学知识的发展。共享的7特斯拉动物MRI的可用性将使研究人员能够探索基本的生物学过程，了解疾病的进展，并通过使用多核光谱和成像来跟踪新型药物干预的效果。购买7.0特斯拉动物成像系统将是我们校园现有共享资源的重要组成部分，并将补充主要用于研究生物结构的高分辨率NMR光谱仪。该成像资源将位于专门设计的空间内，靠近动物饲养区，紧邻两个动物手术室。医学院、药学院和牙科学院、Greenebaum研究中心和马里兰州大学生物技术研究所共同参与了这一共享仪器应用。支持其运营费用和责任的机构承诺也将由该校园的不同学校和研究所分担。在马里兰州巴尔的摩校区进行的生物医学研究项目的数量和质量已经达到了一个水平，将保证持续和迫切需要一个高场动物成像系统。

项目成果

Olanzapine antipsychotic treatment of adolescent rats causes long term changes in glutamate and GABA levels in the nucleus accumbens.

• DOI: 10.1016/j.schres.2014.10.034
• 发表时间: 2015-02
• 期刊: SCHIZOPHRENIA RESEARCH
• 影响因子: 4.5
• 作者: Xu, Su;Gullapalli, Rao P.;Frost, Douglas O.
• 通讯作者: Frost, Douglas O.

Phrygian Cap Appearance of a Mouse Gallbladder on Magnetic Resonance Imaging.

磁共振成像中小鼠胆囊的弗里吉亚帽外观。

• DOI: 10.4172/2325-9590.1000110
• 发表时间: 2013
• 期刊: Journal of veterinary science & medical diagnosis
• 作者: Raufman,Jean-Pierre;Xu,Su;Cheng,Kunrong;Khurana,Sandeep;Vivian,Diana;Shi,Da;Gullapalli,Rao;Polli,James
• 通讯作者: Polli,James

Diffusion kurtosis as an in vivo imaging marker for reactive astrogliosis in traumatic brain injury.

• DOI: 10.1016/j.neuroimage.2011.07.050
• 发表时间: 2012-01-02
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Zhuo J;Xu S;Proctor JL;Mullins RJ;Simon JZ;Fiskum G;Gullapalli RP
• 通讯作者: Gullapalli RP